JP7593939B2 - 抗ｍｅｒｔｋ抗体及びその使用方法 - Google Patents

抗ｍｅｒｔｋ抗体及びその使用方法 Download PDF

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JP7593939B2
JP7593939B2 JP2021560968A JP2021560968A JP7593939B2 JP 7593939 B2 JP7593939 B2 JP 7593939B2 JP 2021560968 A JP2021560968 A JP 2021560968A JP 2021560968 A JP2021560968 A JP 2021560968A JP 7593939 B2 JP7593939 B2 JP 7593939B2
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seq
amino acid
mertk
acid sequence
antibody
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JPWO2020214995A5 (https=
JP2022529154A (ja
JP2022529154A5 (https=
Inventor
ウェイ－チン リャン，
ウェイユー リン，
ヤン ウー，
ミンホン ヤン，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021560968A 2019-04-19 2020-04-17 抗ｍｅｒｔｋ抗体及びその使用方法 Active JP7593939B2 (ja)

Priority Applications (1)

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JP2024203545A JP2025037921A (ja) 2019-04-19 2024-11-21 抗ｍｅｒｔｋ抗体及びその使用方法

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US201962836580P 2019-04-19 2019-04-19
US62/836,580 2019-04-19
US201962890858P 2019-08-23 2019-08-23
US62/890,858 2019-08-23
PCT/US2020/028828 WO2020214995A1 (en) 2019-04-19 2020-04-17 Anti-mertk antibodies and their methods of use

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JP2022529154A JP2022529154A (ja) 2022-06-17
JPWO2020214995A5 JPWO2020214995A5 (https=) 2023-04-24
JP2022529154A5 JP2022529154A5 (https=) 2023-04-24
JP7593939B2 true JP7593939B2 (ja) 2024-12-03

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US (2) US20220135701A1 (https=)
EP (1) EP3956364A1 (https=)
JP (2) JP7593939B2 (https=)
KR (1) KR20220002967A (https=)
CN (1) CN114364703A (https=)
AU (1) AU2020258480B2 (https=)
BR (1) BR112021020867A2 (https=)
CA (1) CA3134522A1 (https=)
IL (1) IL287282A (https=)
MX (1) MX2021012692A (https=)
TW (1) TW202043291A (https=)
WO (1) WO2020214995A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023506465A (ja) 2019-12-13 2023-02-16 アレクトル エルエルシー 抗ＭｅｒＴＫ抗体及びその使用方法
JP2023519962A (ja) * 2020-03-31 2023-05-15 アレクトル エルエルシー 抗ｍｅｒｔｋ抗体及びその使用方法
AR123855A1 (es) * 2020-10-20 2023-01-18 Genentech Inc Anticuerpos anti-mertk conjugados con peg y métodos de uso
US20240279341A1 (en) 2021-06-16 2024-08-22 Alector Llc Bispecific anti-mertk and anti-pdl1 antibodies and methods of use thereof
JP2024527493A (ja) 2021-06-16 2024-07-25 アレクトル エルエルシー 一価の抗ＭｅｒＴＫ抗体及びその使用方法
EP4417625A4 (en) * 2021-10-15 2026-01-14 Chiome Bioscience Inc ANTIBODY OR FRAGMENT THEREOF THAT BINDS SPECIFICALLY TO MERTK, AND ANTITUMORAL AGENT
WO2024020063A2 (en) * 2022-07-19 2024-01-25 La Jolla Institute For Immunology Anti-hrf antibodies
CN120484126B (zh) * 2022-07-28 2025-11-18 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途
CN121673366A (zh) * 2026-02-10 2026-03-17 吉林农业大学 小分子肽及应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2018504105A (ja) 2014-12-22 2018-02-15 ザ ロックフェラー ユニバーシティー 抗ｍｅｒｔｋアゴニスト抗体及びその使用
WO2019005756A1 (en) 2017-06-28 2019-01-03 The Rockefeller University CONJUGATES AGONIST ANTIBODY ANTI-MERTK-MEDICINE
JP2022512642A (ja) 2018-10-09 2022-02-07 ブリストル－マイヤーズ スクイブ カンパニー がんを治療するための抗ＭｅｒＴＫ抗体

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