JP2022551950A5 - - Google Patents
Info
- Publication number
- JP2022551950A5 JP2022551950A5 JP2022522065A JP2022522065A JP2022551950A5 JP 2022551950 A5 JP2022551950 A5 JP 2022551950A5 JP 2022522065 A JP2022522065 A JP 2022522065A JP 2022522065 A JP2022522065 A JP 2022522065A JP 2022551950 A5 JP2022551950 A5 JP 2022551950A5
- Authority
- JP
- Japan
- Prior art keywords
- difluoro
- methyl
- amino
- cyclopropyl
- oxazepino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1914860.0 | 2019-10-14 | ||
| GB201914860A GB201914860D0 (en) | 2019-10-14 | 2019-10-14 | Inhibitor compounds |
| PCT/GB2020/052588 WO2021074620A1 (en) | 2019-10-14 | 2020-10-14 | [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022551950A JP2022551950A (ja) | 2022-12-14 |
| JP2022551950A5 true JP2022551950A5 (OSRAM) | 2023-10-19 |
| JP7668273B2 JP7668273B2 (ja) | 2025-04-24 |
Family
ID=68619494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022522065A Active JP7668273B2 (ja) | 2019-10-14 | 2020-10-14 | Ｂｃｌ６阻害剤としての［１，４］オキサゼピノ［２，３－ｃ］キノリノン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12528826B2 (OSRAM) |
| EP (1) | EP4045510B1 (OSRAM) |
| JP (1) | JP7668273B2 (OSRAM) |
| KR (1) | KR20220083761A (OSRAM) |
| CN (1) | CN114650995A (OSRAM) |
| AU (1) | AU2020365518B2 (OSRAM) |
| CA (1) | CA3157716A1 (OSRAM) |
| ES (1) | ES3047908T3 (OSRAM) |
| GB (1) | GB201914860D0 (OSRAM) |
| IL (1) | IL292182B1 (OSRAM) |
| MX (1) | MX2022004419A (OSRAM) |
| WO (1) | WO2021074620A1 (OSRAM) |
| ZA (1) | ZA202203520B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019253510B2 (en) | 2018-04-13 | 2023-08-10 | Cancer Research Technology Limited | BCL6 inhibitors |
| GB201914860D0 (en) | 2019-10-14 | 2019-11-27 | Cancer Research Tech Ltd | Inhibitor compounds |
| US12310975B2 (en) | 2019-10-17 | 2025-05-27 | Arvinas Operations, Inc. | Modulators of BCL6 proteolysis and associated methods of use |
| CA3214806A1 (en) | 2021-04-16 | 2022-10-20 | Arvinas Operations, Inc. | Modulators of bcl6 proteolysis and associated methods of use |
| CR20250001A (es) * | 2022-06-06 | 2025-05-14 | Treeline Biosciences Inc | Degradadores bifuncionales de bcl6 de quinolona tricíclica |
| AU2023292893A1 (en) | 2022-06-13 | 2025-01-02 | Treeline Biosciences, Inc. | Quinolone bcl6 bifunctional degraders |
| JP2025525324A (ja) | 2022-06-13 | 2025-08-05 | ツリーライン バイオサイエンシズ インコーポレイテッド | １，８－ナフチリジン－２－オンヘテロ二官能性ｂｃｌ６分解剤 |
| WO2024228505A1 (ko) * | 2023-05-03 | 2024-11-07 | 인제대학교 산학협력단 | Btk 분해제 및 bcl-6 분해제를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| AU2024331309A1 (en) * | 2023-09-01 | 2026-03-19 | Treeline Biosciences, Inc. | Tricyclic quinolone bcl6 bifunctional degraders |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0259572A (ja) | 1988-08-23 | 1990-02-28 | Mitsubishi Kasei Corp | ベンズイミダゾロン誘導体又はその塩類 |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| ES2169355T3 (es) | 1996-03-05 | 2002-07-01 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina. |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| AU760250B2 (en) | 1998-12-04 | 2003-05-08 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BRPI0017548B8 (pt) | 1999-02-10 | 2023-05-02 | Astrazeneca Ab | Composto |
| CZ2002233A3 (cs) | 1999-07-21 | 2002-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazolonové deriváty, způsob jejich výroby a farmaceutický prostředek |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| WO2001094311A1 (en) | 2000-06-08 | 2001-12-13 | Mitsubishi Pharma Corporation | Cytoprotectors |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| HUP0301742A3 (en) | 2000-07-07 | 2005-08-29 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use |
| UY27304A1 (es) | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
| AU2003231231A1 (en) | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| US20050256157A1 (en) | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
| CA2656507C (en) | 2006-07-17 | 2012-03-20 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| WO2008066887A2 (en) | 2006-11-30 | 2008-06-05 | Albert Einstein College Of Medicine Of Yeshiva University | Small molecule inhibitors of bcl6 |
| US8686008B2 (en) | 2007-08-16 | 2014-04-01 | The University Of Mississippi | Highly selective sigma receptor ligands |
| WO2009063240A1 (en) | 2007-11-16 | 2009-05-22 | Arrow Therapeutics Limited | 2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase |
| US8071766B2 (en) | 2008-02-01 | 2011-12-06 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
| EP2364983B1 (en) | 2008-11-11 | 2013-10-23 | Jeil Pharmaceutical Co., Ltd. | Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same |
| PL2389372T3 (pl) | 2009-01-23 | 2016-02-29 | Rigel Pharmaceuticals Inc | Kompozycje i sposoby hamowania szlaku JAK |
| EA201290642A1 (ru) | 2010-01-13 | 2013-05-30 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Соединения и способы |
| ES2698847T3 (es) | 2011-07-07 | 2019-02-06 | Merck Patent Gmbh | Azaheterociclos sustituidos para el tratamiento del cáncer |
| CA2877146C (en) | 2012-06-18 | 2020-10-20 | Dart Neuroscience (Cayman) Ltd | Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds |
| EP2964642B1 (en) | 2013-03-05 | 2017-11-15 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
| US9943506B2 (en) | 2013-06-17 | 2018-04-17 | Cornell University | BCL6 inhibitors as anticancer agents |
| CN105017159B (zh) | 2014-04-28 | 2019-05-17 | 四川大学 | 5-氟-2,4-二取代氨基嘧啶衍生物及其制备方法和用途 |
| ES2914099T3 (es) | 2014-08-25 | 2022-06-07 | Salk Inst For Biological Studi | Inhibidores novedosos de ULK1 y métodos de uso de los mismos |
| WO2016033416A1 (en) | 2014-08-29 | 2016-03-03 | Board Of Regents, University Of Texas System | Bromodomain inhibitors for treating disease |
| AU2015357498B2 (en) | 2014-12-06 | 2019-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2017007658A1 (en) | 2015-07-07 | 2017-01-12 | Rigel Pharmaceuticals, Inc. | A combination for immune mediated cancer treatment |
| JP6999688B2 (ja) | 2016-12-13 | 2022-02-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｃｌ６阻害剤としての新規の６－アミノキノリノン化合物および誘導体 |
| AU2018274723B2 (en) | 2017-05-26 | 2024-01-18 | Cancer Research Technology Limited | Benzimidazolone derived inhibitors of BCL6 |
| US11161839B2 (en) | 2017-05-26 | 2021-11-02 | The Institute Of Cancer Research: Royal Cancer Hospital | 2-quinolone derived inhibitors of BCL6 |
| GB201819136D0 (en) | 2018-11-23 | 2019-01-09 | Cancer Research Tech Ltd | Inhibitor compounds |
| AU2019253510B2 (en) * | 2018-04-13 | 2023-08-10 | Cancer Research Technology Limited | BCL6 inhibitors |
| GB201914860D0 (en) | 2019-10-14 | 2019-11-27 | Cancer Research Tech Ltd | Inhibitor compounds |
-
2019
- 2019-10-14 GB GB201914860A patent/GB201914860D0/en not_active Ceased
-
2020
- 2020-10-13 IL IL292182A patent/IL292182B1/en unknown
- 2020-10-14 US US17/768,174 patent/US12528826B2/en active Active
- 2020-10-14 EP EP20793780.6A patent/EP4045510B1/en active Active
- 2020-10-14 ES ES20793780T patent/ES3047908T3/es active Active
- 2020-10-14 MX MX2022004419A patent/MX2022004419A/es unknown
- 2020-10-14 AU AU2020365518A patent/AU2020365518B2/en active Active
- 2020-10-14 CA CA3157716A patent/CA3157716A1/en active Pending
- 2020-10-14 KR KR1020227016037A patent/KR20220083761A/ko active Pending
- 2020-10-14 CN CN202080072281.5A patent/CN114650995A/zh active Pending
- 2020-10-14 WO PCT/GB2020/052588 patent/WO2021074620A1/en not_active Ceased
- 2020-10-14 JP JP2022522065A patent/JP7668273B2/ja active Active
-
2022
- 2022-03-25 ZA ZA2022/03520A patent/ZA202203520B/en unknown
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