AU2020223367B2 - Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations - Google Patents

Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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Publication number
AU2020223367B2
AU2020223367B2 AU2020223367A AU2020223367A AU2020223367B2 AU 2020223367 B2 AU2020223367 B2 AU 2020223367B2 AU 2020223367 A AU2020223367 A AU 2020223367A AU 2020223367 A AU2020223367 A AU 2020223367A AU 2020223367 B2 AU2020223367 B2 AU 2020223367B2
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ehgt
neuron
vector
cell
cells
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AU2020223367A1 (en
Inventor
Tanya DAIGLE
Lucas T. GRAYBUCK
Erik HESS
Edward Sebastian LEIN
Boaz P. LEVI
John K. Mich
Bosiljka Tasic
Jonathan Ting
Hongkui Zeng
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Allen Institute
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Allen Institute
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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AU2020223367A 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations Active AU2020223367B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962806686P 2019-02-15 2019-02-15
US201962806660P 2019-02-15 2019-02-15
US62/806,686 2019-02-15
US62/806,660 2019-02-15
US201962874859P 2019-07-16 2019-07-16
US62/874,859 2019-07-16
PCT/US2020/018416 WO2020168279A2 (en) 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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AU2020223367B2 true AU2020223367B2 (en) 2026-06-11

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US12702722B2 (en) 2026-08-11
EP3923995A2 (en) 2021-12-22
WO2020168279A2 (en) 2020-08-20
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