CA3123168A1 - Methods for determining viral titre using raman spectroscopy - Google Patents

Methods for determining viral titre using raman spectroscopy Download PDF

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Publication number
CA3123168A1
CA3123168A1 CA3123168A CA3123168A CA3123168A1 CA 3123168 A1 CA3123168 A1 CA 3123168A1 CA 3123168 A CA3123168 A CA 3123168A CA 3123168 A CA3123168 A CA 3123168A CA 3123168 A1 CA3123168 A1 CA 3123168A1
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Prior art keywords
sample
wavenumber ranges
wavenumber
vip
viral
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CA3123168A
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English (en)
French (fr)
Inventor
John CHURCHWELL
Marc Olivier BARADEZ
Damian Marshall
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Cell Therapy Catapult Ltd
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Cell Therapy Catapult Ltd
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Publication of CA3123168A1 publication Critical patent/CA3123168A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1293—Using chemometrical methods resolving multicomponent spectra
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1296—Using chemometrical methods using neural networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mathematical Physics (AREA)
  • Hematology (AREA)
  • Theoretical Computer Science (AREA)
  • Virology (AREA)
  • Data Mining & Analysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pure & Applied Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Computational Mathematics (AREA)
  • Algebra (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3123168A 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy Pending CA3123168A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1821206.8 2018-12-24
GB1821206.8A GB2580186B (en) 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy
PCT/GB2019/053695 WO2020136376A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy

Publications (1)

Publication Number Publication Date
CA3123168A1 true CA3123168A1 (en) 2020-07-02

Family

ID=65364508

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3123168A Pending CA3123168A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy

Country Status (10)

Country Link
US (2) US11703455B2 (https=)
EP (1) EP3903096A1 (https=)
JP (1) JP7522114B2 (https=)
KR (1) KR20210104887A (https=)
CN (1) CN113490843B (https=)
AU (1) AU2019412791A1 (https=)
CA (1) CA3123168A1 (https=)
GB (1) GB2580186B (https=)
IL (1) IL284283B2 (https=)
WO (1) WO2020136376A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110609030B (zh) * 2019-10-22 2022-02-25 上海海关动植物与食品检验检疫技术中心 一种基于检出概率模型的拉曼快检性能综合评价方法
GB202010104D0 (en) * 2020-07-01 2020-08-12 Cell Therapy Catapult Ltd Method
EP4083852A1 (en) * 2021-04-30 2022-11-02 Universidad de Sevilla Virus detection and quantification method in fluid samples by digital processing diffuse optical reflectance hyperspectral images obtained in the visible and near infrared ranges
US12422367B2 (en) 2021-11-19 2025-09-23 Janssen Biotech, Inc. Methods for determination of virus titer in a sample using Raman spectroscopy
CN114628037A (zh) * 2022-02-25 2022-06-14 上海应用技术大学 一种基于深度学习卷积神经网络的新冠病毒识别预测模型
CN119256220A (zh) 2022-05-23 2025-01-03 豪夫迈·罗氏有限公司 用于区分aav颗粒血清型和aav颗粒荷载状态的基于拉曼的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
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CN1242937A (zh) * 1998-07-28 2000-02-02 中国科学院生物物理研究所 多环醌类化合物的光敏作用杀灭血制品中艾滋病毒的方法
US20070134733A1 (en) * 2003-07-10 2007-06-14 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
US7583379B2 (en) 2005-07-28 2009-09-01 University Of Georgia Research Foundation Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
JPWO2006051847A1 (ja) * 2004-11-12 2008-05-29 財団法人新産業創造研究機構 Ｈｉｖ等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置
JP2005140794A (ja) * 2005-01-13 2005-06-02 E Graw An 化学物質および微生物の検出のためのラマンオプトロードプロセスおよび装置
US7889334B2 (en) * 2005-03-15 2011-02-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US7940387B2 (en) * 2005-03-15 2011-05-10 Univeristy Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
US20100279886A1 (en) * 2007-04-03 2010-11-04 University Of Rochester Two-dimensional photonic bandgap structures for ultrahigh-sensitivity biosensing
DE102008047240B4 (de) * 2008-09-11 2016-03-31 Friedrich-Schiller-Universität Jena Verfahren zur Identifikation von Einzelviren in einer Probe
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
TWI487910B (zh) * 2010-09-07 2015-06-11 國立成功大學 倒多角錐陣列型免標定病毒檢測基板、系統及方法
US20120316446A1 (en) * 2011-06-07 2012-12-13 Sinisa Vukelic Raman spectral analysis for disease detection and monitoring
KR101523337B1 (ko) 2012-09-20 2015-05-28 주식회사 바이오센 라만 분광법 및 케모메트릭스를 이용한 식물의 바이러스 감염에 대한 분석방법
ES2877351T3 (es) * 2013-08-07 2021-11-16 Univ Wayne State Instrumento de detección portátil basado en micro-raman y método de detección
KR20150025220A (ko) * 2013-08-28 2015-03-10 고려대학교 산학협력단 표면 증폭 라만 산란 신호를 이용한 인플루엔자 바이러스 검출 방법
JP6375509B2 (ja) * 2013-12-17 2018-08-22 パナソニックＩｐマネジメント株式会社 報知装置、空気清浄機、および、報知方法
CN105630743B (zh) * 2015-12-24 2018-05-01 浙江大学 一种光谱波数的选择方法
CN105603125B (zh) * 2016-03-09 2019-07-12 华南农业大学 一种快速检测禽病病毒的检测试剂盒及其检测方法
CN108088834B (zh) * 2017-09-13 2020-04-28 新疆大学 基于优化反向传播神经网络的包虫病血清拉曼光谱诊断仪
CN107937957B (zh) * 2017-11-23 2020-05-26 华中农业大学 表面增强拉曼基底的制备方法及该基底用于检测动物病毒

Also Published As

Publication number Publication date
US12135289B2 (en) 2024-11-05
US20230384228A1 (en) 2023-11-30
JP7522114B2 (ja) 2024-07-24
GB201821206D0 (en) 2019-02-06
EP3903096A1 (en) 2021-11-03
US11703455B2 (en) 2023-07-18
AU2019412791A1 (en) 2021-07-08
CN113490843B (zh) 2024-08-09
IL284283A (en) 2021-08-31
IL284283B1 (en) 2024-03-01
GB2580186A (en) 2020-07-15
IL284283B2 (en) 2024-07-01
GB2580186B (en) 2021-09-15
CN113490843A (zh) 2021-10-08
KR20210104887A (ko) 2021-08-25
JP2022515417A (ja) 2022-02-18
WO2020136376A1 (en) 2020-07-02
US20220018782A1 (en) 2022-01-20

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