JP7660821B2 - 化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法 - Google Patents

化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法 Download PDF

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JP7660821B2
JP7660821B2 JP2023514610A JP2023514610A JP7660821B2 JP 7660821 B2 JP7660821 B2 JP 7660821B2 JP 2023514610 A JP2023514610 A JP 2023514610A JP 2023514610 A JP2023514610 A JP 2023514610A JP 7660821 B2 JP7660821 B2 JP 7660821B2
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cell
compound
mitochondria
cells
staining
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JPWO2022220163A1 (https=
JPWO2022220163A5 (https=
Inventor
美保 古江
純子 坂神
憲太郎 大橋
茂雄 高島
美和 前田
洋 竹森
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Nikon Corp
Tokai National Higher Education and Research System NUC
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Nikon Corp
Tokai National Higher Education and Research System NUC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2023514610A 2021-04-16 2022-03-31 化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法 Active JP7660821B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021070021 2021-04-16
JP2021070021 2021-04-16
PCT/JP2022/016836 WO2022220163A1 (ja) 2021-04-16 2022-03-31 化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法

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JPWO2022220163A1 JPWO2022220163A1 (https=) 2022-10-20
JPWO2022220163A5 JPWO2022220163A5 (https=) 2024-01-24
JP7660821B2 true JP7660821B2 (ja) 2025-04-14

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006056885A (ja) 1999-11-03 2006-03-02 Applera Corp 水溶性ローダミン色素およびその結合体
JP2010180409A (ja) 1997-09-23 2010-08-19 Molecular Probes Inc スルホン化キサンテン誘導体
JP2011506673A (ja) 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物
WO2013035767A1 (ja) 2011-09-07 2013-03-14 国立大学法人 東京大学 酸性環境検出蛍光プローブ
JP2018502581A (ja) 2015-01-06 2018-02-01 ルテリオン カンパニー リミテッドＬｕｔｅｒｉｏｎ Ｃｏ．， Ｌｔｄ． ルテリオンおよびその分離・培養方法
CN111004246A (zh) 2019-12-13 2020-04-14 山西大学 监测线粒体自噬的罗丹明类pH荧光探针及制备和应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010180409A (ja) 1997-09-23 2010-08-19 Molecular Probes Inc スルホン化キサンテン誘導体
JP2006056885A (ja) 1999-11-03 2006-03-02 Applera Corp 水溶性ローダミン色素およびその結合体
JP2011506673A (ja) 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物
WO2013035767A1 (ja) 2011-09-07 2013-03-14 国立大学法人 東京大学 酸性環境検出蛍光プローブ
JP2018502581A (ja) 2015-01-06 2018-02-01 ルテリオン カンパニー リミテッドＬｕｔｅｒｉｏｎ Ｃｏ．， Ｌｔｄ． ルテリオンおよびその分離・培養方法
CN111004246A (zh) 2019-12-13 2020-04-14 山西大学 监测线粒体自噬的罗丹明类pH荧光探针及制备和应用

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JPWO2022220163A1 (https=) 2022-10-20

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