JP7478142B2 - Ｓａｒｍ１阻害剤 - Google Patents

Ｓａｒｍ１阻害剤 Download PDF

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Publication number
JP7478142B2
JP7478142B2 JP2021518046A JP2021518046A JP7478142B2 JP 7478142 B2 JP7478142 B2 JP 7478142B2 JP 2021518046 A JP2021518046 A JP 2021518046A JP 2021518046 A JP2021518046 A JP 2021518046A JP 7478142 B2 JP7478142 B2 JP 7478142B2
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certain embodiments
disease
sarm1
compounds
compound
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JPWO2019236884A5 (enExample
JP2021528488A (ja
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ロバート・オーエン・ヒューズ
ラジェシュ・デブラジ
トッド・ボサナック
リチャード・アンドリュー・ジャージェス－パイク
アンドリュー・サイモン・ブリアリー
ジョナサン・ベントリー
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2021518046A 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤 Active JP7478142B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682045P 2018-06-07 2018-06-07
US62/682,045 2018-06-07
PCT/US2019/035839 WO2019236884A1 (en) 2018-06-07 2019-06-06 Inhibitors of sarm1

Publications (3)

Publication Number Publication Date
JP2021528488A JP2021528488A (ja) 2021-10-21
JPWO2019236884A5 JPWO2019236884A5 (enExample) 2022-06-10
JP7478142B2 true JP7478142B2 (ja) 2024-05-02

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Family Applications (1)

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JP2021518046A Active JP7478142B2 (ja) 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤

Country Status (8)

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US (1) US12448374B2 (enExample)
EP (1) EP3801499B1 (enExample)
JP (1) JP7478142B2 (enExample)
CN (1) CN112839648B (enExample)
CA (1) CA3102598A1 (enExample)
ES (1) ES2988933T3 (enExample)
MA (1) MA52809A (enExample)
WO (1) WO2019236884A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
JP2021527125A (ja) 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドＤｉｓａｒｍ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｓａｒｍ１阻害剤
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
US12083114B2 (en) 2018-12-19 2024-09-10 Disarm Therapeutics, Inc. Inhibitors of SARM1 in combination with neuro-protective agents
EP4028013A4 (en) 2019-09-12 2023-10-18 Disarm Therapeutics, Inc. MRSA1 INHIBITORS
BR112022009772A2 (pt) * 2019-11-26 2022-08-16 Disarm Therapeutics Inc Métodos e composições para neuroproteção
JP7477642B2 (ja) * 2020-04-09 2024-05-01 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤
ES3049432T3 (en) 2020-04-09 2025-12-16 Disarm Therapeutics Inc Indazole derivatives as inhibitors of sarm1
TWI786777B (zh) * 2020-08-24 2022-12-11 美商達薩瑪治療公司 Sarm1之抑制劑
WO2024100421A1 (en) * 2022-11-12 2024-05-16 Cambridge Enterprise Limited Sarm1 inhibitors for use in therapy and cosmetics
WO2024222835A1 (en) * 2023-04-27 2024-10-31 Sironax Ltd. Sarm1 modulators, preparations, and uses thereof
CN116836162B (zh) * 2023-05-24 2025-09-05 南方医科大学 吡唑[4,3-c]吡啶类化合物或其药学上可接受的盐及其应用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080153828A1 (en) 2005-04-05 2008-06-26 Elizabeth Aaron Collins Imidazopyridazine Compounds
WO2009041567A1 (ja) 2007-09-27 2009-04-02 Banyu Pharmaceutical Co., Ltd. メラニン凝集ホルモン受容体拮抗作用を有するジアリールケチミン誘導体
JP2011530500A (ja) 2008-08-06 2011-12-22 ファイザー・インク Ｃｈｋ−１阻害剤としての６置換２−ヘテロシクリルアミノピラジン化合物
WO2012106343A2 (en) 2011-02-01 2012-08-09 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
JP2013519681A (ja) 2010-02-11 2013-05-30 オーエスアイ・ファーマシューティカルズ，エルエルシー ７−アミノフロピリジン誘導体
JP2014509313A (ja) 2011-02-01 2014-04-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ７−アザインドール誘導体
WO2014198848A2 (en) 2013-06-12 2014-12-18 Lytix Biopharma As Compounds
WO2018011628A1 (en) 2016-07-11 2018-01-18 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2018071794A1 (en) 2016-10-14 2018-04-19 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ209833A (en) 1983-10-17 1988-04-29 Lilly Co Eli 3-bicyclicpyridiniummethyl-cephalosporins and pharmaceutical compositions
US5468757A (en) * 1994-01-31 1995-11-21 Eli Lilly And Company 6-azaindole thromboxane synthase inhibitors
AU747776B2 (en) * 1998-10-30 2002-05-23 Merck & Co., Inc. Thrombin inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
KR100865262B1 (ko) 2001-04-11 2008-10-24 센주 세이야꾸 가부시키가이샤 시각 기능 장애 개선제
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
NZ531786A (en) 2001-10-02 2006-10-27 Upjohn Co Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
CN1312154C (zh) 2002-03-05 2007-04-25 伊莱利利公司 作为激酶抑制剂的嘌呤衍生物
IL164209A0 (en) 2002-05-31 2005-12-18 Eisai Co Ltd Pyrazole derivatives and pharmaceutical compositions containing the same
AU2003269413A1 (en) 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
MXPA05004723A (es) 2002-11-01 2005-12-05 Pharmacia & Upjohn Co Llc Compuestos que tienen ambas actividades del agonista alfa 7 nachr y el antagonista 5ht para el tratamiento de las enfermedades del snc.
EA200500783A1 (ru) 2002-12-11 2005-12-29 ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи Комбинация для лечения синдрома дефицита внимания с гиперактивностью
JP2006510662A (ja) 2002-12-11 2006-03-30 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー α７ニコチン性アセチルコリン受容体アゴニストとその他の化合物との組合せによる疾患の治療
CN1764456A (zh) 2003-01-22 2006-04-26 法马西亚和厄普乔恩公司 利用α－7nACh受体完全激动剂对相关疾病的治疗
EP1706384A1 (en) 2004-01-07 2006-10-04 AstraZeneca AB Therapeutic agents i
AU2005263762C1 (en) 2004-07-21 2012-03-01 Merck Serono Sa Octahydropyrrolo[2, 3, c]pyridine derivatives and pharmaceutical use thereof
KR100958830B1 (ko) 2004-09-03 2010-05-24 주식회사유한양행 피롤로[2,3-ｃ]피리딘 유도체 및 그의 제조방법
EP1819697B1 (en) 2004-12-08 2012-08-01 Johannes Gutenberg-Universität Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
EA017278B9 (ru) 2005-06-22 2013-01-30 Кемосентрикс, Инк. Соединения азаиндазола и способы применения
US7777035B2 (en) 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
KR101142363B1 (ko) 2005-06-27 2012-05-21 주식회사유한양행 피롤로피리딘 유도체를 포함하는 항암제 조성물
CN101003537A (zh) 2006-01-17 2007-07-25 上海恒瑞医药有限公司 吡咯并哒嗪类衍生物及其制备方法和用途
GB0705803D0 (en) 2007-03-28 2007-05-02 Glaxo Group Ltd Novel compounds
PE20090552A1 (es) 2007-03-30 2009-06-01 Sanofi Aventis Compuestos de pirimidina hidrazida como inhibidores de pgds
AU2008241488A1 (en) 2007-04-16 2008-10-30 Merck Sharp & Dohme Corp. Bicyclic anilide heterocyclic CGRP receptor antagonists
GB0803018D0 (en) 2008-02-19 2008-03-26 Cancer Rec Tech Ltd Therapeutic compounds and their use
WO2009120717A2 (en) 2008-03-24 2009-10-01 Medivation Technologies, Inc. Pyrido [3, 4-b] indoles and methods of use
CL2009001152A1 (es) 2008-05-13 2009-10-16 Array Biopharma Inc Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa.
US8012992B2 (en) 2008-06-30 2011-09-06 Allergan, Inc. Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
ES2459047T3 (es) 2008-08-05 2014-05-07 Daiichi Sankyo Company, Limited Derivados de imidazopiridin-2-ona
WO2010042337A1 (en) 2008-10-07 2010-04-15 Merck Sharp & Dohme Corp. Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
EP2340243B1 (en) 2008-10-17 2014-10-08 Boehringer Ingelheim International GmbH Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
CN101723936B (zh) 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
MX2011005011A (es) 2008-11-14 2011-07-29 Merial Ltd Compuestos de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, metodo de elaboracion y de uso de los mismos.
WO2011096490A1 (ja) 2010-02-04 2011-08-11 第一三共株式会社 イミダゾピリジン－２－オン誘導体
JP2011178779A (ja) 2010-02-04 2011-09-15 Daiichi Sankyo Co Ltd イミダゾピリジン−２−オン誘導体
GB201017345D0 (en) 2010-10-14 2010-11-24 Proximagen Ltd Receptor antagonists
US9273028B2 (en) 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
PE20140471A1 (es) 2011-01-04 2014-04-13 Novartis Ag Moduladores de la via del complemento y usos de los mismos
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
AP2013007159A0 (en) 2011-04-05 2013-10-31 Pfizer Ltd Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of tropomyosin-related kinase
US20120328629A1 (en) 2011-06-24 2012-12-27 University Of Miami Therapeutic Applications Targeting SARM1
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
TWI577671B (zh) 2011-11-14 2017-04-11 Sunshine Lake Pharma Co Ltd Aminoquinazoline derivatives and salts thereof and methods of use thereof
CN102532027A (zh) 2012-03-01 2012-07-04 常州协丰医药研发有限公司 一种通过羟胺活化来形成吲唑衍生物的合成方法
CN102675310B (zh) 2012-05-09 2014-12-24 林辉 制备吡唑并芳杂环化合物的方法
US20150336948A1 (en) 2012-05-29 2015-11-26 Merck Sharp & Dohme Corp. Isotopically Labeled Biaryl Urea Compounds
US9388199B2 (en) 2012-06-28 2016-07-12 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
ES2648962T3 (es) 2012-06-28 2018-01-09 Novartis Ag Derivados de pirrolidina y su uso como moduladores de la vía del complemento
MX2015000537A (es) 2012-07-12 2015-05-11 Novartis Ag Moduladores de la senda del complemento y usos de los mismos.
US9127003B2 (en) 2012-07-26 2015-09-08 Glaxo Group Limited 2-(azaindol-2-yl)benzimidazoles as PAD4 inhibitors
HK1218909A1 (zh) 2013-03-12 2017-03-17 Abbvie Inc. 二氢-吡咯并吡啶酮布罗莫结构域抑制剂
TWI663166B (zh) 2013-04-24 2019-06-21 健生藥品公司 新化合物
UA111696C2 (uk) 2013-05-02 2016-05-25 Пфайзер Інк. Похідні імідазотриазину як інгібітори рde10
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106456604B (zh) * 2014-02-25 2020-11-06 艾其林医药公司 用于治疗补体介导疾病的芳基、杂芳基和杂环化合物
US9856264B2 (en) 2014-04-28 2018-01-02 Medshine Discovery Inc. Isoquinolinesulfonyl derivative as RHO kinase inhibitor
WO2015191401A1 (en) 2014-06-13 2015-12-17 Bristol-Myers Squibb Company Tricyclic compounds as alpha- 7 nicotinic acetylcholine receptor ligands
WO2015188368A1 (en) 2014-06-13 2015-12-17 Merck Sharp & Dohme Corp. Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
ES2666794T3 (es) 2014-06-13 2018-05-07 Bristol-Myers Squibb Company Compuestos tricíclicos como ligandos del receptor de alfa-7 nicotínico de acetilcolina
CN107108662B9 (zh) 2014-08-06 2020-05-15 加州理工学院 芳族杂环通过地球丰富的无过渡金属的催化剂的甲硅烷基化
EP3209663B1 (en) 2014-10-23 2018-12-12 Janssen Pharmaceutica N.V. New pyrazolopyrimidine derivatives as nik inhibitors
ES2718557T3 (es) 2014-10-23 2019-07-02 Janssen Pharmaceutica Nv Nuevos compuestos como inhibidores de nik
WO2016095088A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
WO2016095089A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
US9938276B2 (en) 2014-12-19 2018-04-10 Merck Sharp & Dohme Corp. 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
WO2016161571A1 (en) 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. Indazole and azaindazole btk inhibitors
CA2979302A1 (en) 2015-05-13 2016-11-17 Selvita S.A. Substituted quinoxaline derivatives
CA2988436A1 (en) 2015-07-13 2017-01-19 Arvinas, Inc. Alanine-based modulators of proteolysis and associated methods of use
EP3331886B1 (en) 2015-08-05 2020-07-15 Indivior UK Limited Dopamine d3 receptor antagonists having a bicyclo moiety
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR105809A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos médicos
US11370792B2 (en) 2015-12-14 2022-06-28 Raze Therapeutics, Inc. Caffeine inhibitors of MTHFD2 and uses thereof
WO2017120429A1 (en) 2016-01-07 2017-07-13 CS Pharmasciences, Inc. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase
TWI854164B (zh) 2016-02-01 2024-09-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
ES2788348T3 (es) 2016-05-24 2020-10-21 Merck Patent Gmbh Derivados heterocíclicos tricíclicos
US20170355708A1 (en) 2016-06-09 2017-12-14 Cadent Therapeutics, Inc. Potassium channel modulators
US11357800B2 (en) 2016-08-16 2022-06-14 Henry Ford Health System Compositions for the treatment of neuropathic pain and sensitization of tumors to chemotherapies
CN109923114B (zh) 2016-09-09 2022-11-01 因赛特公司 作为hpk1调节剂的吡唑并吡啶衍生物和其用于治疗癌症的用途
JP7044789B2 (ja) 2016-09-24 2022-03-30 ワシントン・ユニバーシティ Ｓａｒｍ１ ｎａｄアーゼ活性の阻害剤およびその使用
SG11201903892UA (en) 2016-11-02 2019-05-30 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
WO2018149986A1 (en) 2017-02-16 2018-08-23 Oryzon Genomics, S.A. 2-(bicyclo-heteroaryl)-isonicotinic derivatives as histone demethylase inhibitors
WO2018170165A1 (en) 2017-03-15 2018-09-20 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
CA3055990A1 (en) 2017-03-15 2018-09-20 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
US20200131129A1 (en) 2017-03-15 2020-04-30 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2018210229A1 (zh) 2017-05-18 2018-11-22 南京明德新药研发股份有限公司 α-7尼古丁乙酰胆碱受体激动剂及应用
US11447505B1 (en) 2017-08-18 2022-09-20 Cancer Research Technology Limited Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
WO2019106087A1 (en) 2017-11-29 2019-06-06 Syddansk Universitet Ampk inhibitors
CN111727189B (zh) 2017-12-01 2023-10-03 伊利诺伊大学董事会 基于吡啶酮的表观遗传修饰剂及其用途
BR112020010534A2 (pt) 2017-12-05 2020-10-20 Oryzon Genomics, S.A. derivados de 1,2,4-oxadiazol como inibidores de histona desacetilase 6
KR20200121823A (ko) 2018-02-16 2020-10-26 유씨비 바이오파마 에스알엘 약학적 6,5 헤테로비시클릭 고리 유도체
UY38144A (es) 2018-03-12 2019-10-31 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa
US12103926B2 (en) 2018-03-27 2024-10-01 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
JP2019182784A (ja) 2018-04-10 2019-10-24 大日本住友製薬株式会社 ジヒドロピラゾロピラジノン誘導体
JP7307747B2 (ja) 2018-04-11 2023-07-12 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤としての４－オキソ－３，４－ジヒドロキナゾリン化合物
US11882759B2 (en) 2018-04-13 2024-01-23 Universal Display Corporation Organic electroluminescent materials and devices
WO2019214681A1 (en) 2018-05-09 2019-11-14 Aprinoia Therapeutics Inc. Heteroaryl compounds and uses thereof
WO2019236890A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
JP2021527125A (ja) 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドＤｉｓａｒｍ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｓａｒｍ１阻害剤
BR112021002408A2 (pt) 2018-08-09 2021-05-04 Valo Early Discovery, Inc. carboxamidas como inibidores da protease específica de ubiquitina

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080153828A1 (en) 2005-04-05 2008-06-26 Elizabeth Aaron Collins Imidazopyridazine Compounds
WO2009041567A1 (ja) 2007-09-27 2009-04-02 Banyu Pharmaceutical Co., Ltd. メラニン凝集ホルモン受容体拮抗作用を有するジアリールケチミン誘導体
JP2011530500A (ja) 2008-08-06 2011-12-22 ファイザー・インク Ｃｈｋ−１阻害剤としての６置換２−ヘテロシクリルアミノピラジン化合物
JP2013519681A (ja) 2010-02-11 2013-05-30 オーエスアイ・ファーマシューティカルズ，エルエルシー ７−アミノフロピリジン誘導体
WO2012106343A2 (en) 2011-02-01 2012-08-09 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
JP2014509313A (ja) 2011-02-01 2014-04-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ７−アザインドール誘導体
WO2014198848A2 (en) 2013-06-12 2014-12-18 Lytix Biopharma As Compounds
WO2018011628A1 (en) 2016-07-11 2018-01-18 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2018071794A1 (en) 2016-10-14 2018-04-19 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Fisher, M. H. et al.，Azaindole anthelmintic agents，Journal of Medicinal Chemistry，1972年，Vol.15, No.11，pp.1168-1171
Gallou, Fet al.，Practical regioselective bromination of azaindoles and diazaindoles，Synlett，2007年，No.2，pp.211-214
REGISTRY[online]，2009.10.27-2012.7.23, [Retrieved on 2023.5.19], Retrieved from：STN, CAS登録番号 1190318-02-5、1384079-12-2

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