JP7566731B2 - Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 - Google Patents
Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 Download PDFInfo
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- JP7566731B2 JP7566731B2 JP2021522931A JP2021522931A JP7566731B2 JP 7566731 B2 JP7566731 B2 JP 7566731B2 JP 2021522931 A JP2021522931 A JP 2021522931A JP 2021522931 A JP2021522931 A JP 2021522931A JP 7566731 B2 JP7566731 B2 JP 7566731B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094148A JP2024116295A (ja) | 2018-07-03 | 2024-06-11 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693768P | 2018-07-03 | 2018-07-03 | |
| US62/693,768 | 2018-07-03 | ||
| US201962861825P | 2019-06-14 | 2019-06-14 | |
| US62/861,825 | 2019-06-14 | ||
| PCT/US2019/040317 WO2020010092A1 (en) | 2018-07-03 | 2019-07-02 | Compounds and compositions for treating conditions associated with sting activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094148A Division JP2024116295A (ja) | 2018-07-03 | 2024-06-11 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021529833A JP2021529833A (ja) | 2021-11-04 |
| JP2021529833A5 JP2021529833A5 (https=) | 2022-07-08 |
| JPWO2020010092A5 JPWO2020010092A5 (https=) | 2022-07-08 |
| JP7566731B2 true JP7566731B2 (ja) | 2024-10-15 |
Family
ID=67441650
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021522931A Active JP7566731B2 (ja) | 2018-07-03 | 2019-07-02 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| JP2024094148A Pending JP2024116295A (ja) | 2018-07-03 | 2024-06-11 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094148A Pending JP2024116295A (ja) | 2018-07-03 | 2024-06-11 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11618749B2 (https=) |
| EP (1) | EP3817820A1 (https=) |
| JP (2) | JP7566731B2 (https=) |
| CN (2) | CN112823036B (https=) |
| MA (1) | MA53095A (https=) |
| TW (1) | TWI873098B (https=) |
| WO (1) | WO2020010092A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024116295A (ja) * | 2018-07-03 | 2024-08-27 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7270608B2 (ja) | 2017-08-31 | 2023-05-10 | エフ－スター・セラピューティクス・インコーポレイテッド | 化合物、組成物、及び疾患の治療方法 |
| TW202043198A (zh) * | 2019-01-17 | 2020-12-01 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
| MA54753A (fr) * | 2019-01-17 | 2021-11-24 | Ifm Due Inc | Composés et compositions pour traiter des états pathologiques associés à une activité de sting |
| US20230092163A1 (en) * | 2019-06-14 | 2023-03-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN114761804A (zh) | 2019-06-21 | 2022-07-15 | 艾福姆德尤股份有限公司 | 治疗癌症的方法 |
| EP4085061A1 (en) * | 2019-12-31 | 2022-11-09 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2021161230A1 (en) * | 2020-02-12 | 2021-08-19 | Curadev Pharma Pvt. Ltd. | Small molecule sting antagonists |
| JP6912016B1 (ja) * | 2020-04-10 | 2021-07-28 | 小野薬品工業株式会社 | Ｓｔｉｎｇ作動化合物 |
| EP4134134A4 (en) * | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONISTIC COMPOUND |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| EP4247790B1 (en) * | 2020-11-23 | 2024-10-09 | Regor Pharmaceuticals, Inc. | Sting antagonists and uses thereof |
| WO2022140397A1 (en) | 2020-12-22 | 2022-06-30 | Ifm Due, Inc. | Methods of treating cancer |
| US20240060982A1 (en) | 2020-12-22 | 2024-02-22 | Ifm Due, Inc. | Methods of treating cancer |
| EP4267129A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4267128A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4274826A1 (en) * | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Oxalamide compounds and compositions for treating conditions associated with sting activity |
| JP2024502470A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| TW202235073A (zh) | 2021-01-08 | 2022-09-16 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關的病狀之化合物及組合物 |
| US20240101556A1 (en) | 2021-01-08 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US11964978B2 (en) * | 2021-03-18 | 2024-04-23 | Pfizer Inc. | Modulators of STING (stimulator of interferon genes) |
| US12065427B2 (en) | 2021-04-29 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating STING |
| UY39892A (es) | 2021-08-10 | 2023-03-31 | Novartis Pharma Ag | Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING |
| AU2022325543A1 (en) * | 2021-08-11 | 2024-02-15 | Curadev Pharma Pvt. Ltd. | Small molecule sting antagonists |
| CN115710255B (zh) * | 2021-08-23 | 2025-05-06 | 上海交通大学 | 一类含有苯并杂环取代的脲类衍生物及其制备和用途 |
| CN116789641A (zh) * | 2022-03-17 | 2023-09-22 | 中国科学院上海药物研究所 | 二氢异喹啉类化合物及其医药用途 |
| WO2024032597A1 (zh) * | 2022-08-11 | 2024-02-15 | 杭州中美华东制药有限公司 | 具有sting抑制作用的酰胺类化合物及其药物组合物和用途 |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
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| TW202432114A (zh) * | 2022-10-26 | 2024-08-16 | 德商百靈佳殷格翰國際股份有限公司 | 可活化sting之雜環化合物 |
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| CN120476113A (zh) * | 2022-12-20 | 2025-08-12 | 杭州中美华东制药有限公司 | 具有sting抑制作用的含肟化合物及其药物组合物和用途 |
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| CN121342824A (zh) * | 2024-07-16 | 2026-01-16 | 中国药科大学 | 四氢萘啶类sting抑制剂及其医药用途 |
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| WO2021067805A1 (en) | 2019-10-03 | 2021-04-08 | Ifm Due, Inc. | Oxalamide heterobycyclic compounds and compositions for treating conditions associated with sting activity |
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| EP4085061A1 (en) | 2019-12-31 | 2022-11-09 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| JP7756643B2 (ja) | 2019-12-31 | 2025-10-20 | ノバルティス ファーマ アーゲー | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US20220024919A1 (en) | 2020-07-15 | 2022-01-27 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| PY2157405A (es) | 2020-07-15 | 2022-04-22 | Ifm Due Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad del sting |
| WO2022015938A1 (en) | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP4182310A1 (en) | 2020-07-15 | 2023-05-24 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20220024906A1 (en) | 2020-07-15 | 2022-01-27 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20230250106A1 (en) | 2020-07-15 | 2023-08-10 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP4182030A1 (en) | 2020-07-15 | 2023-05-24 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
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2019
- 2019-07-02 CN CN201980057319.9A patent/CN112823036B/zh active Active
- 2019-07-02 JP JP2021522931A patent/JP7566731B2/ja active Active
- 2019-07-02 TW TW108123334A patent/TWI873098B/zh active
- 2019-07-02 WO PCT/US2019/040317 patent/WO2020010092A1/en not_active Ceased
- 2019-07-02 US US16/460,381 patent/US11618749B2/en active Active
- 2019-07-02 EP EP19745408.5A patent/EP3817820A1/en active Pending
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2023
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| WO2003028724A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| JP2015098482A (ja) | 2008-05-13 | 2015-05-28 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害剤としてのピロロピリジン |
| JP2020524718A (ja) | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | ヒトｓｔｉｎｇの複素環式小分子調節因子 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024116295A (ja) * | 2018-07-03 | 2024-08-27 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI873098B (zh) | 2025-02-21 |
| WO2020010092A1 (en) | 2020-01-09 |
| CN120004785A (zh) | 2025-05-16 |
| CN112823036A (zh) | 2021-05-18 |
| EP3817820A1 (en) | 2021-05-12 |
| US11618749B2 (en) | 2023-04-04 |
| JP2024116295A (ja) | 2024-08-27 |
| TW202014408A (zh) | 2020-04-16 |
| MA53095A (fr) | 2021-05-12 |
| JP2021529833A (ja) | 2021-11-04 |
| US20200172534A1 (en) | 2020-06-04 |
| CN112823036B (zh) | 2024-11-08 |
| US20240083895A1 (en) | 2024-03-14 |
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