JP2021529169A5 - - Google Patents

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Publication number
JP2021529169A5
JP2021529169A5 JP2020570726A JP2020570726A JP2021529169A5 JP 2021529169 A5 JP2021529169 A5 JP 2021529169A5 JP 2020570726 A JP2020570726 A JP 2020570726A JP 2020570726 A JP2020570726 A JP 2020570726A JP 2021529169 A5 JP2021529169 A5 JP 2021529169A5
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JP
Japan
Prior art keywords
therapeutic composition
composition according
rest
inhibitor
subject
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JP2020570726A
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English (en)
Japanese (ja)
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JPWO2019246112A5 (https=
JP7555542B2 (ja
JP2021529169A (ja
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Priority claimed from PCT/US2019/037754 external-priority patent/WO2019246112A1/en
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Publication of JPWO2019246112A5 publication Critical patent/JPWO2019246112A5/ja
Publication of JP2021529169A5 publication Critical patent/JP2021529169A5/ja
Priority to JP2024043444A priority Critical patent/JP2024075673A/ja
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JP2020570726A 2018-06-18 2019-06-18 統合失調症及び他の神経精神障害の治療方法 Active JP7555542B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024043444A JP2024075673A (ja) 2018-06-18 2024-03-19 統合失調症及び他の神経精神障害の治療方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862686346P 2018-06-18 2018-06-18
US62/686,346 2018-06-18
PCT/US2019/037754 WO2019246112A1 (en) 2018-06-18 2019-06-18 Methods of treating schizophrenia and other neuropsychiatric disorders

Related Child Applications (1)

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JP2024043444A Division JP2024075673A (ja) 2018-06-18 2024-03-19 統合失調症及び他の神経精神障害の治療方法

Publications (4)

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JP2021529169A JP2021529169A (ja) 2021-10-28
JPWO2019246112A5 JPWO2019246112A5 (https=) 2022-05-19
JP2021529169A5 true JP2021529169A5 (https=) 2022-05-19
JP7555542B2 JP7555542B2 (ja) 2024-09-25

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JP2020570726A Active JP7555542B2 (ja) 2018-06-18 2019-06-18 統合失調症及び他の神経精神障害の治療方法
JP2024043444A Pending JP2024075673A (ja) 2018-06-18 2024-03-19 統合失調症及び他の神経精神障害の治療方法

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Country Status (7)

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US (1) US20210260002A1 (https=)
EP (1) EP3806861A1 (https=)
JP (2) JP7555542B2 (https=)
KR (1) KR102847197B1 (https=)
CN (1) CN112566640A (https=)
CA (1) CA3103663A1 (https=)
WO (1) WO2019246112A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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KR20110011658A (ko) 2008-05-08 2011-02-08 유니버시티 오브 로체스터 최적화된 세포 제제에 의한 수초 질환의 치료
EP2954046B1 (en) 2013-02-06 2025-10-15 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法
WO2019246262A2 (en) 2018-06-21 2019-12-26 University Of Rochester Methods of treating or inhibiting onset of huntington's disease
CN120754249A (zh) * 2021-09-30 2025-10-10 上海鲸奇生物科技有限公司 直接转分化治疗神经系统疾病
WO2024181416A1 (ja) * 2023-02-28 2024-09-06 国立大学法人大阪大学 オリゴヌクレオチド、ならびにそれを用いるrest発現抑制剤および医薬組成物
WO2025184089A1 (en) * 2024-02-29 2025-09-04 Board Of Regents, The University Of Texas System Compositions and methods of use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935811A (en) 1995-03-03 1999-08-10 California Institute Of Technology Neuron-restrictive silencer factor nucleic acids
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6838283B2 (en) 1998-09-29 2005-01-04 Isis Pharmaceuticals Inc. Antisense modulation of survivin expression
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
US7179796B2 (en) 2000-01-18 2007-02-20 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
WO2003070918A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Rna interference by modified short interfering nucleic acid
US20030027153A1 (en) * 2001-01-09 2003-02-06 Meyer Joanne M. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
JP2005504020A (ja) 2001-07-03 2005-02-10 アイシス・ファーマシューティカルス・インコーポレーテッド ヌクレアーゼ耐性キメラオリゴヌクレオチド
AU2003260370B2 (en) 2002-08-05 2008-05-22 Silence Therapeutics Gmbh Further novel forms of interfering RNA molecules
EP1393776A1 (en) * 2002-08-14 2004-03-03 Erasmus University Medical Center Rotterdam Use of genes identified to be involved in tumor development for the development of anti-cancer drugs and diagnosis of cancer
KR100750788B1 (ko) 2003-09-18 2007-08-20 아이시스 파마수티컬즈 인코포레이티드 eIF4E 발현의 조정
AU2005252663B2 (en) 2004-06-03 2011-07-07 Isis Pharmaceuticals, Inc. Double strand compositions comprising differentially modified strands for use in gene modulation
JP4428296B2 (ja) 2005-06-10 2010-03-10 セイコーエプソン株式会社 表示パネルモジュールおよび表示装置
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
DK3399025T3 (da) 2007-03-23 2025-06-16 Wisconsin Alumni Res Found Omprogrammering af somatiske celler
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2009027349A2 (en) 2007-08-24 2009-03-05 Oryzon Genomics Sa Treatment and prevention of neurodegenerative diseases
US10047346B2 (en) 2008-08-08 2018-08-14 Mayo Foundation For Medical Education And Research Method of treating heart tissue using induced pluripotent stem cells
WO2011031998A1 (en) * 2009-09-11 2011-03-17 Isis Pharmaceuticals, Inc. Modulation of re1 silencing transcription factor expression
US20120276070A1 (en) 2009-11-17 2012-11-01 Vitro Diagnositics, Inc. Induced Pluripotent Stem Cells and Related Methods
US9005967B2 (en) 2010-01-22 2015-04-14 Kyoto University Myc variants improve induced pluripotent stem cell generation efficiency
KR101235256B1 (ko) * 2010-09-13 2013-02-21 서울대학교산학협력단 miRNA를 타겟으로 한 신경퇴행성 질환 치료

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