JP7657213B2 - 抗メソテリンエリブリン抗体－薬物コンジュゲート及び使用方法 - Google Patents

抗メソテリンエリブリン抗体－薬物コンジュゲート及び使用方法 Download PDF

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JP7657213B2
JP7657213B2 JP2022525715A JP2022525715A JP7657213B2 JP 7657213 B2 JP7657213 B2 JP 7657213B2 JP 2022525715 A JP2022525715 A JP 2022525715A JP 2022525715 A JP2022525715 A JP 2022525715A JP 7657213 B2 JP7657213 B2 JP 7657213B2
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antibody
seq
cancer
antigen
amino acid
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JP2023500875A (ja
JP2023500875A5 (https=
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アール， エフ． アルボーン，
ジャレド スパイデル，
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2022525715A 2019-11-07 2020-11-06 抗メソテリンエリブリン抗体－薬物コンジュゲート及び使用方法 Active JP7657213B2 (ja)

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US201962932373P 2019-11-07 2019-11-07
US62/932,373 2019-11-07
PCT/IB2020/000917 WO2021090062A1 (en) 2019-11-07 2020-11-06 Anti-mesothelin eribulin antibody-drug conjugates and methods of use

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JP2023500875A JP2023500875A (ja) 2023-01-11
JP2023500875A5 JP2023500875A5 (https=) 2023-11-08
JP7657213B2 true JP7657213B2 (ja) 2025-04-04

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