JP7614185B2 - アリールまたはヘテロアリール誘導体 - Google Patents

アリールまたはヘテロアリール誘導体 Download PDF

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JP7614185B2
JP7614185B2 JP2022515435A JP2022515435A JP7614185B2 JP 7614185 B2 JP7614185 B2 JP 7614185B2 JP 2022515435 A JP2022515435 A JP 2022515435A JP 2022515435 A JP2022515435 A JP 2022515435A JP 7614185 B2 JP7614185 B2 JP 7614185B2
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oxybenzonitrile
pyrimidin
methyl
aminoethyl
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JPWO2021210650A1 (https=
Inventor
栄 杉山
卓也 横坂
邦夫 南園
旭 河名
俊幸 金子
明伸 丸山
浩介 佐々木
信之介 細田
正樹 小清水
進 竹内
賢太 加藤
チャッカ，ナガスリー
エム． ジョンソン，ブレット
ディー． ホワイト，ライアン
ヂャオ，ウェイ
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Teijin Pharma Ltd
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Teijin Pharma Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107474A1 (en) 2010-03-01 2011-09-09 Sanofi-Aventis Derivatives of aminoindanes, their preparation and their application in therapeutics
WO2012037351A1 (en) 2010-09-17 2012-03-22 Glaxosmithkline Llc Compounds
WO2013045519A1 (en) 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
WO2014192865A1 (ja) 2013-05-30 2014-12-04 大日本住友製薬株式会社 フェニルピペラジン誘導体
WO2019081637A1 (en) 2017-10-27 2019-05-02 Boehringer Ingelheim International Gmbh CARBONYL PYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USES AS TRPC6 INHIBITORS
WO2019208812A1 (ja) 2018-04-27 2019-10-31 国立大学法人大阪大学 ベンゾイソオキサゾール化合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5747915B2 (https=) * 1974-04-17 1982-10-13
JPS58427B2 (ja) * 1974-07-25 1983-01-06 武田薬品工業株式会社 ４−（ピリジンカルボニル）フェニル−１，２，４−トリアゾ−ル誘導体の製造法
FR2285125A1 (fr) * 1974-09-17 1976-04-16 Takeda Chemical Industries Ltd Derives de 1,2,4-triazole
US4315926A (en) * 1979-12-26 1982-02-16 Ciba-Geigy Corporation Dibenz[c,e]azepines
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
JP5453431B2 (ja) * 2008-09-08 2014-03-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピラゾロピリミジン及びｃｎｓ障害の治療のためのそれらの使用
WO2012037349A2 (en) 2010-09-17 2012-03-22 Glaxosmithkline Llc Compounds
WO2014016766A1 (en) 2012-07-25 2014-01-30 Glenmark Pharmaceuticals S.A. Guanidine derivatives as trpc modulators
CN104292233B (zh) 2014-10-09 2016-03-16 武汉大学 一种吡唑并[1,5-a]嘧啶衍生物及其抗肿瘤用途
MX395250B (es) * 2015-03-18 2025-03-25 Fmc Corp Star Derivados de pirimidiniloxipiridina sustituidos como herbicidas.
CN106317050B (zh) 2016-08-24 2018-11-23 烟台大学 一种苯基噻唑衍生物及其制备方法与应用
CN107253952B (zh) 2017-08-01 2019-07-30 烟台大学 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途
HRP20250272T1 (hr) 2017-10-19 2025-04-25 Teijin Pharma Limited Derivati benzimidazola i njihova uporaba
EP3723754A4 (en) * 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. IMIDAZO [1,2-C] QUINAZOLINE-5-AMINE COMPOUNDS WITH PROPERTIES OF A2A ANTAGONIST
JP7291711B2 (ja) 2018-02-15 2023-06-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐｃ６阻害剤
CN111868055B (zh) 2018-02-16 2024-03-08 勃林格殷格翰国际有限公司 Trpc6的抑制剂

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107474A1 (en) 2010-03-01 2011-09-09 Sanofi-Aventis Derivatives of aminoindanes, their preparation and their application in therapeutics
WO2012037351A1 (en) 2010-09-17 2012-03-22 Glaxosmithkline Llc Compounds
WO2013045519A1 (en) 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
WO2014192865A1 (ja) 2013-05-30 2014-12-04 大日本住友製薬株式会社 フェニルピペラジン誘導体
WO2019081637A1 (en) 2017-10-27 2019-05-02 Boehringer Ingelheim International Gmbh CARBONYL PYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USES AS TRPC6 INHIBITORS
WO2019208812A1 (ja) 2018-04-27 2019-10-31 国立大学法人大阪大学 ベンゾイソオキサゾール化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARINHO,E. et al.，The reaction of anthranilonitrile and triethylorthoformate revisited: formation of dimeric and trime，Tetrahedron，2010年，Vol.66, No.45，pp.8681-8689，DOI 10.1016/j.tet.2010.09.013
ZHANG,L. et al.，Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C-H/C-H Coupling of Phenols with，ACS Catalysis，2018年，Vol.8, No.9，pp.8324-8335，DOI 10.1021/acscatal.8b02816

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