AU2020365518B2 - [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors - Google Patents

[1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors

Info

Publication number
AU2020365518B2
AU2020365518B2 AU2020365518A AU2020365518A AU2020365518B2 AU 2020365518 B2 AU2020365518 B2 AU 2020365518B2 AU 2020365518 A AU2020365518 A AU 2020365518A AU 2020365518 A AU2020365518 A AU 2020365518A AU 2020365518 B2 AU2020365518 B2 AU 2020365518B2
Authority
AU
Australia
Prior art keywords
difluoro
methyl
amino
oxazepino
quinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020365518A
Other languages
English (en)
Other versions
AU2020365518A1 (en
Inventor
Benjamin Richard BELLENIE
Alfie BRENNAN
Kwai Ming Jack CHEUNG
Owen Alexander DAVIS
Alice Claire HARNDEN
Swen Hoelder
Rosemary HUCKVALE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
Original Assignee
Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Cancer Research Royal Cancer Hospital, Cancer Research Technology Ltd filed Critical Institute of Cancer Research Royal Cancer Hospital
Publication of AU2020365518A1 publication Critical patent/AU2020365518A1/en
Application granted granted Critical
Publication of AU2020365518B2 publication Critical patent/AU2020365518B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2020365518A 2019-10-14 2020-10-14 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors Active AU2020365518B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1914860.0 2019-10-14
GB201914860A GB201914860D0 (en) 2019-10-14 2019-10-14 Inhibitor compounds
PCT/GB2020/052588 WO2021074620A1 (en) 2019-10-14 2020-10-14 [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors

Publications (2)

Publication Number Publication Date
AU2020365518A1 AU2020365518A1 (en) 2022-04-14
AU2020365518B2 true AU2020365518B2 (en) 2026-04-23

Family

ID=68619494

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020365518A Active AU2020365518B2 (en) 2019-10-14 2020-10-14 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors

Country Status (13)

Country Link
US (1) US12528826B2 (OSRAM)
EP (1) EP4045510B1 (OSRAM)
JP (1) JP7668273B2 (OSRAM)
KR (1) KR20220083761A (OSRAM)
CN (1) CN114650995A (OSRAM)
AU (1) AU2020365518B2 (OSRAM)
CA (1) CA3157716A1 (OSRAM)
ES (1) ES3047908T3 (OSRAM)
GB (1) GB201914860D0 (OSRAM)
IL (1) IL292182B1 (OSRAM)
MX (1) MX2022004419A (OSRAM)
WO (1) WO2021074620A1 (OSRAM)
ZA (1) ZA202203520B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019253510B2 (en) 2018-04-13 2023-08-10 Cancer Research Technology Limited BCL6 inhibitors
GB201914860D0 (en) 2019-10-14 2019-11-27 Cancer Research Tech Ltd Inhibitor compounds
US12310975B2 (en) 2019-10-17 2025-05-27 Arvinas Operations, Inc. Modulators of BCL6 proteolysis and associated methods of use
CA3214806A1 (en) 2021-04-16 2022-10-20 Arvinas Operations, Inc. Modulators of bcl6 proteolysis and associated methods of use
CR20250001A (es) * 2022-06-06 2025-05-14 Treeline Biosciences Inc Degradadores bifuncionales de bcl6 de quinolona tricíclica
AU2023292893A1 (en) 2022-06-13 2025-01-02 Treeline Biosciences, Inc. Quinolone bcl6 bifunctional degraders
JP2025525324A (ja) 2022-06-13 2025-08-05 ツリーライン バイオサイエンシズ インコーポレイテッド １，８－ナフチリジン－２－オンヘテロ二官能性ｂｃｌ６分解剤
WO2024228505A1 (ko) * 2023-05-03 2024-11-07 인제대학교 산학협력단 Btk 분해제 및 bcl-6 분해제를 포함하는 암의 예방 또는 치료용 약학적 조성물
AU2024331309A1 (en) * 2023-09-01 2026-03-19 Treeline Biosciences, Inc. Tricyclic quinolone bcl6 bifunctional degraders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215798A1 (en) * 2017-05-26 2018-11-29 Cancer Research Technology Limited 2-quinolone derived inhibitors of bcl6
WO2019197842A1 (en) * 2018-04-13 2019-10-17 Cancer Research Technology Limited Bcl6 inhibitors

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0259572A (ja) 1988-08-23 1990-02-28 Mitsubishi Kasei Corp ベンズイミダゾロン誘導体又はその塩類
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
WO1997030035A1 (en) 1996-02-13 1997-08-21 Zeneca Limited Quinazoline derivatives as vegf inhibitors
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
AU760250B2 (en) 1998-12-04 2003-05-08 Neurosearch A/S New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BRPI0017548B8 (pt) 1999-02-10 2023-05-02 Astrazeneca Ab Composto
CZ2002233A3 (cs) 1999-07-21 2002-04-17 Fujisawa Pharmaceutical Co., Ltd. Benzimidazolonové deriváty, způsob jejich výroby a farmaceutický prostředek
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
WO2001094311A1 (en) 2000-06-08 2001-12-13 Mitsubishi Pharma Corporation Cytoprotectors
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
HUP0301742A3 (en) 2000-07-07 2005-08-29 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use
UY27304A1 (es) 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
AU2003231231A1 (en) 2002-05-06 2003-11-11 Bayer Pharmaceuticals Corporation Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
US20050256157A1 (en) 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
CA2656507C (en) 2006-07-17 2012-03-20 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
WO2008066887A2 (en) 2006-11-30 2008-06-05 Albert Einstein College Of Medicine Of Yeshiva University Small molecule inhibitors of bcl6
US8686008B2 (en) 2007-08-16 2014-04-01 The University Of Mississippi Highly selective sigma receptor ligands
WO2009063240A1 (en) 2007-11-16 2009-05-22 Arrow Therapeutics Limited 2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase
US8071766B2 (en) 2008-02-01 2011-12-06 Takeda Pharmaceutical Company Limited HSP90 inhibitors
EP2364983B1 (en) 2008-11-11 2013-10-23 Jeil Pharmaceutical Co., Ltd. Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
PL2389372T3 (pl) 2009-01-23 2016-02-29 Rigel Pharmaceuticals Inc Kompozycje i sposoby hamowania szlaku JAK
EA201290642A1 (ru) 2010-01-13 2013-05-30 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Соединения и способы
ES2698847T3 (es) 2011-07-07 2019-02-06 Merck Patent Gmbh Azaheterociclos sustituidos para el tratamiento del cáncer
CA2877146C (en) 2012-06-18 2020-10-20 Dart Neuroscience (Cayman) Ltd Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
EP2964642B1 (en) 2013-03-05 2017-11-15 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase
US9943506B2 (en) 2013-06-17 2018-04-17 Cornell University BCL6 inhibitors as anticancer agents
CN105017159B (zh) 2014-04-28 2019-05-17 四川大学 5-氟-2,4-二取代氨基嘧啶衍生物及其制备方法和用途
ES2914099T3 (es) 2014-08-25 2022-06-07 Salk Inst For Biological Studi Inhibidores novedosos de ULK1 y métodos de uso de los mismos
WO2016033416A1 (en) 2014-08-29 2016-03-03 Board Of Regents, University Of Texas System Bromodomain inhibitors for treating disease
AU2015357498B2 (en) 2014-12-06 2019-09-12 Intra-Cellular Therapies, Inc. Organic compounds
WO2017007658A1 (en) 2015-07-07 2017-01-12 Rigel Pharmaceuticals, Inc. A combination for immune mediated cancer treatment
JP6999688B2 (ja) 2016-12-13 2022-02-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｃｌ６阻害剤としての新規の６－アミノキノリノン化合物および誘導体
AU2018274723B2 (en) 2017-05-26 2024-01-18 Cancer Research Technology Limited Benzimidazolone derived inhibitors of BCL6
GB201819136D0 (en) 2018-11-23 2019-01-09 Cancer Research Tech Ltd Inhibitor compounds
GB201914860D0 (en) 2019-10-14 2019-11-27 Cancer Research Tech Ltd Inhibitor compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215798A1 (en) * 2017-05-26 2018-11-29 Cancer Research Technology Limited 2-quinolone derived inhibitors of bcl6
WO2019197842A1 (en) * 2018-04-13 2019-10-17 Cancer Research Technology Limited Bcl6 inhibitors

Also Published As

Publication number Publication date
EP4045510B1 (en) 2025-07-30
WO2021074620A1 (en) 2021-04-22
JP7668273B2 (ja) 2025-04-24
CN114650995A (zh) 2022-06-21
MX2022004419A (es) 2022-08-08
IL292182A (en) 2022-06-01
CA3157716A1 (en) 2021-04-22
AU2020365518A1 (en) 2022-04-14
GB201914860D0 (en) 2019-11-27
JP2022551950A (ja) 2022-12-14
EP4045510A1 (en) 2022-08-24
WO2021074620A9 (en) 2021-06-17
EP4045510C0 (en) 2025-07-30
ES3047908T3 (en) 2025-12-05
ZA202203520B (en) 2025-09-25
US20240217987A1 (en) 2024-07-04
IL292182B1 (en) 2026-02-01
KR20220083761A (ko) 2022-06-20
US12528826B2 (en) 2026-01-20

Similar Documents

Publication Publication Date Title
EP4045510B1 (en) [1,4]oxazepino[2,3-c]quinolinone derivatives as blc6 inhibitors
US12486285B2 (en) BCL6 inhibitors
US11161839B2 (en) 2-quinolone derived inhibitors of BCL6
WO2020104820A1 (en) Substituted benzimidazolones as anti-cancer agents
US20240293392A1 (en) Inhibitor compounds
HK40081687B (en) [1,4]oxazepino[2,3‑c]quinolinone derivatives as blc6 inhibitors
HK40081687A (en) [1,4]oxazepino[2,3‑c]quinolinone derivatives as blc6 inhibitors
AU2022398373A1 (en) Indolines as protac compounds
EA047672B1 (ru) Производные [1,4]оксазепино[2,3-c]хинолинона в качестве ингибиторов bcl6
CA3037605C (en) Preparation and uses of pyrimidinone derivatives
HK40095873A (en) Bcl6 inhibitors
HK40046058A (en) Bcl6 inhibitors
HK40046058B (en) Bcl6 inhibitors
EA050300B1 (ru) Ингибиторы bcl6
CA3037605A1 (en) Preparation and uses of pyrimidinone derivatives