JP7555542B2 - 統合失調症及び他の神経精神障害の治療方法 - Google Patents
統合失調症及び他の神経精神障害の治療方法 Download PDFInfo
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- JP7555542B2 JP7555542B2 JP2020570726A JP2020570726A JP7555542B2 JP 7555542 B2 JP7555542 B2 JP 7555542B2 JP 2020570726 A JP2020570726 A JP 2020570726A JP 2020570726 A JP2020570726 A JP 2020570726A JP 7555542 B2 JP7555542 B2 JP 7555542B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
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- Psychiatry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
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- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024043444A JP2024075673A (ja) | 2018-06-18 | 2024-03-19 | 統合失調症及び他の神経精神障害の治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862686346P | 2018-06-18 | 2018-06-18 | |
| US62/686,346 | 2018-06-18 | ||
| PCT/US2019/037754 WO2019246112A1 (en) | 2018-06-18 | 2019-06-18 | Methods of treating schizophrenia and other neuropsychiatric disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024043444A Division JP2024075673A (ja) | 2018-06-18 | 2024-03-19 | 統合失調症及び他の神経精神障害の治療方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021529169A JP2021529169A (ja) | 2021-10-28 |
| JPWO2019246112A5 JPWO2019246112A5 (https=) | 2022-05-19 |
| JP2021529169A5 JP2021529169A5 (https=) | 2022-05-19 |
| JP7555542B2 true JP7555542B2 (ja) | 2024-09-25 |
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ID=67297259
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570726A Active JP7555542B2 (ja) | 2018-06-18 | 2019-06-18 | 統合失調症及び他の神経精神障害の治療方法 |
| JP2024043444A Pending JP2024075673A (ja) | 2018-06-18 | 2024-03-19 | 統合失調症及び他の神経精神障害の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024043444A Pending JP2024075673A (ja) | 2018-06-18 | 2024-03-19 | 統合失調症及び他の神経精神障害の治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210260002A1 (https=) |
| EP (1) | EP3806861A1 (https=) |
| JP (2) | JP7555542B2 (https=) |
| KR (1) | KR102847197B1 (https=) |
| CN (1) | CN112566640A (https=) |
| CA (1) | CA3103663A1 (https=) |
| WO (1) | WO2019246112A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110011658A (ko) | 2008-05-08 | 2011-02-08 | 유니버시티 오브 로체스터 | 최적화된 세포 제제에 의한 수초 질환의 치료 |
| EP2954046B1 (en) | 2013-02-06 | 2025-10-15 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| JP7457505B2 (ja) | 2017-05-10 | 2024-03-28 | ユニバーシティー オブ ロチェスター | 神経精神障害を処置する方法 |
| WO2019246262A2 (en) | 2018-06-21 | 2019-12-26 | University Of Rochester | Methods of treating or inhibiting onset of huntington's disease |
| CN120754249A (zh) * | 2021-09-30 | 2025-10-10 | 上海鲸奇生物科技有限公司 | 直接转分化治疗神经系统疾病 |
| WO2024181416A1 (ja) * | 2023-02-28 | 2024-09-06 | 国立大学法人大阪大学 | オリゴヌクレオチド、ならびにそれを用いるrest発現抑制剤および医薬組成物 |
| WO2025184089A1 (en) * | 2024-02-29 | 2025-09-04 | Board Of Regents, The University Of Texas System | Compositions and methods of use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935811A (en) | 1995-03-03 | 1999-08-10 | California Institute Of Technology | Neuron-restrictive silencer factor nucleic acids |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6838283B2 (en) | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
| CZ296576B6 (cs) | 1999-02-12 | 2006-04-12 | Sankyo Company Limited | Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem |
| US7098192B2 (en) | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
| US7179796B2 (en) | 2000-01-18 | 2007-02-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| US20030027153A1 (en) * | 2001-01-09 | 2003-02-06 | Meyer Joanne M. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
| JP2005504020A (ja) | 2001-07-03 | 2005-02-10 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヌクレアーゼ耐性キメラオリゴヌクレオチド |
| AU2003260370B2 (en) | 2002-08-05 | 2008-05-22 | Silence Therapeutics Gmbh | Further novel forms of interfering RNA molecules |
| EP1393776A1 (en) * | 2002-08-14 | 2004-03-03 | Erasmus University Medical Center Rotterdam | Use of genes identified to be involved in tumor development for the development of anti-cancer drugs and diagnosis of cancer |
| KR100750788B1 (ko) | 2003-09-18 | 2007-08-20 | 아이시스 파마수티컬즈 인코포레이티드 | eIF4E 발현의 조정 |
| AU2005252663B2 (en) | 2004-06-03 | 2011-07-07 | Isis Pharmaceuticals, Inc. | Double strand compositions comprising differentially modified strands for use in gene modulation |
| JP4428296B2 (ja) | 2005-06-10 | 2010-03-10 | セイコーエプソン株式会社 | 表示パネルモジュールおよび表示装置 |
| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| WO2009027349A2 (en) | 2007-08-24 | 2009-03-05 | Oryzon Genomics Sa | Treatment and prevention of neurodegenerative diseases |
| US10047346B2 (en) | 2008-08-08 | 2018-08-14 | Mayo Foundation For Medical Education And Research | Method of treating heart tissue using induced pluripotent stem cells |
| WO2011031998A1 (en) * | 2009-09-11 | 2011-03-17 | Isis Pharmaceuticals, Inc. | Modulation of re1 silencing transcription factor expression |
| US20120276070A1 (en) | 2009-11-17 | 2012-11-01 | Vitro Diagnositics, Inc. | Induced Pluripotent Stem Cells and Related Methods |
| US9005967B2 (en) | 2010-01-22 | 2015-04-14 | Kyoto University | Myc variants improve induced pluripotent stem cell generation efficiency |
| KR101235256B1 (ko) * | 2010-09-13 | 2013-02-21 | 서울대학교산학협력단 | miRNA를 타겟으로 한 신경퇴행성 질환 치료 |
-
2019
- 2019-06-18 CN CN201980053363.2A patent/CN112566640A/zh active Pending
- 2019-06-18 US US17/254,008 patent/US20210260002A1/en active Pending
- 2019-06-18 WO PCT/US2019/037754 patent/WO2019246112A1/en not_active Ceased
- 2019-06-18 KR KR1020217001589A patent/KR102847197B1/ko active Active
- 2019-06-18 EP EP19740110.2A patent/EP3806861A1/en active Pending
- 2019-06-18 JP JP2020570726A patent/JP7555542B2/ja active Active
- 2019-06-18 CA CA3103663A patent/CA3103663A1/en active Pending
-
2024
- 2024-03-19 JP JP2024043444A patent/JP2024075673A/ja active Pending
Non-Patent Citations (3)
| Title |
|---|
| Mol. Neurobiol.,2017年,Vol.54,pp.541-550,DOI 10.1007/s12035-015-9658-4 |
| Pharmacol. Rev.,2013年,Vol.65,pp.105-142,http://dx.doi.org/10.1124/pr.111.005512 |
| STEM CELLS,2013年,Vol.31,pp.1816-1828 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112566640A (zh) | 2021-03-26 |
| WO2019246112A1 (en) | 2019-12-26 |
| EP3806861A1 (en) | 2021-04-21 |
| US20210260002A1 (en) | 2021-08-26 |
| JP2024075673A (ja) | 2024-06-04 |
| CA3103663A1 (en) | 2019-12-26 |
| KR102847197B1 (ko) | 2025-08-20 |
| KR20210056324A (ko) | 2021-05-18 |
| JP2021529169A (ja) | 2021-10-28 |
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