JP7522732B2 - 眼疾患治療用のペプチド及び医薬組成物 - Google Patents
眼疾患治療用のペプチド及び医薬組成物 Download PDFInfo
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- JP7522732B2 JP7522732B2 JP2021526304A JP2021526304A JP7522732B2 JP 7522732 B2 JP7522732 B2 JP 7522732B2 JP 2021526304 A JP2021526304 A JP 2021526304A JP 2021526304 A JP2021526304 A JP 2021526304A JP 7522732 B2 JP7522732 B2 JP 7522732B2
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- 238000011191 terminal modification Methods 0.000 description 1
- VULKFBHOEKTQSF-UHFFFAOYSA-N tert-butyl n-[2-(2-aminoethoxy)ethyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCOCCN VULKFBHOEKTQSF-UHFFFAOYSA-N 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 125000005306 thianaphthenyl group Chemical group 0.000 description 1
- 125000004627 thianthrenyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3SC12)* 0.000 description 1
- 125000005302 thiazolylmethyl group Chemical group [H]C1=C([H])N=C(S1)C([H])([H])* 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
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- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862767180P | 2018-11-14 | 2018-11-14 | |
| US62/767,180 | 2018-11-14 | ||
| PCT/IB2019/001220 WO2020099925A2 (en) | 2018-11-14 | 2019-11-14 | Peptides and pharmaceutical compositions for treating eye diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022507404A JP2022507404A (ja) | 2022-01-18 |
| JP2022507404A5 JP2022507404A5 (https=) | 2022-11-22 |
| JP7522732B2 true JP7522732B2 (ja) | 2024-07-25 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| JP2021526304A Active JP7522732B2 (ja) | 2018-11-14 | 2019-11-14 | 眼疾患治療用のペプチド及び医薬組成物 |
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| Country | Link |
|---|---|
| EP (1) | EP3880690A4 (https=) |
| JP (1) | JP7522732B2 (https=) |
| KR (1) | KR20210087539A (https=) |
| CN (1) | CN113474356B (https=) |
| AU (1) | AU2019378162B2 (https=) |
| BR (1) | BR112021009341A2 (https=) |
| MX (1) | MX2021005077A (https=) |
| SG (1) | SG11202104178TA (https=) |
| TW (1) | TWI865470B (https=) |
| WO (1) | WO2020099925A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2766160C2 (ru) | 2017-05-17 | 2022-02-08 | Юю Фарма, Инк. | Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента |
| US11613558B2 (en) | 2018-11-14 | 2023-03-28 | Yuyu Pharma, Inc. | Peptides and pharmaceutical compositions for treating eye diseases |
| BR112021023477A2 (pt) | 2019-05-21 | 2022-02-15 | Eyebio Korea | Novo composto peptídico, composição farmacêutica para prevenir ou tratar inflamação, composição de alimento para prevenir ou amenizar a inflamação e composição de cosmético tendo um efeito anti inflamatório |
| CA3170606A1 (en) * | 2020-03-05 | 2021-09-30 | Wonsang YU | Treatment of inflammatory diseases with peptides and pharmaceutical compositions |
| EP4450079A4 (en) * | 2021-12-13 | 2025-12-10 | Eyebiokorea Inc | COMPOSITION FOR THE TREATMENT OF MACULAR DEGENERATION COMPRISING A NEW PEPTIDE |
| KR102662922B1 (ko) * | 2022-05-31 | 2024-05-03 | 주식회사 세네릭스 | 신규의 d-아미노산 유도체 및 이를 포함하는 약학 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017175963A1 (ko) | 2016-04-08 | 2017-10-12 | 주식회사 아이바이오코리아 | 연골세포 세포외기질 유래 펩타이드 |
| JP2020520372A (ja) | 2017-05-17 | 2020-07-09 | ユーユー ファーマ，インコーポレーテッド | 新規ペプチド及びその新規ペプチドを活性成分として含む眼疾患の治療のための医薬組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037135A (en) * | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| KR101690539B1 (ko) * | 2015-07-30 | 2016-12-29 | 주식회사 아이바이오코리아 | 건성안 예방 또는 치료용 약학조성물 |
| KR101795653B1 (ko) * | 2016-05-19 | 2017-11-09 | 인제대학교 산학협력단 | 콜라겐 타입 ii 펩타이드-아플리버셉트의 키메라 단백질을 유효성분으로 함유하는 혈관신생 억제용 조성물 |
| KR20180074928A (ko) * | 2016-12-26 | 2018-07-04 | 주식회사 아이바이오코리아 | 건성안 예방 또는 치료용 동물 의약품 조성물 |
-
2019
- 2019-11-13 TW TW108141290A patent/TWI865470B/zh active
- 2019-11-14 JP JP2021526304A patent/JP7522732B2/ja active Active
- 2019-11-14 SG SG11202104178TA patent/SG11202104178TA/en unknown
- 2019-11-14 CN CN201980078779.XA patent/CN113474356B/zh active Active
- 2019-11-14 WO PCT/IB2019/001220 patent/WO2020099925A2/en not_active Ceased
- 2019-11-14 EP EP19883897.1A patent/EP3880690A4/en active Pending
- 2019-11-14 AU AU2019378162A patent/AU2019378162B2/en active Active
- 2019-11-14 MX MX2021005077A patent/MX2021005077A/es unknown
- 2019-11-14 BR BR112021009341-9A patent/BR112021009341A2/pt unknown
- 2019-11-14 KR KR1020217018226A patent/KR20210087539A/ko not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017175963A1 (ko) | 2016-04-08 | 2017-10-12 | 주식회사 아이바이오코리아 | 연골세포 세포외기질 유래 펩타이드 |
| JP2020520372A (ja) | 2017-05-17 | 2020-07-09 | ユーユー ファーマ，インコーポレーテッド | 新規ペプチド及びその新規ペプチドを活性成分として含む眼疾患の治療のための医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020099925A3 (en) | 2020-06-25 |
| WO2020099925A2 (en) | 2020-05-22 |
| CN113474356B (zh) | 2024-12-17 |
| SG11202104178TA (en) | 2021-05-28 |
| AU2019378162B2 (en) | 2025-01-30 |
| JP2022507404A (ja) | 2022-01-18 |
| EP3880690A4 (en) | 2023-09-13 |
| EP3880690A2 (en) | 2021-09-22 |
| CA3119921A1 (en) | 2020-05-22 |
| CN113474356A (zh) | 2021-10-01 |
| MX2021005077A (es) | 2021-08-11 |
| KR20210087539A (ko) | 2021-07-12 |
| AU2019378162A1 (en) | 2021-05-20 |
| TW202031675A (zh) | 2020-09-01 |
| TWI865470B (zh) | 2024-12-11 |
| BR112021009341A2 (pt) | 2021-08-10 |
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