JP7626577B2 - リガンド結合活性が調整可能なリガンド結合分子 - Google Patents

リガンド結合活性が調整可能なリガンド結合分子 Download PDF

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JP7626577B2
JP7626577B2 JP2018553014A JP2018553014A JP7626577B2 JP 7626577 B2 JP7626577 B2 JP 7626577B2 JP 2018553014 A JP2018553014 A JP 2018553014A JP 2018553014 A JP2018553014 A JP 2018553014A JP 7626577 B2 JP7626577 B2 JP 7626577B2
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ligand
antibody
seq
protease
binding molecule
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JPWO2018097308A1 (ja
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智之 井川
広幸 石川
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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JP2018553014A 2016-11-28 2017-11-28 リガンド結合活性が調整可能なリガンド結合分子 Active JP7626577B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023038624A JP7671794B2 (ja) 2016-11-28 2023-03-13 リガンド結合活性が調整可能なリガンド結合分子
JP2024226961A JP2025041812A (ja) 2016-11-28 2024-12-24 リガンド結合活性が調整可能なリガンド結合分子

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JP2016229882 2016-11-28
JP2016229882 2016-11-28
PCT/JP2017/042570 WO2018097308A1 (ja) 2016-11-28 2017-11-28 リガンド結合活性が調整可能なリガンド結合分子

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JP7626577B2 true JP7626577B2 (ja) 2025-02-07

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JP2018553014A Active JP7626577B2 (ja) 2016-11-28 2017-11-28 リガンド結合活性が調整可能なリガンド結合分子
JP2023038624A Active JP7671794B2 (ja) 2016-11-28 2023-03-13 リガンド結合活性が調整可能なリガンド結合分子
JP2024226961A Pending JP2025041812A (ja) 2016-11-28 2024-12-24 リガンド結合活性が調整可能なリガンド結合分子

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JP2024226961A Pending JP2025041812A (ja) 2016-11-28 2024-12-24 リガンド結合活性が調整可能なリガンド結合分子

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US (2) US12060654B2 (https=)
EP (1) EP3546480A4 (https=)
JP (3) JP7626577B2 (https=)
KR (2) KR20230073346A (https=)
CN (1) CN110214151A (https=)
AU (1) AU2017364818C1 (https=)
BR (1) BR112019008265A2 (https=)
CA (1) CA3039316A1 (https=)
IL (1) IL266827B2 (https=)
MX (3) MX2019005947A (https=)
TW (2) TW202235438A (https=)
WO (1) WO2018097308A1 (https=)

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BR112019008727A2 (pt) 2016-11-28 2019-07-16 Chugai Seiyaku Kabushiki Kaisha domínio de ligação ao antígeno, e polipeptídeo incluindo seção de transporte
JP7626577B2 (ja) 2016-11-28 2025-02-07 中外製薬株式会社 リガンド結合活性が調整可能なリガンド結合分子
TWI880235B (zh) * 2017-11-28 2025-04-11 日商中外製藥股份有限公司 可調整配體結合活性的配體結合分子
JP7482630B2 (ja) * 2017-11-28 2024-05-14 中外製薬株式会社 抗原結合ドメインおよび運搬部分を含むポリペプチド
WO2019222296A1 (en) * 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin 12 polypeptides and methods of use thereof
JP7414736B2 (ja) 2018-05-30 2024-01-16 中外製薬株式会社 アグリカン結合ドメインおよび運搬部分を含むポリペプチド
US20210253672A1 (en) * 2018-05-30 2021-08-19 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule containing single domain antibody
WO2020023702A1 (en) 2018-07-25 2020-01-30 AskGene Pharma, Inc. Novel il-21 prodrugs and methods of use thereof
MX2021003580A (es) * 2018-09-28 2021-10-13 Pf Medicament Nuevas inmunocitocinas para el tratamiento contra el cancer.
KR20210081372A (ko) * 2018-10-22 2021-07-01 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 절단 가능한 cxcr3의 활성제 및 이의 사용 방법
US20220017585A1 (en) * 2018-12-04 2022-01-20 Chugai Seiyaku Kabushiki Kaisha Cxcr3 ligand
WO2020246563A1 (ja) 2019-06-05 2020-12-10 中外製薬株式会社 抗体切断部位結合分子
CN114127277A (zh) * 2019-06-05 2022-03-01 中外制药株式会社 蛋白酶底物和包含蛋白酶切割序列的多肽
CA3141626A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
US20220281934A1 (en) * 2019-08-29 2022-09-08 Antagonis Biotherapeutics Gmbh T-cell mobilizing cxcl10 mutant with increased glycosaminoglycan binding affinity
CA3165927A1 (en) 2020-01-11 2021-07-15 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
EP4093875A4 (en) * 2020-01-20 2024-02-28 Chugai Seiyaku Kabushiki Kaisha Ligand-binding fusion proteins
EP3889183A1 (en) * 2020-04-01 2021-10-06 Pierre Fabre Medicament A protein complex comprising an immunocytokine
CN117957258A (zh) * 2021-07-19 2024-04-30 中外制药株式会社 利用融合多肽的蛋白酶介导的靶向特异性细胞因子递送
EP4455158A4 (en) 2021-12-23 2026-04-15 Chugai Pharmaceutical Co Ltd CXCR3 LIGAND WITH ENHANCED CXCR3-EXPRESSING CELL MIGRATION ACTIVITY
CN120112547A (zh) 2022-11-16 2025-06-06 瑞泽恩制药公司 包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白

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