JP7576539B2 - イオンチャネルモジュレーター - Google Patents

イオンチャネルモジュレーター Download PDF

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Publication number
JP7576539B2
JP7576539B2 JP2021517348A JP2021517348A JP7576539B2 JP 7576539 B2 JP7576539 B2 JP 7576539B2 JP 2021517348 A JP2021517348 A JP 2021517348A JP 2021517348 A JP2021517348 A JP 2021517348A JP 7576539 B2 JP7576539 B2 JP 7576539B2
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Japan
Prior art keywords
mmol
methyl
mixture
give
phenyl
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Japanese (ja)
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JP2022502442A (ja
JP2022502442A5 (enExample
Inventor
キラン レディ，
ボテッラ， ガブリエル マルティネス
アンドリュー マーク グリフィン，
ブライアン エドワード マロン，
Original Assignee
プラクシス プレシジョン メディシンズ， インコーポレイテッド
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Publication of JP2022502442A publication Critical patent/JP2022502442A/ja
Publication of JP2022502442A5 publication Critical patent/JP2022502442A5/ja
Priority to JP2024000336A priority Critical patent/JP2024019735A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2021517348A 2018-09-28 2019-09-27 イオンチャネルモジュレーター Active JP7576539B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024000336A JP2024019735A (ja) 2018-09-28 2024-01-04 イオンチャネルモジュレーター

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862738508P 2018-09-28 2018-09-28
US62/738,508 2018-09-28
PCT/US2019/053467 WO2020069322A1 (en) 2018-09-28 2019-09-27 Ion channel modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024000336A Division JP2024019735A (ja) 2018-09-28 2024-01-04 イオンチャネルモジュレーター

Publications (3)

Publication Number Publication Date
JP2022502442A JP2022502442A (ja) 2022-01-11
JP2022502442A5 JP2022502442A5 (enExample) 2022-10-05
JP7576539B2 true JP7576539B2 (ja) 2024-10-31

Family

ID=69949703

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021517348A Active JP7576539B2 (ja) 2018-09-28 2019-09-27 イオンチャネルモジュレーター
JP2024000336A Pending JP2024019735A (ja) 2018-09-28 2024-01-04 イオンチャネルモジュレーター

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024000336A Pending JP2024019735A (ja) 2018-09-28 2024-01-04 イオンチャネルモジュレーター

Country Status (12)

Country Link
US (1) US12479844B2 (enExample)
EP (1) EP3856193A4 (enExample)
JP (2) JP7576539B2 (enExample)
KR (1) KR102842377B1 (enExample)
CN (1) CN113573713A (enExample)
AU (2) AU2019346635A1 (enExample)
BR (1) BR112021005913A2 (enExample)
CA (1) CA3142470A1 (enExample)
EA (2) EA202092908A1 (enExample)
IL (1) IL281946A (enExample)
MX (1) MX2021003634A (enExample)
WO (1) WO2020069322A1 (enExample)

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US11492345B2 (en) 2017-02-13 2022-11-08 Praxis Precision Medicines, Inc. Compounds and their methods of use
WO2018187480A1 (en) 2017-04-04 2018-10-11 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11278535B2 (en) 2017-08-15 2022-03-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
MX2020012838A (es) 2018-05-30 2021-07-16 Praxis Prec Medicines Inc Moduladores de los canales ionicos.
EA202092908A1 (ru) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. Модуляторы ионных каналов
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
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US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
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US20250145637A1 (en) 2021-08-10 2025-05-08 Jiangsu Hengrui Pharmaceuticals Co. Ltd. Sulfonamide derivative, preparation method therefor and medical use thereof
KR20250005348A (ko) 2022-04-26 2025-01-09 프락시스 프리시젼 메디신즈, 인크. 신경 장애의 치료
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
KR20250173086A (ko) 2024-05-31 2025-12-10 더웨이브컨설팅 주식회사 이온 채널 조절 활성을 갖는 반도비탈거미 유래 펩타이드 및 이의 용도
WO2026082004A1 (zh) * 2024-10-14 2026-04-23 上海京新生物医药有限公司 稠合杂芳基衍生物及其制备方法与应用

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Also Published As

Publication number Publication date
CN113573713A (zh) 2021-10-29
EP3856193A4 (en) 2022-08-31
AU2025204027A9 (en) 2026-03-19
EA202092908A1 (ru) 2021-05-14
JP2022502442A (ja) 2022-01-11
JP2024019735A (ja) 2024-02-09
US12479844B2 (en) 2025-11-25
CA3142470A1 (en) 2020-04-02
EP3856193A1 (en) 2021-08-04
KR20210113974A (ko) 2021-09-17
MX2021003634A (es) 2021-07-16
AU2019346635A1 (en) 2021-05-20
IL281946A (en) 2021-05-31
EA202190879A1 (ru) 2021-08-16
WO2020069322A1 (en) 2020-04-02
AU2025204027A1 (en) 2025-06-19
BR112021005913A2 (pt) 2021-06-29
KR102842377B1 (ko) 2025-08-06
US20210403476A1 (en) 2021-12-30

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