JP7574206B2 - ステロール調節エレメント結合転写因子1(srebf1)阻害剤による上昇した脂質レベルの治療 - Google Patents
ステロール調節エレメント結合転写因子1(srebf1)阻害剤による上昇した脂質レベルの治療 Download PDFInfo
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- JP7574206B2 JP7574206B2 JP2021556508A JP2021556508A JP7574206B2 JP 7574206 B2 JP7574206 B2 JP 7574206B2 JP 2021556508 A JP2021556508 A JP 2021556508A JP 2021556508 A JP2021556508 A JP 2021556508A JP 7574206 B2 JP7574206 B2 JP 7574206B2
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N9/14—Hydrolases (3)
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
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- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Diabetes (AREA)
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- Hematology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962820893P | 2019-03-20 | 2019-03-20 | |
| US62/820,893 | 2019-03-20 | ||
| US201962879138P | 2019-07-26 | 2019-07-26 | |
| US62/879,138 | 2019-07-26 | ||
| PCT/US2020/023532 WO2020191141A1 (en) | 2019-03-20 | 2020-03-19 | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022525545A JP2022525545A (ja) | 2022-05-17 |
| JP2022525545A5 JP2022525545A5 (https=) | 2023-03-22 |
| JPWO2020191141A5 JPWO2020191141A5 (https=) | 2023-03-22 |
| JP7574206B2 true JP7574206B2 (ja) | 2024-10-28 |
Family
ID=70289471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556508A Active JP7574206B2 (ja) | 2019-03-20 | 2020-03-19 | ステロール調節エレメント結合転写因子1(srebf1)阻害剤による上昇した脂質レベルの治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11504390B2 (https=) |
| EP (1) | EP3942048A1 (https=) |
| JP (1) | JP7574206B2 (https=) |
| CN (2) | CN116889627A (https=) |
| CA (1) | CA3133000A1 (https=) |
| WO (1) | WO2020191141A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116583291A (zh) * | 2020-12-14 | 2023-08-11 | 雷杰纳荣制药公司 | 用抑制素亚基βE(INHBE)抑制剂治疗代谢病症和心血管疾病的方法 |
| MX2023007012A (es) | 2020-12-14 | 2023-06-27 | Regeneron Pharma | Metodos para tratar los trastornos metabolicos y las enfermedades cardiovasculares con inhibidores de la subunidad beta e de la inhibina (inhbe). |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013515085A (ja) | 2009-12-22 | 2013-05-02 | ジ・アドミニストレイターズ・オブ・ザ・チユレーン・エデユケーシヨナル・フアンド | 肥満症および糖尿病を治療するための組成物および方法 |
| CN109536610A (zh) | 2018-12-05 | 2019-03-29 | 西南大学 | Setdb1在调控胆固醇途径中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688787A (en) | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
| US5631356A (en) | 1992-04-03 | 1997-05-20 | Gist-Brocades, N.V. | Selective N-acylation of amino alcohols |
| LT3595B (en) | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| FR2710337B1 (fr) | 1993-09-23 | 1995-12-08 | Gerard Coquerel | Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé. |
| US5633246A (en) | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| US5756470A (en) | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6602710B1 (en) | 1998-08-27 | 2003-08-05 | Chugai Seiyaku Kabushiki Kaisha | Screening method for SREBP pathway-specific inhibitors |
| GB9916757D0 (en) | 1999-07-17 | 1999-09-15 | Glaxo Group Ltd | Method |
| HRP20030498A2 (en) | 2000-12-21 | 2005-04-30 | Aventis Pharma Deutschland Gmbh | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism |
| TWI291957B (en) | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
| US20080249040A1 (en) | 2001-05-18 | 2008-10-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA) |
| AU2002320621A1 (en) | 2001-07-20 | 2003-03-03 | Incyte Genomics, Inc. | Structural and cytoskeleton-associated proteins |
| WO2003033656A2 (en) * | 2001-10-16 | 2003-04-24 | Exelixis, Inc. | MSREBPs AS MODIFIERS OF THE SREBP PATHWAY AND METHODS OF USE |
| US20050014177A1 (en) | 2003-05-19 | 2005-01-20 | Koustubh Ranade | Human sterol response element binding protein 1 (SREBP1) single nucleotide polymorphisms |
| AU2007275365A1 (en) * | 2006-07-17 | 2008-01-24 | Sirna Therapeutics Inc. | RNA interference mediated inhibition of Proprotein Convertase Subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
| AU2007297388A1 (en) | 2006-09-18 | 2008-03-27 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of scap and therapeutic uses thereof |
| JP2010053122A (ja) * | 2008-07-31 | 2010-03-11 | Hayashibara Biochem Lab Inc | 脂質合成阻害剤 |
| US9187746B2 (en) | 2009-09-22 | 2015-11-17 | Alnylam Pharmaceuticals, Inc. | Dual targeting siRNA agents |
| WO2015100257A1 (en) | 2013-12-23 | 2015-07-02 | The General Hospital Corporation | Methods and assays for determining reduced brca1 pathway function in a cancer cell |
| WO2017100542A1 (en) | 2015-12-10 | 2017-06-15 | Alnylam Pharmaceuticals, Inc. | Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof |
| CN105441454B (zh) | 2015-12-23 | 2018-12-11 | 北京大学人民医院 | Scap基因突变体及其应用 |
| MX2018013499A (es) | 2016-05-03 | 2019-09-11 | Lonza Ag | Modulacion del metabolismo lipidico para la produccion de proteinas. |
| WO2019141723A1 (en) * | 2018-01-18 | 2019-07-25 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting srebp1 |
| AU2019212959A1 (en) | 2018-01-29 | 2020-09-17 | Capulus Therapeutics, Llc | SREBP inhibitors comprising a 6-membered central ring |
| US11648260B2 (en) | 2018-03-29 | 2023-05-16 | Technion Research And Development Foundation Limitted | Vesicles comprising a PTEN inhibitor and uses of same |
-
2020
- 2020-03-19 JP JP2021556508A patent/JP7574206B2/ja active Active
- 2020-03-19 CN CN202310867404.XA patent/CN116889627A/zh active Pending
- 2020-03-19 EP EP20719278.2A patent/EP3942048A1/en active Pending
- 2020-03-19 US US16/823,634 patent/US11504390B2/en active Active
- 2020-03-19 CN CN202080030927.3A patent/CN113727732B/zh active Active
- 2020-03-19 CA CA3133000A patent/CA3133000A1/en active Pending
- 2020-03-19 WO PCT/US2020/023532 patent/WO2020191141A1/en not_active Ceased
-
2022
- 2022-10-17 US US18/047,026 patent/US20230263821A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013515085A (ja) | 2009-12-22 | 2013-05-02 | ジ・アドミニストレイターズ・オブ・ザ・チユレーン・エデユケーシヨナル・フアンド | 肥満症および糖尿病を治療するための組成物および方法 |
| CN109536610A (zh) | 2018-12-05 | 2019-03-29 | 西南大学 | Setdb1在调控胆固醇途径中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3942048A1 (en) | 2022-01-26 |
| CN116889627A (zh) | 2023-10-17 |
| CN113727732A (zh) | 2021-11-30 |
| US20230263821A1 (en) | 2023-08-24 |
| US11504390B2 (en) | 2022-11-22 |
| US20200297752A1 (en) | 2020-09-24 |
| CA3133000A1 (en) | 2020-09-24 |
| JP2022525545A (ja) | 2022-05-17 |
| CN113727732B (zh) | 2023-08-08 |
| WO2020191141A1 (en) | 2020-09-24 |
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