CA3142948A1 - Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations - Google Patents

Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations Download PDF

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Publication number
CA3142948A1
CA3142948A1 CA3142948A CA3142948A CA3142948A1 CA 3142948 A1 CA3142948 A1 CA 3142948A1 CA 3142948 A CA3142948 A CA 3142948A CA 3142948 A CA3142948 A CA 3142948A CA 3142948 A1 CA3142948 A1 CA 3142948A1
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Prior art keywords
ehgt
expression construct
bghpa
vector
wpre3
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CA3142948A
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English (en)
French (fr)
Inventor
Jonathan Ting
Boaz P. LEVI
Bosiljka Tasic
John K. Mich
Erik HESS
Edward Sebastian LEIN
Lucas T. GRAYBUCK
Tanya DAIGLE
Hongkui Zeng
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Allen Institute
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Allen Institute
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
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CA3142948A 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations Pending CA3142948A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962806686P 2019-02-15 2019-02-15
US201962806660P 2019-02-15 2019-02-15
US62/806,686 2019-02-15
US62/806,660 2019-02-15
US201962874859P 2019-07-16 2019-07-16
US62/874,859 2019-07-16
PCT/US2020/018416 WO2020168279A2 (en) 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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CA3142948A1 true CA3142948A1 (en) 2020-08-20

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CA3142948A Pending CA3142948A1 (en) 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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US (1) US12702722B2 (enExample)
EP (1) EP3923995A4 (enExample)
JP (1) JP7608348B2 (enExample)
AU (1) AU2020223367B2 (enExample)
CA (1) CA3142948A1 (enExample)
WO (1) WO2020168279A2 (enExample)

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JP7590962B2 (ja) 2018-11-05 2024-11-27 アレン インスティテュート 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
CA3142948A1 (en) 2019-02-15 2020-08-20 Allen Institute Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations
JP7721568B2 (ja) * 2020-04-21 2025-08-12 アレン インスティテュート 新皮質層５グルタミン酸作動性ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物
EP4244366A4 (en) * 2020-11-10 2024-12-25 Allen Institute Artificial expression constructs for modulating gene expression in chandelier cells
US20240182923A1 (en) * 2021-03-30 2024-06-06 Allen Institute Artificial expression constructs for modulating gene expression in claustrum neurons
AU2022276538A1 (en) * 2021-05-21 2023-11-09 Allen Institute Artificial expression constructs for modulating gene expression in neurons within the thalamus
CA3233342A1 (en) * 2021-10-05 2023-04-13 Tanya DAIGLE Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type
EP4735613A1 (en) * 2023-06-28 2026-05-06 Allen Institute Artificial expression constructs for modulating gene expression in cardiomyocytes

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CA3142948A1 (en) 2019-02-15 2020-08-20 Allen Institute Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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US12702722B2 (en) 2026-08-11
EP3923995A2 (en) 2021-12-22
WO2020168279A2 (en) 2020-08-20
JP7608348B2 (ja) 2025-01-06
EP3923995A4 (en) 2023-05-17
AU2020223367A1 (en) 2021-10-07
WO2020168279A3 (en) 2020-09-24
JP2025041709A (ja) 2025-03-26
AU2020223367B2 (en) 2026-06-11
US20220249703A1 (en) 2022-08-11

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