TWI865470B - 治療眼睛疾病之肽及醫藥組合物 - Google Patents
治療眼睛疾病之肽及醫藥組合物 Download PDFInfo
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- TWI865470B TWI865470B TW108141290A TW108141290A TWI865470B TW I865470 B TWI865470 B TW I865470B TW 108141290 A TW108141290 A TW 108141290A TW 108141290 A TW108141290 A TW 108141290A TW I865470 B TWI865470 B TW I865470B
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- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- OWTGMPPCCUSXIP-FNXFGIETSA-J tetrasodium;[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O OWTGMPPCCUSXIP-FNXFGIETSA-J 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 125000005306 thianaphthenyl group Chemical group 0.000 description 1
- 125000005302 thiazolylmethyl group Chemical group [H]C1=C([H])N=C(S1)C([H])([H])* 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Chemical group 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862767180P | 2018-11-14 | 2018-11-14 | |
| US62/767,180 | 2018-11-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202031675A TW202031675A (zh) | 2020-09-01 |
| TWI865470B true TWI865470B (zh) | 2024-12-11 |
Family
ID=70732068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108141290A TWI865470B (zh) | 2018-11-14 | 2019-11-13 | 治療眼睛疾病之肽及醫藥組合物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3880690A4 (https=) |
| JP (1) | JP7522732B2 (https=) |
| KR (1) | KR20210087539A (https=) |
| CN (1) | CN113474356B (https=) |
| AU (1) | AU2019378162B2 (https=) |
| BR (1) | BR112021009341A2 (https=) |
| MX (1) | MX2021005077A (https=) |
| SG (1) | SG11202104178TA (https=) |
| TW (1) | TWI865470B (https=) |
| WO (1) | WO2020099925A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2766160C2 (ru) | 2017-05-17 | 2022-02-08 | Юю Фарма, Инк. | Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента |
| US11613558B2 (en) | 2018-11-14 | 2023-03-28 | Yuyu Pharma, Inc. | Peptides and pharmaceutical compositions for treating eye diseases |
| BR112021023477A2 (pt) | 2019-05-21 | 2022-02-15 | Eyebio Korea | Novo composto peptídico, composição farmacêutica para prevenir ou tratar inflamação, composição de alimento para prevenir ou amenizar a inflamação e composição de cosmético tendo um efeito anti inflamatório |
| CA3170606A1 (en) * | 2020-03-05 | 2021-09-30 | Wonsang YU | Treatment of inflammatory diseases with peptides and pharmaceutical compositions |
| EP4450079A4 (en) * | 2021-12-13 | 2025-12-10 | Eyebiokorea Inc | COMPOSITION FOR THE TREATMENT OF MACULAR DEGENERATION COMPRISING A NEW PEPTIDE |
| KR102662922B1 (ko) * | 2022-05-31 | 2024-05-03 | 주식회사 세네릭스 | 신규의 d-아미노산 유도체 및 이를 포함하는 약학 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037135A (en) * | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| KR101690539B1 (ko) * | 2015-07-30 | 2016-12-29 | 주식회사 아이바이오코리아 | 건성안 예방 또는 치료용 약학조성물 |
| EP3539559B1 (en) * | 2016-04-08 | 2020-08-26 | Eyebio Korea | Collagen type ii alpha-1-based peptide for use in the treatment of macular degeneration |
| KR101795653B1 (ko) * | 2016-05-19 | 2017-11-09 | 인제대학교 산학협력단 | 콜라겐 타입 ii 펩타이드-아플리버셉트의 키메라 단백질을 유효성분으로 함유하는 혈관신생 억제용 조성물 |
| KR20180074928A (ko) * | 2016-12-26 | 2018-07-04 | 주식회사 아이바이오코리아 | 건성안 예방 또는 치료용 동물 의약품 조성물 |
| RU2766160C2 (ru) * | 2017-05-17 | 2022-02-08 | Юю Фарма, Инк. | Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента |
-
2019
- 2019-11-13 TW TW108141290A patent/TWI865470B/zh active
- 2019-11-14 JP JP2021526304A patent/JP7522732B2/ja active Active
- 2019-11-14 SG SG11202104178TA patent/SG11202104178TA/en unknown
- 2019-11-14 CN CN201980078779.XA patent/CN113474356B/zh active Active
- 2019-11-14 WO PCT/IB2019/001220 patent/WO2020099925A2/en not_active Ceased
- 2019-11-14 EP EP19883897.1A patent/EP3880690A4/en active Pending
- 2019-11-14 AU AU2019378162A patent/AU2019378162B2/en active Active
- 2019-11-14 MX MX2021005077A patent/MX2021005077A/es unknown
- 2019-11-14 BR BR112021009341-9A patent/BR112021009341A2/pt unknown
- 2019-11-14 KR KR1020217018226A patent/KR20210087539A/ko not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Lee et al., "Anti-inflammatory effect of hydroxyproline-GQDGLAGPK in desiccation stress-induced experimental dry eye mouse", Scientific Reports, 2017, 7, no.7413. |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020099925A3 (en) | 2020-06-25 |
| WO2020099925A2 (en) | 2020-05-22 |
| JP7522732B2 (ja) | 2024-07-25 |
| CN113474356B (zh) | 2024-12-17 |
| SG11202104178TA (en) | 2021-05-28 |
| AU2019378162B2 (en) | 2025-01-30 |
| JP2022507404A (ja) | 2022-01-18 |
| EP3880690A4 (en) | 2023-09-13 |
| EP3880690A2 (en) | 2021-09-22 |
| CA3119921A1 (en) | 2020-05-22 |
| CN113474356A (zh) | 2021-10-01 |
| MX2021005077A (es) | 2021-08-11 |
| KR20210087539A (ko) | 2021-07-12 |
| AU2019378162A1 (en) | 2021-05-20 |
| TW202031675A (zh) | 2020-09-01 |
| BR112021009341A2 (pt) | 2021-08-10 |
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