JP7492597B2 - Ｇｐｒ５２モジュレーター化合物 - Google Patents
Ｇｐｒ５２モジュレーター化合物 Download PDFInfo
- Publication number
- JP7492597B2 JP7492597B2 JP2022555137A JP2022555137A JP7492597B2 JP 7492597 B2 JP7492597 B2 JP 7492597B2 JP 2022555137 A JP2022555137 A JP 2022555137A JP 2022555137 A JP2022555137 A JP 2022555137A JP 7492597 B2 JP7492597 B2 JP 7492597B2
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- pyridin
- trifluoromethyl
- benzyl
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Amplifiers (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2003668.7A GB202003668D0 (en) | 2020-03-13 | 2020-03-13 | GPR52 Modulator compounds |
| GB2003668.7 | 2020-03-13 | ||
| PCT/GB2021/050638 WO2021181122A1 (en) | 2020-03-13 | 2021-03-15 | Gpr52 modulator compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023519666A JP2023519666A (ja) | 2023-05-12 |
| JP2023519666A5 JP2023519666A5 (https=) | 2024-03-27 |
| JP7492597B2 true JP7492597B2 (ja) | 2024-05-29 |
Family
ID=70453676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022555137A Active JP7492597B2 (ja) | 2020-03-13 | 2021-03-15 | Ｇｐｒ５２モジュレーター化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20240254101A1 (https=) |
| EP (1) | EP4117784B1 (https=) |
| JP (1) | JP7492597B2 (https=) |
| KR (1) | KR20220152296A (https=) |
| CN (1) | CN115515681B (https=) |
| AU (1) | AU2021235257A1 (https=) |
| BR (1) | BR112022018287A2 (https=) |
| CA (1) | CA3175429A1 (https=) |
| DK (1) | DK4117784T3 (https=) |
| ES (1) | ES2992600T3 (https=) |
| FI (1) | FI4117784T3 (https=) |
| GB (1) | GB202003668D0 (https=) |
| HR (1) | HRP20241375T1 (https=) |
| HU (1) | HUE068758T2 (https=) |
| IL (1) | IL296413B2 (https=) |
| LT (1) | LT4117784T (https=) |
| MX (1) | MX2022011333A (https=) |
| PL (1) | PL4117784T3 (https=) |
| PT (1) | PT4117784T (https=) |
| RS (1) | RS66063B1 (https=) |
| SI (1) | SI4117784T1 (https=) |
| SM (1) | SMT202400402T1 (https=) |
| WO (1) | WO2021181122A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202206413A (zh) | 2020-04-22 | 2022-02-16 | 美商紐羅克里生物科學有限公司 | Gpr52調節劑及其使用方法 |
| EP4330232A1 (en) * | 2021-04-26 | 2024-03-06 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| GB202113186D0 (en) | 2021-09-15 | 2021-10-27 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| WO2024091541A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| JP2026508053A (ja) * | 2022-10-26 | 2026-03-10 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｇｐｒ５２モジュレーターとしての化合物および組成物 |
| WO2024091542A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| WO2025252061A1 (zh) * | 2024-06-04 | 2025-12-11 | 海思科医药集团股份有限公司 | 一种gpr52激动剂及其在医药上的应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009107391A1 (ja) | 2008-02-27 | 2009-09-03 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| WO2011078360A1 (ja) | 2009-12-24 | 2011-06-30 | 武田薬品工業株式会社 | アミド化合物 |
| WO2011093352A1 (ja) | 2010-01-27 | 2011-08-04 | 武田薬品工業株式会社 | チアゾール誘導体 |
| JP2018519253A (ja) | 2015-04-29 | 2018-07-19 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド |
| WO2019053090A1 (en) | 2017-09-13 | 2019-03-21 | Novartis Ag | DIPHENYL DERIVATIVES AND USES THEREOF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005037797A1 (en) * | 2003-10-21 | 2005-04-28 | Pharmacia Corporation | Substituted pyrazole urea compounds for the treatment of inflammation |
-
2020
- 2020-03-13 GB GBGB2003668.7A patent/GB202003668D0/en not_active Ceased
-
2021
- 2021-03-15 HR HRP20241375TT patent/HRP20241375T1/hr unknown
- 2021-03-15 ES ES21713103T patent/ES2992600T3/es active Active
- 2021-03-15 EP EP21713103.6A patent/EP4117784B1/en active Active
- 2021-03-15 SI SI202130212T patent/SI4117784T1/sl unknown
- 2021-03-15 US US17/909,792 patent/US20240254101A1/en active Pending
- 2021-03-15 RS RS20241089A patent/RS66063B1/sr unknown
- 2021-03-15 AU AU2021235257A patent/AU2021235257A1/en active Pending
- 2021-03-15 IL IL296413A patent/IL296413B2/en unknown
- 2021-03-15 WO PCT/GB2021/050638 patent/WO2021181122A1/en not_active Ceased
- 2021-03-15 LT LTEPPCT/GB2021/050638T patent/LT4117784T/lt unknown
- 2021-03-15 DK DK21713103.6T patent/DK4117784T3/da active
- 2021-03-15 PT PT217131036T patent/PT4117784T/pt unknown
- 2021-03-15 CA CA3175429A patent/CA3175429A1/en active Pending
- 2021-03-15 SM SM20240402T patent/SMT202400402T1/it unknown
- 2021-03-15 MX MX2022011333A patent/MX2022011333A/es unknown
- 2021-03-15 PL PL21713103.6T patent/PL4117784T3/pl unknown
- 2021-03-15 KR KR1020227035100A patent/KR20220152296A/ko active Pending
- 2021-03-15 HU HUE21713103A patent/HUE068758T2/hu unknown
- 2021-03-15 BR BR112022018287A patent/BR112022018287A2/pt unknown
- 2021-03-15 FI FIEP21713103.6T patent/FI4117784T3/fi active
- 2021-03-15 CN CN202180033813.9A patent/CN115515681B/zh active Active
- 2021-03-15 JP JP2022555137A patent/JP7492597B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009107391A1 (ja) | 2008-02-27 | 2009-09-03 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| WO2011078360A1 (ja) | 2009-12-24 | 2011-06-30 | 武田薬品工業株式会社 | アミド化合物 |
| WO2011093352A1 (ja) | 2010-01-27 | 2011-08-04 | 武田薬品工業株式会社 | チアゾール誘導体 |
| JP2018519253A (ja) | 2015-04-29 | 2018-07-19 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド |
| WO2019053090A1 (en) | 2017-09-13 | 2019-03-21 | Novartis Ag | DIPHENYL DERIVATIVES AND USES THEREOF |
Non-Patent Citations (2)
| Title |
|---|
| NAKAHATA, T. et al.，Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists，Bioorganic and Medicinal Chemistry，2018年02月10日，Vol.26，pp.1598-1608 |
| SETOH, M. et al.，Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52，Journal of Medicinal Chmeistry，Vol.57，2014年06月02日，pp.5226-5237 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4117784A1 (en) | 2023-01-18 |
| SMT202400402T1 (it) | 2024-11-15 |
| GB202003668D0 (en) | 2020-04-29 |
| IL296413A (en) | 2022-11-01 |
| ES2992600T3 (en) | 2024-12-16 |
| CA3175429A1 (en) | 2021-09-16 |
| AU2021235257A1 (en) | 2022-10-06 |
| SI4117784T1 (sl) | 2025-03-31 |
| LT4117784T (lt) | 2024-10-25 |
| EP4117784B1 (en) | 2024-08-28 |
| DK4117784T3 (da) | 2024-10-14 |
| CN115515681A (zh) | 2022-12-23 |
| CN115515681B (zh) | 2024-09-03 |
| JP2023519666A (ja) | 2023-05-12 |
| RS66063B1 (sr) | 2024-11-29 |
| IL296413B1 (en) | 2025-11-01 |
| FI4117784T3 (fi) | 2024-10-10 |
| US20240254101A1 (en) | 2024-08-01 |
| KR20220152296A (ko) | 2022-11-15 |
| MX2022011333A (es) | 2022-12-08 |
| HUE068758T2 (hu) | 2025-01-28 |
| HRP20241375T1 (hr) | 2024-12-20 |
| PL4117784T3 (pl) | 2025-01-13 |
| BR112022018287A2 (pt) | 2022-11-22 |
| WO2021181122A1 (en) | 2021-09-16 |
| PT4117784T (pt) | 2024-10-07 |
| IL296413B2 (en) | 2026-03-01 |
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