JP7668273B2 - Ｂｃｌ６阻害剤としての［１，４］オキサゼピノ［２，３－ｃ］キノリノン誘導体 - Google Patents

Ｂｃｌ６阻害剤としての［１，４］オキサゼピノ［２，３－ｃ］キノリノン誘導体 Download PDF

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JP7668273B2
JP7668273B2 JP2022522065A JP2022522065A JP7668273B2 JP 7668273 B2 JP7668273 B2 JP 7668273B2 JP 2022522065 A JP2022522065 A JP 2022522065A JP 2022522065 A JP2022522065 A JP 2022522065A JP 7668273 B2 JP7668273 B2 JP 7668273B2
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difluoro
methyl
amino
cyclopropyl
oxazepino
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JP2022551950A (ja
JP2022551950A5 (OSRAM
Inventor
ベレニー，ベンジャミン・リチャード
ブレナン，アルフィー
チェン，カイ・ミン・ジャック
デイヴィス，オーウェン・アレクサンダー
ハーンデン，アリス・クレア
ヘルダー，スウェン
ハックヴェール，ローズマリー
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Institute of Cancer Research Royal Cancer Hospital
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Institute of Cancer Research Royal Cancer Hospital
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022522065A 2019-10-14 2020-10-14 Ｂｃｌ６阻害剤としての［１，４］オキサゼピノ［２，３－ｃ］キノリノン誘導体 Active JP7668273B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1914860.0 2019-10-14
GB201914860A GB201914860D0 (en) 2019-10-14 2019-10-14 Inhibitor compounds
PCT/GB2020/052588 WO2021074620A1 (en) 2019-10-14 2020-10-14 [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors

Publications (3)

Publication Number Publication Date
JP2022551950A JP2022551950A (ja) 2022-12-14
JP2022551950A5 JP2022551950A5 (OSRAM) 2023-10-19
JP7668273B2 true JP7668273B2 (ja) 2025-04-24

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JP2022522065A Active JP7668273B2 (ja) 2019-10-14 2020-10-14 Ｂｃｌ６阻害剤としての［１，４］オキサゼピノ［２，３－ｃ］キノリノン誘導体

Country Status (13)

Country Link
US (1) US12528826B2 (OSRAM)
EP (1) EP4045510B1 (OSRAM)
JP (1) JP7668273B2 (OSRAM)
KR (1) KR20220083761A (OSRAM)
CN (1) CN114650995A (OSRAM)
AU (1) AU2020365518B2 (OSRAM)
CA (1) CA3157716A1 (OSRAM)
ES (1) ES3047908T3 (OSRAM)
GB (1) GB201914860D0 (OSRAM)
IL (1) IL292182B1 (OSRAM)
MX (1) MX2022004419A (OSRAM)
WO (1) WO2021074620A1 (OSRAM)
ZA (1) ZA202203520B (OSRAM)

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GB201914860D0 (en) 2019-10-14 2019-11-27 Cancer Research Tech Ltd Inhibitor compounds
US12310975B2 (en) 2019-10-17 2025-05-27 Arvinas Operations, Inc. Modulators of BCL6 proteolysis and associated methods of use
CA3214806A1 (en) 2021-04-16 2022-10-20 Arvinas Operations, Inc. Modulators of bcl6 proteolysis and associated methods of use
CR20250001A (es) * 2022-06-06 2025-05-14 Treeline Biosciences Inc Degradadores bifuncionales de bcl6 de quinolona tricíclica
AU2023292893A1 (en) 2022-06-13 2025-01-02 Treeline Biosciences, Inc. Quinolone bcl6 bifunctional degraders
JP2025525324A (ja) 2022-06-13 2025-08-05 ツリーライン バイオサイエンシズ インコーポレイテッド １，８－ナフチリジン－２－オンヘテロ二官能性ｂｃｌ６分解剤
WO2024228505A1 (ko) * 2023-05-03 2024-11-07 인제대학교 산학협력단 Btk 분해제 및 bcl-6 분해제를 포함하는 암의 예방 또는 치료용 약학적 조성물
AU2024331309A1 (en) * 2023-09-01 2026-03-19 Treeline Biosciences, Inc. Tricyclic quinolone bcl6 bifunctional degraders

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WO2018215798A1 (en) 2017-05-26 2018-11-29 Cancer Research Technology Limited 2-quinolone derived inhibitors of bcl6

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Also Published As

Publication number Publication date
EP4045510B1 (en) 2025-07-30
WO2021074620A1 (en) 2021-04-22
CN114650995A (zh) 2022-06-21
MX2022004419A (es) 2022-08-08
IL292182A (en) 2022-06-01
CA3157716A1 (en) 2021-04-22
AU2020365518A1 (en) 2022-04-14
GB201914860D0 (en) 2019-11-27
JP2022551950A (ja) 2022-12-14
EP4045510A1 (en) 2022-08-24
WO2021074620A9 (en) 2021-06-17
EP4045510C0 (en) 2025-07-30
ES3047908T3 (en) 2025-12-05
AU2020365518B2 (en) 2026-04-23
ZA202203520B (en) 2025-09-25
US20240217987A1 (en) 2024-07-04
IL292182B1 (en) 2026-02-01
KR20220083761A (ko) 2022-06-20
US12528826B2 (en) 2026-01-20

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