JP7545210B2 - アデノ随伴ウイルス製剤 - Google Patents
アデノ随伴ウイルス製剤 Download PDFInfo
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- JP7545210B2 JP7545210B2 JP2019522442A JP2019522442A JP7545210B2 JP 7545210 B2 JP7545210 B2 JP 7545210B2 JP 2019522442 A JP2019522442 A JP 2019522442A JP 2019522442 A JP2019522442 A JP 2019522442A JP 7545210 B2 JP7545210 B2 JP 7545210B2
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- pharmaceutical composition
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- sodium chloride
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- 235000002639 sodium chloride Nutrition 0.000 claims description 307
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 301
- 239000008194 pharmaceutical composition Substances 0.000 claims description 288
- 239000011780 sodium chloride Substances 0.000 claims description 151
- 150000003839 salts Chemical class 0.000 claims description 150
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-Histidine Natural products OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 142
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 141
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 128
- 238000000034 method Methods 0.000 claims description 86
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 77
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 77
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 39
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- 241001164825 Adeno-associated virus - 8 Species 0.000 claims description 23
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
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- 239000001509 sodium citrate Substances 0.000 claims description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
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- DPVHGFAJLZWDOC-PVXXTIHASA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate Chemical group O.O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DPVHGFAJLZWDOC-PVXXTIHASA-N 0.000 claims description 5
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- 241000649045 Adeno-associated virus 10 Species 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
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- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 229940074409 trehalose dihydrate Drugs 0.000 claims description 5
- 229920002307 Dextran Polymers 0.000 claims description 4
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 claims description 3
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- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 4
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| BR112019009113A2 (pt) | 2016-11-04 | 2019-07-16 | Baxalta Incorporated | formulações de vírus adenoassociado |
| JP2021505610A (ja) * | 2017-12-05 | 2021-02-18 | アプライド ジェネティック テクノロジーズ コーポレイション | ウイルス粒子のための製剤最適化 |
| TW202016314A (zh) | 2018-05-09 | 2020-05-01 | 美商拜奧馬林製藥公司 | 治療苯丙酮尿症之方法 |
| TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
| KR20210032984A (ko) * | 2018-07-11 | 2021-03-25 | 박스알타 인코퍼레이티드 | Aav 조성물 |
| CN112770812A (zh) * | 2018-07-24 | 2021-05-07 | 沃雅戈治疗公司 | 产生基因治疗制剂的系统和方法 |
| SG11202107645RA (en) * | 2019-01-18 | 2021-08-30 | Voyager Therapeutics Inc | Methods and systems for producing aav particles |
| TW202332458A (zh) * | 2019-04-19 | 2023-08-16 | 美商銳進科斯生物股份有限公司 | 腺相關病毒載體調配物及方法 |
| WO2021071835A1 (en) * | 2019-10-07 | 2021-04-15 | Regenxbio Inc. | Adeno-associated virus vector pharmaceutical composition and methods |
| TW202144575A (zh) * | 2020-04-03 | 2021-12-01 | 美商拜奧馬林製藥公司 | 使用ａａｖ及治療調配物之苯酮尿症治療 |
| CN114903922B (zh) * | 2021-02-09 | 2024-04-26 | 武汉博沃生物科技有限公司 | 包含腺病毒的医药配制品及其保存方法 |
| US20240307553A1 (en) * | 2021-04-01 | 2024-09-19 | Pfizer Inc. | Pharmaceutical compositions containing adeno-associated viral vector |
| CN117836010A (zh) * | 2021-06-21 | 2024-04-05 | 优尼科生物制药有限公司 | 改进的裂解程序 |
| CR20240004A (es) * | 2021-07-08 | 2024-06-11 | Biocad Joint Stock Co | Composición farmacéutica de virus no encapsulado |
| CN117980471A (zh) | 2021-08-04 | 2024-05-03 | 武田药品工业株式会社 | 阳离子交换剂上的腺相关病毒分离 |
| US20230090654A1 (en) * | 2021-08-24 | 2023-03-23 | Homology Medicines, Inc. | Adeno-associated virus formulations |
| CN114949198B (zh) * | 2022-06-02 | 2026-03-31 | 金宇保灵生物药品有限公司 | 一种禽类动物疫苗用油包水佐剂及其制备方法和应用 |
| WO2023236964A1 (zh) * | 2022-06-07 | 2023-12-14 | 成都弘基生物科技有限公司 | 腺相关病毒药物组合物及其用途 |
| CN115337408A (zh) * | 2022-09-16 | 2022-11-15 | 上海信致医药科技有限公司 | 腺相关病毒制剂 |
| JP2025533988A (ja) * | 2022-10-11 | 2025-10-09 | メイラグティーエックス ユーケー アイアイ リミティド | Ａａｖ遺伝子療法用の製剤 |
| TW202426017A (zh) * | 2022-11-24 | 2024-07-01 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 非包膜病毒的藥物組合物 |
| WO2024138129A2 (en) * | 2022-12-23 | 2024-06-27 | Spark Therapeutics, Inc. | Adeno-associated virus formulations |
| CN120000811A (zh) * | 2023-11-15 | 2025-05-16 | 成都弘基生物科技有限公司 | 一种重组腺相关病毒药物组合物及其用途 |
| WO2025114524A1 (en) * | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
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| JP2003525909A (ja) | 2000-03-07 | 2003-09-02 | メルク エンド カムパニー インコーポレーテッド | アデノウイルス製剤 |
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| JP2019537578A (ja) | 2019-12-26 |
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| EP4360652A2 (en) | 2024-05-01 |
| RU2019116442A3 (https=) | 2021-06-21 |
| MX2019005088A (es) | 2019-08-12 |
| US20190255126A1 (en) | 2019-08-22 |
| IL266264A (en) | 2019-06-30 |
| JP2022137241A (ja) | 2022-09-21 |
| KR102574849B1 (ko) | 2023-09-06 |
| CA3042689A1 (en) | 2018-07-12 |
| ES2981519T3 (es) | 2024-10-09 |
| EP3534922A1 (en) | 2019-09-11 |
| IL266264B1 (en) | 2023-07-01 |
| US20230241139A1 (en) | 2023-08-03 |
| IL266264B2 (en) | 2023-11-01 |
| AU2017391165B2 (en) | 2023-02-02 |
| BR112019009113A2 (pt) | 2019-07-16 |
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