JP7674770B2 - ポリペプチド化合物の製造方法 - Google Patents

ポリペプチド化合物の製造方法 Download PDF

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JP7674770B2
JP7674770B2 JP2023574848A JP2023574848A JP7674770B2 JP 7674770 B2 JP7674770 B2 JP 7674770B2 JP 2023574848 A JP2023574848 A JP 2023574848A JP 2023574848 A JP2023574848 A JP 2023574848A JP 7674770 B2 JP7674770 B2 JP 7674770B2
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group
formula
compound
groups
substituents
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JPWO2023210692A5 (https=
JPWO2023210692A1 (https=
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尚 山本
倫弘 服部
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Chubu University
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Chubu University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023574848A 2022-04-27 2023-04-26 ポリペプチド化合物の製造方法 Active JP7674770B2 (ja)

Priority Applications (1)

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JP2024177370A JP2025004189A (ja) 2022-04-27 2024-10-09 ポリペプチド化合物の製造方法

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JP2022073475 2022-04-27
JP2022073475 2022-04-27
PCT/JP2023/016457 WO2023210692A1 (ja) 2022-04-27 2023-04-26 ポリペプチド化合物の製造方法

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JPWO2023210692A5 JPWO2023210692A5 (https=) 2024-04-08
JP7674770B2 true JP7674770B2 (ja) 2025-05-12

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JP2024177370A Pending JP2025004189A (ja) 2022-04-27 2024-10-09 ポリペプチド化合物の製造方法

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US (1) US20250296954A1 (https=)
EP (1) EP4516799A4 (https=)
JP (2) JP7674770B2 (https=)
WO (1) WO2023210692A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017518290A (ja) 2014-05-19 2017-07-06 トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． β−アレスチンエフェクターの合成
WO2021149814A1 (ja) 2020-01-22 2021-07-29 学校法人中部大学 アミド化合物の製造用触媒及び製造方法
WO2021262710A1 (en) 2020-06-22 2021-12-30 Stealth Biotherapeutics Corp. Prodrugs of mitochodria-targeting oligopeptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103100B2 (ja) * 1987-02-27 1995-11-08 日本臓器製薬株式会社 新規ジペプチド
JPH0713052B2 (ja) * 1987-02-27 1995-02-15 日本臓器製薬株式会社 ジペプチド
JPH01503626A (ja) * 1987-06-19 1989-12-07 フセソユズニ　カルディオロギチェスキ　ナウチニツェントル　アカデミイ　メディツィンスキフ　ナウク　エスエスエスエル ヘキサペプチド及び胃腸管のびらん性及び潰瘍性損傷を処理するために前記ペプチドから製造された医薬製剤
JP6744669B2 (ja) 2016-05-23 2020-08-19 学校法人中部大学 水酸基を配向基とするエステルからアミドへの変換触媒
CN110662736A (zh) 2017-04-25 2020-01-07 学校法人中部大学 酰胺化合物的制造方法
JPWO2018199146A1 (ja) 2017-04-25 2020-02-27 学校法人中部大学 オキシム・ヒドロキシアミンを基質とするエステルからアミドへの変換触媒
CN112020492B (zh) 2018-04-25 2023-05-05 学校法人中部大学 酰胺化合物的制造方法
JP7244134B2 (ja) 2019-10-30 2023-03-22 学校法人中部大学 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法
EP4053101A4 (en) 2019-10-30 2024-02-21 Chubu University Educational Foundation REACTANT FOR AMIDE REACTION AND METHOD FOR PRODUCING AN AMIDE COMPOUND USING THE SAME
JP7171115B1 (ja) 2021-03-09 2022-11-15 学校法人中部大学 シラン含有縮合環ジペプチド化合物及びその製造方法、並びにそれを用いたポリペプチド化合物の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017518290A (ja) 2014-05-19 2017-07-06 トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． β−アレスチンエフェクターの合成
WO2021149814A1 (ja) 2020-01-22 2021-07-29 学校法人中部大学 アミド化合物の製造用触媒及び製造方法
WO2021262710A1 (en) 2020-06-22 2021-12-30 Stealth Biotherapeutics Corp. Prodrugs of mitochodria-targeting oligopeptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROOS, E. C. et al., Palladium-Catalyzed Transprotection of Allyloxycarbonyl-Protected Amines: Efficient One-Pot Formatio, Journal of Organic Chemistry, 1995年, Vol. 60, P. 1733-1740

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EP4516799A1 (en) 2025-03-05
US20250296954A1 (en) 2025-09-25
WO2023210692A1 (ja) 2023-11-02
JP2025004189A (ja) 2025-01-14
JPWO2023210692A1 (https=) 2023-11-02
EP4516799A4 (en) 2025-10-01

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