JP7522114B2 - ラマン分光法を使用してウイルス力価を決定するための方法 - Google Patents

ラマン分光法を使用してウイルス力価を決定するための方法 Download PDF

Info

Publication number
JP7522114B2
JP7522114B2 JP2021536747A JP2021536747A JP7522114B2 JP 7522114 B2 JP7522114 B2 JP 7522114B2 JP 2021536747 A JP2021536747 A JP 2021536747A JP 2021536747 A JP2021536747 A JP 2021536747A JP 7522114 B2 JP7522114 B2 JP 7522114B2
Authority
JP
Japan
Prior art keywords
wavenumber
wavenumber ranges
vip
virus
titer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021536747A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022515417A5 (https=
JP2022515417A (ja
Inventor
チャーチウェル、ジョン
オリヴィエ バラデス、マーク
マーシャル、ダミアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Therapy Catapult Ltd
Original Assignee
Cell Therapy Catapult Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapy Catapult Ltd filed Critical Cell Therapy Catapult Ltd
Publication of JP2022515417A publication Critical patent/JP2022515417A/ja
Publication of JP2022515417A5 publication Critical patent/JP2022515417A5/ja
Application granted granted Critical
Publication of JP7522114B2 publication Critical patent/JP7522114B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1293—Using chemometrical methods resolving multicomponent spectra
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1296—Using chemometrical methods using neural networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mathematical Physics (AREA)
  • Hematology (AREA)
  • Theoretical Computer Science (AREA)
  • Virology (AREA)
  • Data Mining & Analysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pure & Applied Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Computational Mathematics (AREA)
  • Algebra (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021536747A 2018-12-24 2019-12-23 ラマン分光法を使用してウイルス力価を決定するための方法 Active JP7522114B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1821206.8 2018-12-24
GB1821206.8A GB2580186B (en) 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy
PCT/GB2019/053695 WO2020136376A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy

Publications (3)

Publication Number Publication Date
JP2022515417A JP2022515417A (ja) 2022-02-18
JP2022515417A5 JP2022515417A5 (https=) 2023-01-05
JP7522114B2 true JP7522114B2 (ja) 2024-07-24

Family

ID=65364508

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021536747A Active JP7522114B2 (ja) 2018-12-24 2019-12-23 ラマン分光法を使用してウイルス力価を決定するための方法

Country Status (10)

Country Link
US (2) US11703455B2 (https=)
EP (1) EP3903096A1 (https=)
JP (1) JP7522114B2 (https=)
KR (1) KR20210104887A (https=)
CN (1) CN113490843B (https=)
AU (1) AU2019412791A1 (https=)
CA (1) CA3123168A1 (https=)
GB (1) GB2580186B (https=)
IL (1) IL284283B2 (https=)
WO (1) WO2020136376A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110609030B (zh) * 2019-10-22 2022-02-25 上海海关动植物与食品检验检疫技术中心 一种基于检出概率模型的拉曼快检性能综合评价方法
GB202010104D0 (en) * 2020-07-01 2020-08-12 Cell Therapy Catapult Ltd Method
EP4083852A1 (en) * 2021-04-30 2022-11-02 Universidad de Sevilla Virus detection and quantification method in fluid samples by digital processing diffuse optical reflectance hyperspectral images obtained in the visible and near infrared ranges
US12422367B2 (en) 2021-11-19 2025-09-23 Janssen Biotech, Inc. Methods for determination of virus titer in a sample using Raman spectroscopy
CN114628037A (zh) * 2022-02-25 2022-06-14 上海应用技术大学 一种基于深度学习卷积神经网络的新冠病毒识别预测模型
CN119256220A (zh) 2022-05-23 2025-01-03 豪夫迈·罗氏有限公司 用于区分aav颗粒血清型和aav颗粒荷载状态的基于拉曼的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090082220A1 (en) 2005-03-15 2009-03-26 Krause Duncan C Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US20090149344A1 (en) 2005-07-28 2009-06-11 Yiping Zhao Surface enhanced raman spectroscopy (sers) systems and methods of use thereof
US20120071352A1 (en) 2010-09-07 2012-03-22 National Cheng Kung University Non-labeled virus detection substrate, system, and method based on inverted multi-angular cavity arrays
CN105630743B (zh) 2015-12-24 2018-05-01 浙江大学 一种光谱波数的选择方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1242937A (zh) * 1998-07-28 2000-02-02 中国科学院生物物理研究所 多环醌类化合物的光敏作用杀灭血制品中艾滋病毒的方法
US20070134733A1 (en) * 2003-07-10 2007-06-14 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
JPWO2006051847A1 (ja) * 2004-11-12 2008-05-29 財団法人新産業創造研究機構 Ｈｉｖ等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置
JP2005140794A (ja) * 2005-01-13 2005-06-02 E Graw An 化学物質および微生物の検出のためのラマンオプトロードプロセスおよび装置
US7940387B2 (en) * 2005-03-15 2011-05-10 Univeristy Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
US20100279886A1 (en) * 2007-04-03 2010-11-04 University Of Rochester Two-dimensional photonic bandgap structures for ultrahigh-sensitivity biosensing
DE102008047240B4 (de) * 2008-09-11 2016-03-31 Friedrich-Schiller-Universität Jena Verfahren zur Identifikation von Einzelviren in einer Probe
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
US20120316446A1 (en) * 2011-06-07 2012-12-13 Sinisa Vukelic Raman spectral analysis for disease detection and monitoring
KR101523337B1 (ko) 2012-09-20 2015-05-28 주식회사 바이오센 라만 분광법 및 케모메트릭스를 이용한 식물의 바이러스 감염에 대한 분석방법
ES2877351T3 (es) * 2013-08-07 2021-11-16 Univ Wayne State Instrumento de detección portátil basado en micro-raman y método de detección
KR20150025220A (ko) * 2013-08-28 2015-03-10 고려대학교 산학협력단 표면 증폭 라만 산란 신호를 이용한 인플루엔자 바이러스 검출 방법
JP6375509B2 (ja) * 2013-12-17 2018-08-22 パナソニックＩｐマネジメント株式会社 報知装置、空気清浄機、および、報知方法
CN105603125B (zh) * 2016-03-09 2019-07-12 华南农业大学 一种快速检测禽病病毒的检测试剂盒及其检测方法
CN108088834B (zh) * 2017-09-13 2020-04-28 新疆大学 基于优化反向传播神经网络的包虫病血清拉曼光谱诊断仪
CN107937957B (zh) * 2017-11-23 2020-05-26 华中农业大学 表面增强拉曼基底的制备方法及该基底用于检测动物病毒

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090082220A1 (en) 2005-03-15 2009-03-26 Krause Duncan C Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US20090149344A1 (en) 2005-07-28 2009-06-11 Yiping Zhao Surface enhanced raman spectroscopy (sers) systems and methods of use thereof
US20120071352A1 (en) 2010-09-07 2012-03-22 National Cheng Kung University Non-labeled virus detection substrate, system, and method based on inverted multi-angular cavity arrays
CN105630743B (zh) 2015-12-24 2018-05-01 浙江大学 一种光谱波数的选择方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOMEDICAL OPTICS，2018年09月04日，VOL:23, NR:9，PAGE(S):097001(1-7)，http://dx.doi.org/10.1117/1.JBO.23.9.097001
Journal of Raman Spectroscopy，2019年01月10日，Vol.50, No.5，pp.620-628
Laser Phys. Lett.，2013年，Vol.10，035602(1-5)，http://dx.doi.org/10.1088/1612-2011/10/3/035602
PLOS ONE，2010年04月19日，VOL:5, NR:4，PAGE(S):E10222(1-9)，http://dx.doi.org/10.1371/journal.pone.0010222

Also Published As

Publication number Publication date
US12135289B2 (en) 2024-11-05
US20230384228A1 (en) 2023-11-30
GB201821206D0 (en) 2019-02-06
EP3903096A1 (en) 2021-11-03
US11703455B2 (en) 2023-07-18
AU2019412791A1 (en) 2021-07-08
CN113490843B (zh) 2024-08-09
IL284283A (en) 2021-08-31
CA3123168A1 (en) 2020-07-02
IL284283B1 (en) 2024-03-01
GB2580186A (en) 2020-07-15
IL284283B2 (en) 2024-07-01
GB2580186B (en) 2021-09-15
CN113490843A (zh) 2021-10-08
KR20210104887A (ko) 2021-08-25
JP2022515417A (ja) 2022-02-18
WO2020136376A1 (en) 2020-07-02
US20220018782A1 (en) 2022-01-20

Similar Documents

Publication Publication Date Title
JP7522114B2 (ja) ラマン分光法を使用してウイルス力価を決定するための方法
US20230236128A1 (en) Methods for analysing viruses using raman spectroscopy
Alexander Development of methodology based on commercialized SERS-active substrates for rapid discrimination of Poxviridae virions
JP6196220B2 (ja) 生体試料分析のための核磁気共鳴および近赤外線の使用
Li et al. Comprehensive, quantitative bioprocess productivity monitoring using fluorescence EEM spectroscopy and chemometrics
JP2023532568A5 (https=)
CN106574892A (zh) 用于确定蛋的受精和/或性别的非侵入性装置，以及相应的方法
Batool et al. SERS-based viral load quantification of hepatitis B virus from PCR products
Lin et al. Construction of Raman spectroscopic fingerprints for the detection of Fusarium wilt of banana in Taiwan
KR20150090152A (ko) 의학적 측정 곡선들을 평가하기 위한 방법
JP2022515417A5 (https=)
Dietrich et al. Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification
Dias et al. Laser wavelength and sample conditioning effects on biochemical monitoring of SARS-CoV-2 VLP production upstream stage by Raman spectroscopy
Zhu et al. Raman spectroscopic measurement of relative concentrations in mixtures of oral bacteria
Schmilovitch et al. Detection of bacteria with low-resolution Raman spectroscopy
Jiao et al. Determination of enantiomeric composition of tryptophan by using fluorescence spectroscopy combined with backward interval partial least squares
Guardalini et al. Monitoring by Raman spectroscopy of rabies virus‐like particles production since the initial development stages
Magalhães et al. Saccharomyces cerevisiae as a Model to Confirm the Ability of FTIR to Evaluate the Presence of Protein Aggregates
Grósz et al. Comparative Study of Laboratory Based Chlorophyll-A Determination Methods
Song et al. Rapid Classification of Respiratory Syncytial Virus and Sendai Virus by a Low-cost and Portable Near-infrared Spectrometer
Maghirang et al. Proof of Concept: NIR Spectroscopy Can Detect Rice Pathogen Burkholderia glumae in Artificially Inoculated Rice Seeds
Kuzmanovic et al. A novel application of small-angle scattering techniques: Quality assurance testing of virus quantification technology
JP4878263B2 (ja) 核酸濃度の判定方法及び核酸分析方法
Chaudary et al. Methodologies for label free Raman microspectroscopic monitoring of viral replication processes in vitro
Gao et al. Prediction of glucose concentration in a glucose-lactose mixture based on the reflective optical power at dual probe wavelengths

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210820

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20210820

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240614

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240702

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240711

R150 Certificate of patent or registration of utility model

Ref document number: 7522114

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150