JP7487921B2 - チロシンキナーゼ阻害剤及びその応用 - Google Patents
チロシンキナーゼ阻害剤及びその応用 Download PDFInfo
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Classifications
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/22—Oxygen atoms attached in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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| CN201610822529.0A CN107235896B (zh) | 2016-09-13 | 2016-09-13 | 酪氨酸激酶抑制剂及其应用 |
| CN201610822529.0 | 2016-09-13 | ||
| PCT/CN2017/089501 WO2018049861A1 (zh) | 2016-09-13 | 2017-06-22 | 酪氨酸激酶抑制剂及其应用 |
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| JP2019529435A JP2019529435A (ja) | 2019-10-17 |
| JP2019529435A5 JP2019529435A5 (enExample) | 2020-11-12 |
| JPWO2018049861A5 JPWO2018049861A5 (enExample) | 2024-03-06 |
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| CA3070013A1 (en) | 2017-07-18 | 2019-01-24 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyridine-derivatives |
| WO2019148036A1 (en) | 2018-01-26 | 2019-08-01 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| EP3743417A1 (en) | 2018-01-26 | 2020-12-02 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| SG11202006921PA (en) * | 2018-01-26 | 2020-08-28 | Exelixis Inc | Compounds for the treatment of kinase-dependent disorders |
| AR119069A1 (es) * | 2019-06-04 | 2021-11-24 | Exelixis Inc | Compuestos para el tratamiento de trastornos dependientes de quinasas |
| CN112358469A (zh) * | 2020-03-18 | 2021-02-12 | 北京康辰药业股份有限公司 | 血管生成抑制剂、其制备方法及其应用 |
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| JP2012521348A (ja) | 2009-03-21 | 2012-09-13 | クイ ニング | アミノエステル誘導体、その塩、及び使用方法 |
| JP2013537197A (ja) | 2010-09-12 | 2013-09-30 | アドヴェンチェン ラボラトリーズ，エルエルシー | ｃ−Ｍｅｔキナーゼ阻害剤としての化合物 |
| CN104817497A (zh) | 2015-03-20 | 2015-08-05 | 南京众睿缘生物科技有限公司 | 一种炔代喹啉衍生物及其制备方法和用途 |
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| EP2392565B1 (en) * | 2003-09-26 | 2014-03-19 | Exelixis, Inc. | c-Met modulators and methods of use |
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| KR20110075016A (ko) * | 2008-10-14 | 2011-07-05 | 닝 시 | 화합물 및 사용 방법 |
| CN105884695B (zh) * | 2015-02-13 | 2019-02-26 | 山东轩竹医药科技有限公司 | 杂环衍生物类酪氨酸激酶抑制剂 |
| CN105085416A (zh) * | 2015-08-25 | 2015-11-25 | 佛山市赛维斯医药科技有限公司 | 一类硝基取代的双烷氧苯并喹唑啉类酪氨酸激酶抑制剂及用途 |
| CN105001168A (zh) * | 2015-08-25 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 三烷氧基取代的苯并喹唑啉类酪氨酸激酶抑制剂及其用途 |
| CN105017163A (zh) * | 2015-08-25 | 2015-11-04 | 佛山市赛维斯医药科技有限公司 | 双乙氧基苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及其用途 |
| CN105218445B (zh) * | 2015-08-25 | 2018-05-22 | 江苏中邦制药有限公司 | 一种酪氨酸激酶抑制剂Foretinib的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012521348A (ja) | 2009-03-21 | 2012-09-13 | クイ ニング | アミノエステル誘導体、その塩、及び使用方法 |
| JP2013537197A (ja) | 2010-09-12 | 2013-09-30 | アドヴェンチェン ラボラトリーズ，エルエルシー | ｃ−Ｍｅｔキナーゼ阻害剤としての化合物 |
| CN104817497A (zh) | 2015-03-20 | 2015-08-05 | 南京众睿缘生物科技有限公司 | 一种炔代喹啉衍生物及其制备方法和用途 |
Non-Patent Citations (1)
| Title |
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| Ａｎｔｉ－Ｃａｎｃｅｒ Ａｇｅｎｔｓ ｉｎ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，２０１０，Ｖｏｌ．１０，Ｎｏ．１，ｐ．７－２７ |
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| KR20190045354A (ko) | 2019-05-02 |
| CN107235896B (zh) | 2019-11-05 |
| JP2019529435A (ja) | 2019-10-17 |
| CN110437145A (zh) | 2019-11-12 |
| EP3511327A1 (en) | 2019-07-17 |
| EP3511327B1 (en) | 2021-10-27 |
| EP3511327A4 (en) | 2019-08-07 |
| KR102382039B1 (ko) | 2022-04-01 |
| CN107235896A (zh) | 2017-10-10 |
| US10882853B2 (en) | 2021-01-05 |
| AU2017325641A1 (en) | 2019-04-11 |
| AU2017325641B2 (en) | 2021-08-26 |
| US20190248772A1 (en) | 2019-08-15 |
| KR20210143935A (ko) | 2021-11-29 |
| ES2902549T3 (es) | 2022-03-28 |
| WO2018049861A1 (zh) | 2018-03-22 |
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