JP7584894B2 - エキセンディン(9-39)の緩衝製剤 - Google Patents

エキセンディン(9-39)の緩衝製剤 Download PDF

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Publication number
JP7584894B2
JP7584894B2 JP2019527188A JP2019527188A JP7584894B2 JP 7584894 B2 JP7584894 B2 JP 7584894B2 JP 2019527188 A JP2019527188 A JP 2019527188A JP 2019527188 A JP2019527188 A JP 2019527188A JP 7584894 B2 JP7584894 B2 JP 7584894B2
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JP
Japan
Prior art keywords
exendin
pharmaceutical formulation
liquid pharmaceutical
formulation
pharma
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Active
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JP2019527188A
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English (en)
Japanese (ja)
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JP2019535734A (ja
JP2019535734A5 (enExample
Inventor
シャオフェン・シオン
デブラ・オディンク
コリーン・エム・クレイグ
クリスティン・エム・エヌ・スミス
トレイシー・エル・マクローリン
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Eiger Biopharmaceuticals Inc
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Eiger Biopharmaceuticals Inc
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Application filed by Eiger Biopharmaceuticals Inc filed Critical Eiger Biopharmaceuticals Inc
Publication of JP2019535734A publication Critical patent/JP2019535734A/ja
Publication of JP2019535734A5 publication Critical patent/JP2019535734A5/ja
Priority to JP2022123899A priority Critical patent/JP2022153624A/ja
Priority to JP2024100740A priority patent/JP2024150450A/ja
Application granted granted Critical
Publication of JP7584894B2 publication Critical patent/JP7584894B2/ja
Priority to JP2025185576A priority patent/JP2026048629A/ja
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019527188A 2016-11-21 2017-11-21 エキセンディン(9-39)の緩衝製剤 Active JP7584894B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022123899A JP2022153624A (ja) 2016-11-21 2022-08-03 エキセンディン(9-39)の緩衝製剤
JP2024100740A JP2024150450A (ja) 2016-11-21 2024-06-21 エキセンディン(9-39)の緩衝製剤
JP2025185576A JP2026048629A (ja) 2016-11-21 2025-11-04 エキセンディン(9-39)の緩衝製剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662424979P 2016-11-21 2016-11-21
US62/424,979 2016-11-21
US201762517065P 2017-06-08 2017-06-08
US62/517,065 2017-06-08
PCT/US2017/062838 WO2018094404A1 (en) 2016-11-21 2017-11-21 Buffered formulations of exendin (9-39)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022123899A Division JP2022153624A (ja) 2016-11-21 2022-08-03 エキセンディン(9-39)の緩衝製剤

Publications (3)

Publication Number Publication Date
JP2019535734A JP2019535734A (ja) 2019-12-12
JP2019535734A5 JP2019535734A5 (enExample) 2020-12-24
JP7584894B2 true JP7584894B2 (ja) 2024-11-18

Family

ID=62145888

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019527188A Active JP7584894B2 (ja) 2016-11-21 2017-11-21 エキセンディン(9-39)の緩衝製剤
JP2022123899A Withdrawn JP2022153624A (ja) 2016-11-21 2022-08-03 エキセンディン(9-39)の緩衝製剤
JP2024100740A Pending JP2024150450A (ja) 2016-11-21 2024-06-21 エキセンディン(9-39)の緩衝製剤
JP2025185576A Pending JP2026048629A (ja) 2016-11-21 2025-11-04 エキセンディン(9-39)の緩衝製剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2022123899A Withdrawn JP2022153624A (ja) 2016-11-21 2022-08-03 エキセンディン(9-39)の緩衝製剤
JP2024100740A Pending JP2024150450A (ja) 2016-11-21 2024-06-21 エキセンディン(9-39)の緩衝製剤
JP2025185576A Pending JP2026048629A (ja) 2016-11-21 2025-11-04 エキセンディン(9-39)の緩衝製剤

Country Status (20)

Country Link
US (4) US11020484B2 (enExample)
EP (2) EP3541366B1 (enExample)
JP (4) JP7584894B2 (enExample)
CN (1) CN110267648A (enExample)
AU (3) AU2017361539B2 (enExample)
CA (1) CA3043899A1 (enExample)
CL (1) CL2019001366A1 (enExample)
DK (1) DK3541366T3 (enExample)
ES (1) ES3014024T3 (enExample)
FI (1) FI3541366T3 (enExample)
HR (1) HRP20250278T1 (enExample)
HU (1) HUE070730T2 (enExample)
IL (1) IL266568B2 (enExample)
LT (1) LT3541366T (enExample)
PL (1) PL3541366T3 (enExample)
PT (1) PT3541366T (enExample)
RS (1) RS66595B1 (enExample)
SI (1) SI3541366T1 (enExample)
SM (1) SMT202500120T1 (enExample)
WO (1) WO2018094404A1 (enExample)

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LT3456340T (lt) 2007-01-08 2022-05-10 The Trustees Of The University Of Pennsylvania Glp-1 receptoriaus antagonistas, skirtas įgimto hiperinsulinizmo gydymui
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
SMT202100668T1 (it) 2015-05-22 2022-01-10 Univ Leland Stanford Junior Trattamento dell'ipoglicemia post-bariatrica con antagonisti del glp-1
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
JP7584894B2 (ja) 2016-11-21 2024-11-18 アイガー・バイオファーマシューティカルズ・インコーポレイテッド エキセンディン(9-39)の緩衝製剤
ES2894629T3 (es) 2017-06-16 2022-02-15 Zealand Pharma As Pautas posológicas para la administración de análogos del péptido 2 similar al glucagón (GLP-2)
EP3628683A1 (en) * 2018-09-28 2020-04-01 Zealand Pharma A/S Formulations of glucagon-like-peptide-2 (glp-2) analogues
CA3115527A1 (en) * 2018-10-15 2020-04-23 Eiger Biopharmaceuticals, Inc. Avexitide for the treatment of hyperinsulinemic hypoglycemia
MX2022014090A (es) 2020-05-12 2023-02-27 Regeneron Pharma Anticuerpos antagonistas anti-glp1r y metodos de uso de los mismos.
US20240307501A1 (en) 2021-06-21 2024-09-19 Eiger Biopharmaceuticals, Inc. Treatment of congenital hyperinsulinism with avexitide
WO2023229987A1 (en) * 2022-05-25 2023-11-30 Neuvian LLC Vaginal care compositions comprising exosomes and its uses for improving vaginal health
CN116606367A (zh) * 2022-05-31 2023-08-18 南京盛德瑞尔医药科技有限公司 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物
WO2024220962A1 (en) * 2023-04-21 2024-10-24 The Board Of Trustees Of The Leland Stanford Junior University Glp-1r antagonism to improve nutrition following gastrointestinal surgery

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US20080269130A1 (en) 2007-01-08 2008-10-30 Doris Stoffers Methods and compositions for treating hypoglycemic disorders

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2002534450A (ja) 1999-01-14 2002-10-15 アミリン・ファーマシューティカルズ,インコーポレイテッド 新規なエキセンジンアゴニスト製剤とその投与方法
US20080269130A1 (en) 2007-01-08 2008-10-30 Doris Stoffers Methods and compositions for treating hypoglycemic disorders

Also Published As

Publication number Publication date
HRP20250278T1 (hr) 2025-04-25
EP3541366A1 (en) 2019-09-25
DK3541366T3 (da) 2025-03-03
HUE070730T2 (hu) 2025-06-28
FI3541366T3 (fi) 2025-03-06
WO2018094404A1 (en) 2018-05-24
US11738086B2 (en) 2023-08-29
EP3541366A4 (en) 2020-08-05
PL3541366T3 (pl) 2025-04-28
US11020484B2 (en) 2021-06-01
RS66595B1 (sr) 2025-04-30
EP3541366B1 (en) 2024-12-25
AU2017361539A1 (en) 2019-07-04
JP2026048629A (ja) 2026-03-17
AU2017361539B2 (en) 2023-06-29
US20260034221A1 (en) 2026-02-05
AU2023237119B2 (en) 2025-04-10
PT3541366T (pt) 2025-03-14
US20210315995A1 (en) 2021-10-14
SI3541366T1 (sl) 2025-05-30
CA3043899A1 (en) 2018-05-24
LT3541366T (lt) 2025-03-10
IL266568B1 (en) 2024-05-01
JP2019535734A (ja) 2019-12-12
CN110267648A (zh) 2019-09-20
BR112019010236A2 (pt) 2019-08-20
IL266568B2 (en) 2024-09-01
JP2022153624A (ja) 2022-10-12
SMT202500120T1 (it) 2025-05-12
IL266568A (en) 2019-07-31
JP2024150450A (ja) 2024-10-23
ES3014024T3 (en) 2025-04-16
AU2025205195A1 (en) 2025-07-24
US20240042035A1 (en) 2024-02-08
CL2019001366A1 (es) 2019-11-08
AU2023237119A1 (en) 2023-10-19
US20200069802A1 (en) 2020-03-05
EP4591853A1 (en) 2025-07-30

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