CA3133000A1 - Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors - Google Patents

Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors Download PDF

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Publication number
CA3133000A1
CA3133000A1 CA3133000A CA3133000A CA3133000A1 CA 3133000 A1 CA3133000 A1 CA 3133000A1 CA 3133000 A CA3133000 A CA 3133000A CA 3133000 A CA3133000 A CA 3133000A CA 3133000 A1 CA3133000 A1 CA 3133000A1
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CA
Canada
Prior art keywords
seq
srebf1
nucleotide sequence
complement
position corresponding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3133000A
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English (en)
French (fr)
Inventor
Alan Shuldiner
Nehal GOSALIA
Cristopher Van Hout
Da-Wei Gong
James A. Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
University of Maryland Baltimore
Original Assignee
Regeneron Pharmaceuticals Inc
University of Maryland Baltimore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc, University of Maryland Baltimore filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3133000A1 publication Critical patent/CA3133000A1/en
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
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  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3133000A 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors Pending CA3133000A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962820893P 2019-03-20 2019-03-20
US62/820,893 2019-03-20
US201962879138P 2019-07-26 2019-07-26
US62/879,138 2019-07-26
PCT/US2020/023532 WO2020191141A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors

Publications (1)

Publication Number Publication Date
CA3133000A1 true CA3133000A1 (en) 2020-09-24

Family

ID=70289471

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3133000A Pending CA3133000A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors

Country Status (6)

Country Link
US (2) US11504390B2 (https=)
EP (1) EP3942048A1 (https=)
JP (1) JP7574206B2 (https=)
CN (2) CN116889627A (https=)
CA (1) CA3133000A1 (https=)
WO (1) WO2020191141A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116583291A (zh) * 2020-12-14 2023-08-11 雷杰纳荣制药公司 用抑制素亚基βE(INHBE)抑制剂治疗代谢病症和心血管疾病的方法
MX2023007012A (es) 2020-12-14 2023-06-27 Regeneron Pharma Metodos para tratar los trastornos metabolicos y las enfermedades cardiovasculares con inhibidores de la subunidad beta e de la inhibina (inhbe).

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Also Published As

Publication number Publication date
EP3942048A1 (en) 2022-01-26
CN116889627A (zh) 2023-10-17
JP7574206B2 (ja) 2024-10-28
CN113727732A (zh) 2021-11-30
US20230263821A1 (en) 2023-08-24
US11504390B2 (en) 2022-11-22
US20200297752A1 (en) 2020-09-24
JP2022525545A (ja) 2022-05-17
CN113727732B (zh) 2023-08-08
WO2020191141A1 (en) 2020-09-24

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