JP7608348B2 - 選択されたニューロン細胞集団における遺伝子発現を選択的に調節するための人工発現コンストラクト - Google Patents
選択されたニューロン細胞集団における遺伝子発現を選択的に調節するための人工発現コンストラクト Download PDFInfo
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- JP7608348B2 JP7608348B2 JP2021547404A JP2021547404A JP7608348B2 JP 7608348 B2 JP7608348 B2 JP 7608348B2 JP 2021547404 A JP2021547404 A JP 2021547404A JP 2021547404 A JP2021547404 A JP 2021547404A JP 7608348 B2 JP7608348 B2 JP 7608348B2
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- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024220548A JP7909577B2 (ja) | 2019-02-15 | 2024-12-17 | 選択されたニューロン細胞集団における遺伝子発現を選択的に調節するための人工発現コンストラクト |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806686P | 2019-02-15 | 2019-02-15 | |
| US201962806660P | 2019-02-15 | 2019-02-15 | |
| US62/806,686 | 2019-02-15 | ||
| US62/806,660 | 2019-02-15 | ||
| US201962874859P | 2019-07-16 | 2019-07-16 | |
| US62/874,859 | 2019-07-16 | ||
| PCT/US2020/018416 WO2020168279A2 (en) | 2019-02-15 | 2020-02-14 | Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024220548A Division JP7909577B2 (ja) | 2019-02-15 | 2024-12-17 | 選択されたニューロン細胞集団における遺伝子発現を選択的に調節するための人工発現コンストラクト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022520437A JP2022520437A (ja) | 2022-03-30 |
| JP2022520437A5 JP2022520437A5 (enExample) | 2022-12-28 |
| JP7608348B2 true JP7608348B2 (ja) | 2025-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547404A Active JP7608348B2 (ja) | 2019-02-15 | 2020-02-14 | 選択されたニューロン細胞集団における遺伝子発現を選択的に調節するための人工発現コンストラクト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12702722B2 (enExample) |
| EP (1) | EP3923995A4 (enExample) |
| JP (1) | JP7608348B2 (enExample) |
| AU (1) | AU2020223367B2 (enExample) |
| CA (1) | CA3142948A1 (enExample) |
| WO (1) | WO2020168279A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7590962B2 (ja) | 2018-11-05 | 2024-11-27 | アレン インスティテュート | 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| CA3142948A1 (en) | 2019-02-15 | 2020-08-20 | Allen Institute | Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations |
| JP7721568B2 (ja) * | 2020-04-21 | 2025-08-12 | アレン インスティテュート | 新皮質層5グルタミン酸作動性ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物 |
| EP4244366A4 (en) * | 2020-11-10 | 2024-12-25 | Allen Institute | Artificial expression constructs for modulating gene expression in chandelier cells |
| US20240182923A1 (en) * | 2021-03-30 | 2024-06-06 | Allen Institute | Artificial expression constructs for modulating gene expression in claustrum neurons |
| AU2022276538A1 (en) * | 2021-05-21 | 2023-11-09 | Allen Institute | Artificial expression constructs for modulating gene expression in neurons within the thalamus |
| CA3233342A1 (en) * | 2021-10-05 | 2023-04-13 | Tanya DAIGLE | Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type |
| EP4735613A1 (en) * | 2023-06-28 | 2026-05-06 | Allen Institute | Artificial expression constructs for modulating gene expression in cardiomyocytes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017100671A1 (en) | 2015-12-11 | 2017-06-15 | California Institute Of Technology | TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs) |
| JP2022513426A (ja) | 2018-11-05 | 2022-02-08 | アレン インスティテュート | 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
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| DE69918090T2 (de) * | 1998-04-24 | 2005-06-16 | University Of Florida, Gainesville | Rekombinanter adeno-assoziierter viraler vektor, der alpha-1 antitrypsin kodiert, zur gentherapie |
| US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| EP2028268A1 (en) | 2007-08-20 | 2009-02-25 | Université Libre De Bruxelles | Generation of neuronal cells from pluripotent stem cells |
| EP3702460A1 (en) * | 2010-11-12 | 2020-09-02 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9284575B2 (en) * | 2012-03-06 | 2016-03-15 | Duke University | Synthetic regulation of gene expression |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| US9579399B2 (en) | 2012-08-27 | 2017-02-28 | Friedrich Miescher Institute For Biomedical Research | Retinal OFF circuit-specific promoter |
| EP2922972B1 (en) | 2012-11-26 | 2017-04-26 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Colorectal cancer classification with differential prognosis and personalized therapeutic responses |
| US20150376612A1 (en) | 2014-06-10 | 2015-12-31 | The General Hospital Corporation | CCCTC-Binding Factor (CTCF) RNA Interactome |
| CL2014003590A1 (es) | 2014-12-30 | 2015-07-10 | Univ Chile | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
| US10682424B2 (en) | 2015-03-31 | 2020-06-16 | New York University | Compositions and method for reducing seizures |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| EP3416663B1 (en) * | 2016-02-18 | 2021-04-14 | The Penn State Research Foundation | Generating gabaergic neurons in brains |
| CN117821509A (zh) | 2017-04-03 | 2024-04-05 | 编码治疗公司 | 组织选择性转基因表达 |
| CA3142948A1 (en) | 2019-02-15 | 2020-08-20 | Allen Institute | Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations |
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2020
- 2020-02-14 CA CA3142948A patent/CA3142948A1/en active Pending
- 2020-02-14 US US17/431,079 patent/US12702722B2/en active Active
- 2020-02-14 EP EP20756018.6A patent/EP3923995A4/en active Pending
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- 2020-02-14 AU AU2020223367A patent/AU2020223367B2/en active Active
- 2020-02-14 WO PCT/US2020/018416 patent/WO2020168279A2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017100671A1 (en) | 2015-12-11 | 2017-06-15 | California Institute Of Technology | TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs) |
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| JP2022520437A (ja) | 2022-03-30 |
| US12702722B2 (en) | 2026-08-11 |
| EP3923995A2 (en) | 2021-12-22 |
| WO2020168279A2 (en) | 2020-08-20 |
| EP3923995A4 (en) | 2023-05-17 |
| AU2020223367A1 (en) | 2021-10-07 |
| WO2020168279A3 (en) | 2020-09-24 |
| JP2025041709A (ja) | 2025-03-26 |
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