JP7676109B2 - 抗ｋｉｒ３ｄｌ２剤による処置 - Google Patents

抗ｋｉｒ３ｄｌ２剤による処置 Download PDF

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JP7676109B2
JP7676109B2 JP2019520882A JP2019520882A JP7676109B2 JP 7676109 B2 JP7676109 B2 JP 7676109B2 JP 2019520882 A JP2019520882 A JP 2019520882A JP 2019520882 A JP2019520882 A JP 2019520882A JP 7676109 B2 JP7676109 B2 JP 7676109B2
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kir3dl2
antibody
optionally
cells
binding
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JP2020500161A5 (enExample
JP2020500161A (ja
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カリーヌ・パトゥレル
エレーヌ・シカール
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Innate Pharma SA
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Innate Pharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019520882A 2016-10-21 2017-10-19 抗ｋｉｒ３ｄｌ２剤による処置 Active JP7676109B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662410880P 2016-10-21 2016-10-21
US62/410,880 2016-10-21
PCT/EP2017/076751 WO2018073363A1 (en) 2016-10-21 2017-10-19 Treatment with anti-kir3dl2 agents

Publications (3)

Publication Number Publication Date
JP2020500161A JP2020500161A (ja) 2020-01-09
JP2020500161A5 JP2020500161A5 (enExample) 2020-11-26
JP7676109B2 true JP7676109B2 (ja) 2025-05-14

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JP2019520882A Active JP7676109B2 (ja) 2016-10-21 2017-10-19 抗ｋｉｒ３ｄｌ２剤による処置

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US (3) US20190248895A1 (enExample)
EP (1) EP3529277A1 (enExample)
JP (1) JP7676109B2 (enExample)
KR (2) KR20230173745A (enExample)
CN (1) CN109863175A (enExample)
AU (1) AU2017345203B2 (enExample)
CA (1) CA3037851A1 (enExample)
WO (1) WO2018073363A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2682449C2 (ru) 2012-09-19 2019-03-19 Иннейт Фарма Связывающие kir3dl2 агенты
DK3896088T3 (da) 2013-02-20 2025-09-29 Innate Pharma Behandling af perifert t-cellelymfom
EP3116908B1 (en) 2014-03-14 2019-06-26 Innate Pharma Humanized kir3dl2 antibodies
BR112021014236A2 (pt) * 2019-01-22 2021-09-28 Innate Pharma Anticorpo, composição farmacêutica, kit e método para predizer ou avaliar a eficácia
US20250388702A1 (en) * 2019-10-04 2025-12-25 Dana-Farber Cancer Institute, Inc. Anti-kir3dl3 antibodies and uses thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2015136052A1 (en) 2014-03-14 2015-09-17 Innate Pharma Humanized antibodies with increased stability
JP2016513104A (ja) 2013-02-20 2016-05-12 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． 末梢ｔ細胞リンパ腫の処置における使用のためのｋｉｒ３ｄｌ２に特異的に結合する化合物

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Also Published As

Publication number Publication date
AU2017345203B2 (en) 2024-08-01
US11970535B2 (en) 2024-04-30
KR20190068602A (ko) 2019-06-18
US20190248895A1 (en) 2019-08-15
KR20230173745A (ko) 2023-12-27
WO2018073363A1 (en) 2018-04-26
CN109863175A (zh) 2019-06-07
JP2020500161A (ja) 2020-01-09
CA3037851A1 (en) 2018-04-26
EP3529277A1 (en) 2019-08-28
AU2017345203A1 (en) 2019-05-02
US20240391999A1 (en) 2024-11-28
US20210087270A1 (en) 2021-03-25

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