JP7489370B2 - ピラゾール－アミド化合物の非晶質固体分散体 - Google Patents

ピラゾール－アミド化合物の非晶質固体分散体 Download PDF

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JP7489370B2
JP7489370B2 JP2021504101A JP2021504101A JP7489370B2 JP 7489370 B2 JP7489370 B2 JP 7489370B2 JP 2021504101 A JP2021504101 A JP 2021504101A JP 2021504101 A JP2021504101 A JP 2021504101A JP 7489370 B2 JP7489370 B2 JP 7489370B2
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formula
pharma
hydrate
solid dispersion
ceutically acceptable
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JPWO2020179770A1 (https=
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由博 中島
駿 中島
由匡 森
智司 野澤
嘉昭 石川
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Japan Tobacco Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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JP2021504101A 2019-03-04 2020-03-03 ピラゾール－アミド化合物の非晶質固体分散体 Active JP7489370B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019038327 2019-03-04
JP2019038327 2019-03-04
PCT/JP2020/008840 WO2020179770A1 (ja) 2019-03-04 2020-03-03 ピラゾール－アミド化合物の非晶質固体分散体

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JPWO2020179770A1 JPWO2020179770A1 (https=) 2020-09-10
JP7489370B2 true JP7489370B2 (ja) 2024-05-23

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US (1) US20220409548A1 (https=)
EP (1) EP3936127B1 (https=)
JP (1) JP7489370B2 (https=)
KR (1) KR20210135266A (https=)
CN (1) CN113490492B (https=)
AU (1) AU2020232630A1 (https=)
BR (1) BR112021016815A2 (https=)
CA (1) CA3132296A1 (https=)
MX (1) MX2021010692A (https=)
WO (1) WO2020179770A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117897382A (zh) * 2021-09-01 2024-04-16 日本烟草产业株式会社 含氮三环化合物及其药物用途
MX2024005341A (es) * 2021-11-03 2024-05-20 Beijing Innocare Pharma Tech Co Ltd Dispersion solida amorfa que comprende (s)-1-(1-acriloilpirrolidin -3-il)-3-((3,5-dimetoxifenil)etinil)-5-(metilamino)-1h-pirazol-4- carboxamida.
KR102769218B1 (ko) * 2022-09-28 2025-02-24 주식회사 제이디바이오사이언스 신규한 플루오렌 유도체 및 이의 용도
JP2024091760A (ja) * 2024-04-15 2024-07-05 信越化学工業株式会社 非晶質固体分散体を含む複合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009530415A (ja) 2006-03-20 2009-08-27 バーテックス ファーマシューティカルズ インコーポレイテッド 医薬組成物
JP2013528218A (ja) 2010-06-09 2013-07-08 アボット・ラボラトリーズ キナーゼ阻害剤を含有する固体分散体
JP2014521745A (ja) 2011-08-16 2014-08-28 メルク・シャープ・アンド・ドーム・コーポレーション 安定した非晶質分散体を調製するための無機マトリックスと有機ポリマーの組み合わせの使用
WO2018021508A1 (ja) 2016-07-29 2018-02-01 日本たばこ産業株式会社 ピラゾール－アミド化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5475561B2 (ja) * 2010-06-14 2014-04-16 ポリプラスチックス株式会社 充填材の配向解析方法
MY182884A (en) 2013-03-15 2021-02-05 Japan Tobacco Inc Pyrazole-amide compound and medicinal uses therefor
WO2018013693A1 (en) * 2016-07-13 2018-01-18 Celgene Corporation Solid dispersions and cocrystals comprising 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione compositions and methods of use thereof
CN108785256B (zh) * 2017-04-28 2021-06-29 江苏恒瑞医药股份有限公司 一种固体分散体及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009530415A (ja) 2006-03-20 2009-08-27 バーテックス ファーマシューティカルズ インコーポレイテッド 医薬組成物
JP2013528218A (ja) 2010-06-09 2013-07-08 アボット・ラボラトリーズ キナーゼ阻害剤を含有する固体分散体
JP2014521745A (ja) 2011-08-16 2014-08-28 メルク・シャープ・アンド・ドーム・コーポレーション 安定した非晶質分散体を調製するための無機マトリックスと有機ポリマーの組み合わせの使用
WO2018021508A1 (ja) 2016-07-29 2018-02-01 日本たばこ産業株式会社 ピラゾール－アミド化合物の製造方法

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CN113490492B (zh) 2024-09-27
BR112021016815A2 (pt) 2021-11-16
US20220409548A1 (en) 2022-12-29
EP3936127A1 (en) 2022-01-12
EP3936127B1 (en) 2025-04-30
MX2021010692A (es) 2021-10-01
KR20210135266A (ko) 2021-11-12
JPWO2020179770A1 (https=) 2020-09-10
WO2020179770A1 (ja) 2020-09-10
CN113490492A (zh) 2021-10-08
EP3936127A4 (en) 2022-12-14
CA3132296A1 (en) 2020-09-10
AU2020232630A1 (en) 2021-09-16

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