JP7478142B2 - Ｓａｒｍ１阻害剤 - Google Patents

Ｓａｒｍ１阻害剤 Download PDF

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Publication number
JP7478142B2
JP7478142B2 JP2021518046A JP2021518046A JP7478142B2 JP 7478142 B2 JP7478142 B2 JP 7478142B2 JP 2021518046 A JP2021518046 A JP 2021518046A JP 2021518046 A JP2021518046 A JP 2021518046A JP 7478142 B2 JP7478142 B2 JP 7478142B2
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certain embodiments
disease
sarm1
compounds
compound
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JP2021528488A5 (enExample
JP2021528488A (ja
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ロバート・オーエン・ヒューズ
ラジェシュ・デブラジ
トッド・ボサナック
リチャード・アンドリュー・ジャージェス－パイク
アンドリュー・サイモン・ブリアリー
ジョナサン・ベントリー
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2021518046A 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤 Active JP7478142B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682045P 2018-06-07 2018-06-07
US62/682,045 2018-06-07
PCT/US2019/035839 WO2019236884A1 (en) 2018-06-07 2019-06-06 Inhibitors of sarm1

Publications (3)

Publication Number Publication Date
JP2021528488A JP2021528488A (ja) 2021-10-21
JP2021528488A5 JP2021528488A5 (enExample) 2022-06-10
JP7478142B2 true JP7478142B2 (ja) 2024-05-02

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Family Applications (1)

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JP2021518046A Active JP7478142B2 (ja) 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤

Country Status (7)

Country Link
US (1) US12448374B2 (enExample)
EP (1) EP3801499B1 (enExample)
JP (1) JP7478142B2 (enExample)
CN (1) CN112839648B (enExample)
ES (1) ES2988933T3 (enExample)
MA (1) MA52809A (enExample)
WO (1) WO2019236884A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA52813A (fr) 2018-06-07 2021-04-14 Disarm Therapeutics Inc Inhibiteurs de sarm1
EP3801503A4 (en) 2018-06-07 2021-12-08 Disarm Therapeutics, Inc. INHIBITORS OF SARM1
CN113164508B (zh) 2018-12-19 2025-07-08 达萨玛治疗公司 与神经保护剂组合的sarm1抑制剂
US12624025B2 (en) 2019-06-06 2026-05-12 Disarm Therapeutics, Inc. Inhibitors of SARM1
WO2020252229A2 (en) 2019-06-14 2020-12-17 Disarm Therapeutics, Inc. Inhibitors of sarm1
US12441719B2 (en) 2019-09-12 2025-10-14 Disarm Therapeutics, Inc. Inhibitors of SARM1
AU2020391206A1 (en) * 2019-11-26 2022-05-19 Disarm Therapeutics, Inc. Methods and compositions for neuroprotection
WO2021207302A1 (en) 2020-04-09 2021-10-14 Disarm Therapeutics, Inc. Indazole derivatives as inhibitors of sarm1
EP4132928B1 (en) * 2020-04-09 2025-12-24 Disarm Therapeutics, Inc. Condensed pyrazole derivatives as inhibitors of sarm1
TWI904906B (zh) * 2020-08-24 2025-11-11 美商達薩瑪治療公司 Sarm1之抑制劑
JP2025539084A (ja) * 2022-11-12 2025-12-03 ケンブリッジ・エンタープライズ・リミテッド 療法及び化粧品での使用のためのｓａｒｍ１作用薬
TW202509019A (zh) * 2023-04-27 2025-03-01 香港商維泰瑞隆（香港）生物科技有限公司 Sarm1調節子、其製劑及用途
CN116836162B (zh) * 2023-05-24 2025-09-05 南方医科大学 吡唑[4,3-c]吡啶类化合物或其药学上可接受的盐及其应用
WO2026086928A1 (en) * 2024-10-25 2026-04-30 Sironax Ltd. Sarm1 modulators, preparations, and uses thereof

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