GB2580186B - Monitoring viral titre using Raman Spectroscopy - Google Patents

Monitoring viral titre using Raman Spectroscopy Download PDF

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Publication number
GB2580186B
GB2580186B GB1821206.8A GB201821206A GB2580186B GB 2580186 B GB2580186 B GB 2580186B GB 201821206 A GB201821206 A GB 201821206A GB 2580186 B GB2580186 B GB 2580186B
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United Kingdom
Prior art keywords
raman spectroscopy
viral titre
monitoring viral
monitoring
titre
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1821206.8A
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English (en)
Other versions
GB201821206D0 (en
GB2580186A (en
Inventor
Churchwell John
Oliver Baradez Marc
Marshall Damian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Therapy Catapult Ltd
Original Assignee
Cell Therapy Catapult Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapy Catapult Ltd filed Critical Cell Therapy Catapult Ltd
Priority to GB1821206.8A priority Critical patent/GB2580186B/en
Publication of GB201821206D0 publication Critical patent/GB201821206D0/en
Priority to IL284283A priority patent/IL284283B2/en
Priority to CA3123168A priority patent/CA3123168A1/en
Priority to EP19831870.1A priority patent/EP3903096A1/en
Priority to AU2019412791A priority patent/AU2019412791A1/en
Priority to CN201980092894.2A priority patent/CN113490843B/zh
Priority to US17/417,466 priority patent/US11703455B2/en
Priority to PCT/GB2019/053695 priority patent/WO2020136376A1/en
Priority to KR1020217023614A priority patent/KR20210104887A/ko
Priority to JP2021536747A priority patent/JP7522114B2/ja
Publication of GB2580186A publication Critical patent/GB2580186A/en
Application granted granted Critical
Publication of GB2580186B publication Critical patent/GB2580186B/en
Priority to US18/324,728 priority patent/US12135289B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1293—Using chemometrical methods resolving multicomponent spectra
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1296—Using chemometrical methods using neural networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mathematical Physics (AREA)
  • Hematology (AREA)
  • Theoretical Computer Science (AREA)
  • Virology (AREA)
  • Data Mining & Analysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pure & Applied Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Computational Mathematics (AREA)
  • Algebra (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB1821206.8A 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy Active GB2580186B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB1821206.8A GB2580186B (en) 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy
US17/417,466 US11703455B2 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy
KR1020217023614A KR20210104887A (ko) 2018-12-24 2019-12-23 라만 분광법을 사용하여 바이러스 역가를 측정하는 방법
EP19831870.1A EP3903096A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy
AU2019412791A AU2019412791A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using Raman spectroscopy
CN201980092894.2A CN113490843B (zh) 2018-12-24 2019-12-23 采用拉曼光谱确定病毒滴度的方法
IL284283A IL284283B2 (en) 2018-12-24 2019-12-23 Methods for viral titer determination using Raman spectroscopy
PCT/GB2019/053695 WO2020136376A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy
CA3123168A CA3123168A1 (en) 2018-12-24 2019-12-23 Methods for determining viral titre using raman spectroscopy
JP2021536747A JP7522114B2 (ja) 2018-12-24 2019-12-23 ラマン分光法を使用してウイルス力価を決定するための方法
US18/324,728 US12135289B2 (en) 2018-12-24 2023-05-26 Methods for determining viral titre using raman spectroscopy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1821206.8A GB2580186B (en) 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy

Publications (3)

Publication Number Publication Date
GB201821206D0 GB201821206D0 (en) 2019-02-06
GB2580186A GB2580186A (en) 2020-07-15
GB2580186B true GB2580186B (en) 2021-09-15

Family

ID=65364508

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1821206.8A Active GB2580186B (en) 2018-12-24 2018-12-24 Monitoring viral titre using Raman Spectroscopy

Country Status (10)

Country Link
US (2) US11703455B2 (https=)
EP (1) EP3903096A1 (https=)
JP (1) JP7522114B2 (https=)
KR (1) KR20210104887A (https=)
CN (1) CN113490843B (https=)
AU (1) AU2019412791A1 (https=)
CA (1) CA3123168A1 (https=)
GB (1) GB2580186B (https=)
IL (1) IL284283B2 (https=)
WO (1) WO2020136376A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110609030B (zh) * 2019-10-22 2022-02-25 上海海关动植物与食品检验检疫技术中心 一种基于检出概率模型的拉曼快检性能综合评价方法
GB202010104D0 (en) * 2020-07-01 2020-08-12 Cell Therapy Catapult Ltd Method
EP4083852A1 (en) * 2021-04-30 2022-11-02 Universidad de Sevilla Virus detection and quantification method in fluid samples by digital processing diffuse optical reflectance hyperspectral images obtained in the visible and near infrared ranges
US12422367B2 (en) 2021-11-19 2025-09-23 Janssen Biotech, Inc. Methods for determination of virus titer in a sample using Raman spectroscopy
CN114628037A (zh) * 2022-02-25 2022-06-14 上海应用技术大学 一种基于深度学习卷积神经网络的新冠病毒识别预测模型
CN119256220A (zh) 2022-05-23 2025-01-03 豪夫迈·罗氏有限公司 用于区分aav颗粒血清型和aav颗粒荷载状态的基于拉曼的方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005031301A2 (en) * 2003-07-10 2005-04-07 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
WO2006051847A1 (ja) * 2004-11-12 2006-05-18 The New Industry Research Organization Ｈｉｖ等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置
US20090082220A1 (en) * 2005-03-15 2009-03-26 Krause Duncan C Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US20100279886A1 (en) * 2007-04-03 2010-11-04 University Of Rochester Two-dimensional photonic bandgap structures for ultrahigh-sensitivity biosensing
US20110165558A1 (en) * 2008-09-11 2011-07-07 Popp Juergen Method for identifying individual viruses in a sample
WO2012019102A2 (en) * 2010-08-05 2012-02-09 Massachusetts Institute Of Technology Portable raman diagnostic system
WO2015021300A1 (en) * 2013-08-07 2015-02-12 Wayne State University Hand-held micro-raman based detection instrument and method of detection
CN105603125A (zh) * 2016-03-09 2016-05-25 华南农业大学 一种快速检测禽病病毒的检测试剂盒及其检测方法

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CN1242937A (zh) * 1998-07-28 2000-02-02 中国科学院生物物理研究所 多环醌类化合物的光敏作用杀灭血制品中艾滋病毒的方法
US7583379B2 (en) 2005-07-28 2009-09-01 University Of Georgia Research Foundation Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
JP2005140794A (ja) * 2005-01-13 2005-06-02 E Graw An 化学物質および微生物の検出のためのラマンオプトロードプロセスおよび装置
US7940387B2 (en) * 2005-03-15 2011-05-10 Univeristy Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
TWI487910B (zh) * 2010-09-07 2015-06-11 國立成功大學 倒多角錐陣列型免標定病毒檢測基板、系統及方法
US20120316446A1 (en) * 2011-06-07 2012-12-13 Sinisa Vukelic Raman spectral analysis for disease detection and monitoring
KR101523337B1 (ko) 2012-09-20 2015-05-28 주식회사 바이오센 라만 분광법 및 케모메트릭스를 이용한 식물의 바이러스 감염에 대한 분석방법
KR20150025220A (ko) * 2013-08-28 2015-03-10 고려대학교 산학협력단 표면 증폭 라만 산란 신호를 이용한 인플루엔자 바이러스 검출 방법
JP6375509B2 (ja) * 2013-12-17 2018-08-22 パナソニックＩｐマネジメント株式会社 報知装置、空気清浄機、および、報知方法
CN105630743B (zh) * 2015-12-24 2018-05-01 浙江大学 一种光谱波数的选择方法
CN108088834B (zh) * 2017-09-13 2020-04-28 新疆大学 基于优化反向传播神经网络的包虫病血清拉曼光谱诊断仪
CN107937957B (zh) * 2017-11-23 2020-05-26 华中农业大学 表面增强拉曼基底的制备方法及该基底用于检测动物病毒

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005031301A2 (en) * 2003-07-10 2005-04-07 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
WO2006051847A1 (ja) * 2004-11-12 2006-05-18 The New Industry Research Organization Ｈｉｖ等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置
US20090082220A1 (en) * 2005-03-15 2009-03-26 Krause Duncan C Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US20100279886A1 (en) * 2007-04-03 2010-11-04 University Of Rochester Two-dimensional photonic bandgap structures for ultrahigh-sensitivity biosensing
US20110165558A1 (en) * 2008-09-11 2011-07-07 Popp Juergen Method for identifying individual viruses in a sample
WO2012019102A2 (en) * 2010-08-05 2012-02-09 Massachusetts Institute Of Technology Portable raman diagnostic system
WO2015021300A1 (en) * 2013-08-07 2015-02-12 Wayne State University Hand-held micro-raman based detection instrument and method of detection
CN105603125A (zh) * 2016-03-09 2016-05-25 华南农业大学 一种快速检测禽病病毒的检测试剂盒及其检测方法

Non-Patent Citations (2)

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Title
DRISKELL, J. et al; "Rapid and sensitive detection of rotavirus molecular signatures using surface enhanced Raman spectroscopy", PLoS ONE, Vol 5, No 4, 2010, Doi:10.1371/journal.pone.0010222 *
LEE, J.H; "Rapid and sensitive determination of HIV-1 virus based on surface enhanced Raman spectroscopy", J. Biomed. Nanotechnol. 2015, 11 (12), pp 2223-2230 *

Also Published As

Publication number Publication date
US12135289B2 (en) 2024-11-05
US20230384228A1 (en) 2023-11-30
JP7522114B2 (ja) 2024-07-24
GB201821206D0 (en) 2019-02-06
EP3903096A1 (en) 2021-11-03
US11703455B2 (en) 2023-07-18
AU2019412791A1 (en) 2021-07-08
CN113490843B (zh) 2024-08-09
IL284283A (en) 2021-08-31
CA3123168A1 (en) 2020-07-02
IL284283B1 (en) 2024-03-01
GB2580186A (en) 2020-07-15
IL284283B2 (en) 2024-07-01
CN113490843A (zh) 2021-10-08
KR20210104887A (ko) 2021-08-25
JP2022515417A (ja) 2022-02-18
WO2020136376A1 (en) 2020-07-02
US20220018782A1 (en) 2022-01-20

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