JP7471218B2 - 洗浄、消毒および/または滅菌のための組成物、方法および使用 - Google Patents
洗浄、消毒および/または滅菌のための組成物、方法および使用 Download PDFInfo
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- JP7471218B2 JP7471218B2 JP2020521481A JP2020521481A JP7471218B2 JP 7471218 B2 JP7471218 B2 JP 7471218B2 JP 2020521481 A JP2020521481 A JP 2020521481A JP 2020521481 A JP2020521481 A JP 2020521481A JP 7471218 B2 JP7471218 B2 JP 7471218B2
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- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 229940035023 sucrose monostearate Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 description 1
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- HWCKGOZZJDHMNC-UHFFFAOYSA-M tetraethylammonium bromide Chemical compound [Br-].CC[N+](CC)(CC)CC HWCKGOZZJDHMNC-UHFFFAOYSA-M 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Secondary Cells (AREA)
- Toxicology (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
R5およびR6は、それぞれ独立して、結合、H、C、NH、NH2、C1-10アルキル、C1-10アルカン、C1-10アルキン、5または6つ炭素芳香環であり得、任意選択で、ハロゲンで置換されていてもよく;nは、1~5である)を含む。ハロゲンは、F、Br、Cl、I、およびAtである。ビグアニド含有化合物の非限定的な例として、ポリヘキサメチレンビグアニド(PHMB)、ポリアミノプロピルビグアニド(PAPB)、1,1’-(1,6-ヘキサンジイル)ビス{2-[N’-(2-エチルヘキシル)カルバムイミドイル]グアニジン}(アレキシジン)、クロルヘキシジン、およびクロルヘキシジングルコナートが挙げられる。
R7およびR8は、それぞれ独立して、それぞれ独立して、結合、H、C、NH、NH2、C1-10アルキル、C1-10アルカン、C1-10アルキン、5または6つ炭素芳香環であり得、任意選択で、ハロゲンで置換されていてもよく、nは、1~5である)を含む。ハロゲンは、F、Br、Cl、I、およびAtである。
(式中R9およびR10は、それぞれ独立して、結合、H、C、NH、NH2、C1-10アルキル、C1-10アルカン、C1-10アルキン、5または6つ炭素芳香環であり得、任意選択で、ハロゲンで置換されていてもよく、nは、1~5である)を含む。ハロゲンは、F、Br、Cl、I、およびAtである。
(式中、R1基は、H、C1-6アルキル、C1-6アルカン、C1-6アルキン、C3-6環状アルキル、またはC3-6アリールであり得る)の化合物である。
アルデヒドの非限定的な例として、ホルムアルデヒド、アセトアルデヒド、プロピオンアルデヒド、およびブチルアルデヒドが挙げられる。
(式中、R2基は、結合、C1-6アルキル、C1-6アルカン、C1-6アルキン、C3-6環状アルキル、またはC3-6アリールであり得る)の化合物である。
ジアルデヒドの非限定的な例として、オキサアルデヒド(oxaldehyde)、マロンジアルデヒド、グルタルアルデヒド、コハク酸ジアルデヒド(succinicdialdehyde)、フタルアルデヒド(オルト-フタルアルデヒド)、イソフタルアルデヒド(メタ-フタルアルデヒド)、およびテレフタルアルデヒド(パラ-フタルアルデヒド)が挙げられる。
(式中、
R3およびR4は、それぞれ独立して、H、C1-6アルキル、C1-6アルカン、C1-6アルキン、C3-6環状アルキル、またはC3-6アリールであり得る)
の化合物である。
有機ペルオキシドの非限定的な例として、ベンゾイルペルオキシドおよびエタンペルオキソ酸(過酢酸)が挙げられる。
以下の非限定的な実施例は、ここで企図される代表的な実施形態のより完全な理解を容易にするため、例示のみの目的のために提供される。これら実施例は、本明細書中開示される組成物、方法、および使用に関連するものを含み、本明細書に記載される実施形態のいずれをも限定するように解釈すべきではない。
組成物
この実施例は、本明細書中開示される組成物を製剤化する方法を説明する。以下に列挙される成分を、混合物が均一になるまで、高せん断混合器を使用して周囲温度で混合した。混合物のpHは、示すように調節した。次亜塩素酸の量に関して、他の記載がない限り、この量は、他の成分と混合した後の最終濃度である。
枯草菌(バチルス・サブティリス(Bacillus subtilis))を使用した芽胞のバイアビリティのアッセイ
この実施例は、本明細書中開示される組成物を使用した芽胞のバイアビリティのアッセイを行う方法を説明する。
枯草菌(Bacillus subtilis)を使用した芽胞のバイアビリティのアッセイ
この実施例は、本明細書中開示される組成物を使用した芽胞のバイアビリティのアッセイを行う方法を説明する。
安定性の実験
この実施例は、本明細書中開示される組成物を使用した組成物の安定性の試験を行う方法を説明する。
クロストリジウム・ディフィシル(Clostridium difficile)を使用した細菌のバイアビリティのアッセイ
この実施例は、本明細書中開示される組成物を使用した組成物の安定性の試験を行う方法を説明する。
医療機器の消毒
病原体の芽胞の懸濁液のストックは、実施例2に記載のように調製した。
Claims (25)
- 組成物の8重量%~12重量%のポリヘキサメチレンビグアニド(PHMB)と、
組成物の40重量%~70重量%のイソプロパノールと、
水と、
を含む組成物であって、
前記組成物は、非イオン性界面活性剤を含まない、
組成物。 - 2%~10%の1つ以上の四級アンモニウム界面活性剤をさらに含み、前記1つ以上の四級アンモニウム界面活性剤はセチルピリジニウムクロリドを含む、請求項1に記載の組成物。
- 組成物の8重量%~12重量%のポリヘキサメチレンビグアニド(PHMB)と、
組成物の40重量%~60重量%のイソプロパノールと、
2%~7%のセチルピリジニウムクロリドと、
を含む、請求項2に記載の組成物。 - 組成物の4重量%~8重量%のポリヘキサメチレンビグアニド(PHMB)と、
組成物の40重量%~60重量%のイソプロパノールと、
2%~7%のセチルピリジニウムクロリドと、
水と、
を含む組成物であって、
前記組成物は、非イオン性界面活性剤を含まない、
組成物。 - 1つ以上の担体または1つ以上の追加的な成分をさらに含む、請求項1~4のいずれか1項に記載の組成物。
- 請求項1~5のいずれか1項に記載の組成物を含む、キットであって、1つ以上のグアニド含有化合物を含む第1の構成要素と、1つ以上のアルコールを含む第2の構成要素と、を含むキット。
- 1つ以上の送達システムもしくは適用システム、および/または説明書、および/または容器をさらに含む、請求項6に記載のキットであって、1つ以上の四級アンモニウム界面活性剤を含む第3の構成要素、および/またはすすぎ溶液を含む第4の構成要素、および/または1つ以上の送達システムもしくは適用システム、および/または説明書、および/または容器を含んでもよい、キット。
- 装置を洗浄、消毒、および/または滅菌するための方法であって、装置に、請求項1~5のいずれか1項に記載の組成物を適用するステップを含み、前記組成物の適用が、前記装置を洗浄、消毒、および/または滅菌する、方法。
- 装置の洗浄、消毒、および/または滅菌に使用するための、請求項1~5のいずれか1項に記載の組成物。
- 装置を洗浄、消毒、および/または滅菌するための、請求項1~5のいずれか1項に記載の組成物の使用。
- 表面領域を洗浄、消毒、および/または滅菌するための方法であって、装置に、請求項1~5のいずれか1項に記載の組成物を適用するステップを含み、前記組成物の適用が、前記装置を洗浄、消毒、および/または滅菌する、方法。
- 前記表面領域が、多孔性の表面領域または非孔性の表面領域である、請求項11に記載の方法。
- 前記表面領域が、テーブルの上面、カウンターの上面、床、壁、天井、窓、ドア、ドアのハンドル、シャワー、浴室、シンク、蛇口、トイレ、便座、配水管、設備、機械、防具、個人のバイオハザード防護服、医療機器、歯科用機器、医薬用機器、獣医学用機器、または葬儀用機器を含む、請求項11または12に記載の方法。
- 前記医療機器が、外科用器具、呼吸療法器具、麻酔器具、カテーテル、インプラント、プローブ、内視鏡、関節鏡、腹腔鏡、ブレード、膀胱鏡、スパイロメーター、CPAP用のマスクおよびチューブ、透析の器具およびアクセサリ、人工心肺装置およびアクセサリ、心肺バイパス装置およびアクセサリ、および避妊具適合リングである、請求項13に記載の方法。
- 表面領域の洗浄、消毒、および/または滅菌に使用するための、請求項1~5のいずれか1項に記載の組成物。
- 前記表面領域が、多孔性の表面領域または非孔性の表面領域である、請求項15に記載の組成物。
- 前記表面領域が、テーブルの上面、カウンターの上面、床、壁、天井、窓、ドア、ドアのハンドル、シャワー、浴室、シンク、蛇口、トイレ、便座、配水管、設備、機械、防具、個人のバイオハザード防護服、医療機器、歯科用機器、医薬用機器、獣医学用機器、または葬儀用機器を含む、請求項15または16に記載の組成物。
- 前記医療機器が、外科用器具、呼吸療法器具、麻酔器具、カテーテル、インプラント、プローブ、内視鏡、関節鏡、腹腔鏡、ブレード、膀胱鏡、スパイロメーター、CPAP用のマスクおよびチューブ、透析の器具およびアクセサリ、人工心肺装置およびアクセサリ、心肺バイパス装置およびアクセサリ、および避妊具適合リングである、請求項17に記載の組成物。
- ヒトを除く表面領域を洗浄、消毒、および/または滅菌するための、請求項1~5のいずれか1項に記載の組成物の使用。
- 前記表面領域が、多孔性の表面領域または非孔性の表面領域である、請求項19に記載の使用。
- 前記表面領域が、テーブルの上面、カウンターの上面、床、壁、天井、窓、ドア、ドアのハンドル、シャワー、浴室、シンク、蛇口、トイレ、便座、配水管、設備、機械、防具、個人のバイオハザード防護服、医療機器、歯科用機器、医薬用機器、獣医学用機器、または葬儀用機器を含む、請求項19または20に記載の使用。
- 前記医療機器が、外科用器具、呼吸療法器具、麻酔器具、カテーテル、インプラント、プローブ、内視鏡、関節鏡、腹腔鏡、ブレード、膀胱鏡、スパイロメーター、CPAP用のマスクおよびチューブ、透析の器具およびアクセサリ、人工心肺装置およびアクセサリ、心肺バイパス装置およびアクセサリ、および避妊具適合リングである、請求項21に記載の使用。
- 組成物の適用が局所的に適用される、個体における微生物感染の洗浄、消毒、および/または滅菌に使用するための、請求項1~5のいずれか1項に記載の組成物。
- 個体における微生物感染を洗浄、消毒、および/または滅菌するための医薬の製造における、請求項1~5のいずれか1項に記載の組成物の使用。
- 前記組成物が、局所的に適用されるか、または腸内もしくは非経口的に投与される、請求項24に記載の使用。
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Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102013011752A1 (de) * | 2013-07-13 | 2015-01-15 | Manfred Völker | Chlormessung / Filterprüfung / Solebehälterüberwachung einer Wasseraufbereitungsanlage |
AU2018294246A1 (en) | 2017-06-28 | 2020-02-13 | Collidion, Inc. | Compositions, methods and uses for cleaning, disinfecting and/or sterilizing |
US10849999B2 (en) * | 2017-10-25 | 2020-12-01 | Michael Overmyer | Method for disinfecting pressurized assisted breathing machines and maintaining said machine's air quality |
MX2020007533A (es) | 2018-01-14 | 2021-01-15 | Collidion Inc | Composiciones, equipos, metodos y usos para la limpieza, desinfeccion, esterilizacion y/o tratamiento. |
GB201902731D0 (en) | 2019-02-28 | 2019-04-17 | Clinical Health Tech Ltd | Stabilised hypochlorous solutions and their medical use |
AU2020291943A1 (en) | 2019-06-14 | 2022-02-10 | Collidion, Inc. | Compositions, kits, methods and uses for preventing microbial growth |
CN110464679B (zh) * | 2019-09-06 | 2022-06-14 | 广州一一生物技术有限公司 | 一种搓泥宝及其制备方法 |
ES2830898B2 (es) | 2020-04-25 | 2022-12-29 | Bio Logic Crop Science S L | Limpiador y germicida en aerosol de tiempo de actuación prolongado |
JP7345886B2 (ja) * | 2020-05-25 | 2023-09-19 | 株式会社東洋新薬 | アルコール含有組成物 |
CN111690469B (zh) * | 2020-07-08 | 2022-03-11 | 青岛拜士特新材料有限公司 | 一种含有吡啶硫酮锌抗菌剂的除菌洗衣粉及其制备方法 |
CN111733027B (zh) * | 2020-07-08 | 2022-03-11 | 青岛拜士特新材料有限公司 | 一种速溶型洗涤用抗菌母粒及制备方法 |
CN111733021B (zh) * | 2020-07-08 | 2022-03-29 | 青岛拜士特新材料有限公司 | 一种含有pcmx的除菌洗衣粉及其制备方法 |
CN111793530A (zh) * | 2020-08-14 | 2020-10-20 | 苏州卫生职业技术学院 | 一种高性能安全环保的无托槽隐形矫治器用泡沫清洁剂及制备方法 |
JP6908233B1 (ja) * | 2020-08-17 | 2021-07-21 | 株式会社イースト | 除菌剤及び除菌剤の製造方法 |
KR102216113B1 (ko) * | 2020-11-05 | 2021-02-16 | 주식회사 강남바이오프라자 | 세정 기능을 겸비한 소독용 거즈 |
ES2911975A1 (es) * | 2020-11-20 | 2022-05-23 | Brill Engines S L | Un producto para la limpieza de la piel sana |
KR102284870B1 (ko) * | 2020-12-11 | 2021-08-03 | 고자임 | 살균면적이 향상된 살균소독제와 그 제조방법 |
KR102275781B1 (ko) * | 2020-12-23 | 2021-07-09 | 주식회사 비바케어 | 표면 살균 및 소독용 조성물 및 그 제조방법 |
KR102514068B1 (ko) * | 2021-02-10 | 2023-03-24 | 강원대학교산학협력단 | 미산성 차아염소산수를 포함하는 친환경 나노에멀션 손소독제 조성물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524475A (ja) | 1998-09-11 | 2002-08-06 | サーファシン ディベロップメント カンパニー, エルエルシー | 局所経皮抗菌組成物 |
JP2009528360A (ja) | 2006-02-28 | 2009-08-06 | ベクトン・ディキンソン・アンド・カンパニー | 抗菌性組成物及び固定型カテーテルのための方法 |
JP5068408B2 (ja) | 1999-12-13 | 2012-11-07 | エシコン・インコーポレイテッド | 深部浸透性抗菌剤組成物 |
JP2017515886A (ja) | 2014-03-28 | 2017-06-15 | ガーマ ヘルスケア リミテッドGama Healthcare Ltd | 液体抗菌組成物 |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2140401A (en) | 1935-12-20 | 1938-12-13 | Nat Aluminate Corp | Process of treating water |
US3914397A (en) | 1970-08-05 | 1975-10-21 | Pulp Paper Res Inst | Production of chlorine monoxide gas |
US4190638A (en) | 1978-06-07 | 1980-02-26 | Ppg Industries, Inc. | Production of hypochlorous acid |
JPS5761099A (en) | 1980-09-30 | 1982-04-13 | Lion Corp | Liquid sterilizing beaching agent composition |
US4394517A (en) | 1982-05-21 | 1983-07-19 | Sws Silicones Corporation | Quaternary ammonium functional silicon compounds |
GB2122900A (en) * | 1982-07-01 | 1984-01-25 | Surgikos Inc | Disinfectant compositions having residual biocidal activity and wipes and sprays containing them |
GB8312663D0 (en) | 1983-05-09 | 1983-06-15 | Ici Plc | Bisbiguanide compounds |
GB8314500D0 (en) | 1983-05-25 | 1983-06-29 | Procter & Gamble Ltd | Cleaning compositions |
US4908215A (en) | 1986-03-06 | 1990-03-13 | Brandeis University | Hypochlorite compositions containing thiosulfate and use thereof |
US5019173A (en) | 1988-09-29 | 1991-05-28 | Dow Corning Corporation | Cleaning method for water containing vessels and systems |
US5098970A (en) | 1990-10-31 | 1992-03-24 | Phillips Petroleum Company | Superabsorbent crosslinked ampholytic ion pair copolymers |
EP0602081A4 (en) | 1991-09-04 | 1995-03-22 | Olin Corp | PROCESS FOR PRODUCING CONCENTRATED HYPOCHLOROUS ACID SOLUTIONS. |
JP2533723B2 (ja) * | 1992-12-28 | 1996-09-11 | 東興薬品工業株式会社 | 速乾性ゲルタイプ手指消毒剤 |
US6207201B1 (en) | 1993-06-03 | 2001-03-27 | Amuchina International, Inc. | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
US5332511A (en) | 1993-06-25 | 1994-07-26 | Olin Corporation | Process of sanitizing swimming pools, spas and, hot tubs |
US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
GB9322132D0 (en) | 1993-10-27 | 1993-12-15 | Zeneca Ltd | Antimicrobial treatment of textile materials |
US5368749A (en) | 1994-05-16 | 1994-11-29 | Nalco Chemical Company | Synergistic activity of glutaraldehyde in the presence of oxidants |
GB9506841D0 (en) * | 1995-04-03 | 1995-05-24 | Unilever Plc | Deodorant compositions |
EP0844827B1 (en) | 1995-08-15 | 1999-06-09 | S.C. Johnson Commercial Markets, Inc. | Tuberculocidal synergistic disinfectant compositions and methods of disinfecting |
US6503952B2 (en) * | 1995-11-13 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Triple antimicrobial composition |
FR2745497B1 (fr) * | 1996-02-29 | 2002-09-06 | Anios Lab Sarl | Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection |
NO311696B1 (no) | 1997-01-24 | 2002-01-07 | Norske Stats Oljeselskap | Fremgangsmåte og integrert prosessanlegg for fremstilling av synfuel og el-kraft |
ES2327369T3 (es) * | 1998-02-12 | 2009-10-28 | Surfacine Development Company, Llc | Compuestos desinfectantes que proporcionan accion biocida prolongada. |
US6132625A (en) | 1998-05-28 | 2000-10-17 | E. I. Du Pont De Nemours And Company | Method for treatment of aqueous streams comprising biosolids |
US6455086B1 (en) | 1998-06-26 | 2002-09-24 | The Procter & Gamble Company | Microorganism reduction methods and compositions for food cleaning |
AU4680800A (en) | 1999-04-29 | 2000-11-17 | Henceforth Hibernia, Inc. | Biomimetic water solutions and compositions, their use as and in health and beauty care products and the methods to prepare them |
US6333054B1 (en) | 1999-10-21 | 2001-12-25 | Amuchina S.P.A. | Topical, non-cytotoxic, antimicrobial hydrogel with thixotropic properties |
US6426066B1 (en) | 2000-01-12 | 2002-07-30 | California Pacific Labs, Inc. | Use of physiologically balanced, ionized, acidic solution in wound healing |
US20030109411A1 (en) * | 2001-08-24 | 2003-06-12 | The Clorox Company, A Delaware Corporation | Bactericidal cleaning wipe |
US20020197299A1 (en) | 2000-12-21 | 2002-12-26 | Vanderlaan Douglas G. | Antimicrobial contact lenses containing activated silver and methods for their production |
DE60111430T2 (de) | 2001-10-01 | 2006-05-11 | Aquilabs S.A. | Hypochlorige säurezusammensetzung und ihre verwendungen |
US6846846B2 (en) * | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
US7238278B2 (en) | 2001-10-26 | 2007-07-03 | Zodiac Pool Care, Inc. | Apparatus for purifying water |
ES2377945T3 (es) | 2001-12-05 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Método y aparato para producir agua con potencial de oxidación y reducción (ORP) negativo y positivo |
US20050239675A1 (en) | 2002-04-01 | 2005-10-27 | Munzer Makansi | Carrier foam to enhance liquid functional performance |
GB0209134D0 (en) | 2002-04-22 | 2002-05-29 | Procter & Gamble | Silicones |
US20060231505A1 (en) | 2002-08-22 | 2006-10-19 | Mayer Michael J | Synergistic biocidal mixtures |
US7008545B2 (en) | 2002-08-22 | 2006-03-07 | Hercules Incorporated | Synergistic biocidal mixtures |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US20060193789A1 (en) | 2002-10-25 | 2006-08-31 | Foamix Ltd. | Film forming foamable composition |
EP1603389A1 (en) * | 2003-03-10 | 2005-12-14 | Xantech Pharmaceuticals, Inc. | Surface sanitizing compositions with improved antimicrobial performance |
US9168318B2 (en) | 2003-12-30 | 2015-10-27 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and methods of using the same |
US20050139808A1 (en) | 2003-12-30 | 2005-06-30 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and process for producing same |
CA2560830A1 (en) | 2004-03-23 | 2005-10-13 | The Clorox Company | Method for diluting hypochlorite |
US7718122B2 (en) | 2004-04-20 | 2010-05-18 | The Clorox Company | Carriers for hypochlorous acid vapor |
GB0414244D0 (en) * | 2004-06-25 | 2004-07-28 | Ebiox Ltd | Composition |
US20060003023A1 (en) | 2004-07-02 | 2006-01-05 | Williams Terry M | Microbicidal composition |
JP4526023B2 (ja) | 2004-12-24 | 2010-08-18 | 信越化学工業株式会社 | 農業用殺菌剤組成物 |
US20060147549A1 (en) * | 2004-12-30 | 2006-07-06 | Grab Lawrence A | Methods and compositions for reducing population of plant pathogen |
ATE402247T1 (de) | 2005-02-16 | 2008-08-15 | Unilever Nv | Wässrige flüssigbleichmittel |
US9498548B2 (en) | 2005-05-02 | 2016-11-22 | Oculus Innovative Sciences, Inc. | Method of using oxidative reductive potential water solution in dental applications |
US7651990B2 (en) * | 2005-06-13 | 2010-01-26 | 3M Innovative Properties Company | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
US8088400B2 (en) * | 2005-08-22 | 2012-01-03 | Quick-Med Technologies, Inc. | Disinfectant with quarternary ammonium polymer and copolymers |
US8343523B2 (en) * | 2005-08-22 | 2013-01-01 | Quick-Med Technologies, Inc. | Disinfectant with durable activity based on alcohol-soluble quaternary ammonium polymers and copolymers |
US8147444B2 (en) | 2006-01-20 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
US20080014289A1 (en) | 2006-07-12 | 2008-01-17 | Jianping Li | Vehicle and method for treating and preventing acne vulgaris and exfoliating the skin hypohalous acids |
ZA200709364B (en) | 2006-11-14 | 2008-11-26 | Rohm & Haas | Microbicide combinations containing silver |
US8318654B2 (en) | 2006-11-30 | 2012-11-27 | Kimberly-Clark Worldwide, Inc. | Cleansing composition incorporating a biocide, heating agent and thermochromic substance |
CZ299143B6 (cs) | 2007-03-06 | 2008-04-30 | Ecoton S. R. O. | Dezinfekcní prostredek |
MX2009009760A (es) | 2007-03-13 | 2009-09-24 | Oculus Innovative Sciences Inc | Soluciones antimicrobiales que contienen monoxido de dicloro y metodos para hacer y utilizar las mismas. |
WO2009005936A1 (en) * | 2007-06-29 | 2009-01-08 | 3M Innovative Properties Company | Accelerating a ninhydrin reaction |
GB0713799D0 (en) * | 2007-07-17 | 2007-08-22 | Byotrol Llc | Anti-microbial compositions |
US20090148342A1 (en) | 2007-10-29 | 2009-06-11 | Bromberg Steven E | Hypochlorite Technology |
US7884089B2 (en) | 2008-02-08 | 2011-02-08 | Xurex, Inc. | Antimicrobial coating |
US8840911B2 (en) | 2008-03-07 | 2014-09-23 | Kimberly-Clark Worldwide, Inc. | Moisturizing hand sanitizer |
US8945630B2 (en) | 2008-04-11 | 2015-02-03 | Aquilabs S.A. | Method of producing and applications of composition of hypochlorous acid |
US7700530B2 (en) | 2008-06-30 | 2010-04-20 | Kimberly Clark Worldwide, Inc. | Polysensorial personal care cleanser comprising a quaternary silicone surfactant |
CA2765696C (en) | 2009-06-15 | 2018-03-06 | Oculus Innovative Sciences, Inc. | Solution containing hypochlorous acid and methods of using same |
MX2012000105A (es) * | 2009-06-30 | 2012-03-14 | Univ Columbia | Composiciones antimicrobianas/conservadoras que comprenden extractos botanicos. |
US20120121679A1 (en) * | 2009-07-16 | 2012-05-17 | University Of Georgia Research Foundation, Inc. | Viricidal and microbicidal compositions and uses thereof |
CN102596207B (zh) | 2009-07-30 | 2018-04-24 | 索诺马制药公司 | 包含氧化还原电位水的水凝胶配制剂 |
US20110052506A1 (en) | 2009-08-31 | 2011-03-03 | Collegium Pharmaceutical, Inc. | Stable Aerosol Topical Foams Comprising a Hypochlorite Salt |
US20110135702A1 (en) | 2009-12-09 | 2011-06-09 | Hoffman Douglas R | Sporicidal composition for clostridium difficile spores |
GB201000916D0 (en) | 2010-01-21 | 2010-03-10 | Adv Med Solutions Ltd | Treatment of biofilms |
GB2477717A (en) | 2010-02-03 | 2011-08-17 | Mauve Technology Ltd | Disinfectant materials and methods |
US20110236582A1 (en) | 2010-03-29 | 2011-09-29 | Scheuing David R | Polyelectrolyte Complexes |
EP2603193A4 (en) | 2010-08-10 | 2015-08-05 | Oreal | COSMETIC SILICONE COMPOSITIONS AND USES THEREOF |
US20120156307A1 (en) | 2010-12-16 | 2012-06-21 | Apr Nanotechnologies S.A. | Medical uses of nanoclustered water |
US20120223022A1 (en) | 2011-03-01 | 2012-09-06 | Molycorp Minerals, Llc | Contaminant removal from waters using rare earths |
US9381214B2 (en) | 2011-03-18 | 2016-07-05 | Puricore, Inc. | Methods for treating skin irritation |
PL2707549T3 (pl) * | 2011-05-13 | 2015-08-31 | Unilever Nv | Urządzenie rozpylające |
US20120301528A1 (en) | 2011-05-24 | 2012-11-29 | Uhlmann Donald R | Compositions and methods for antimicrobial metal nanoparticles |
WO2013051013A2 (en) | 2011-07-28 | 2013-04-11 | Tata Consultancy Services Limited | Water purification device |
GB201118673D0 (en) * | 2011-10-28 | 2011-12-14 | Byotrol Plc | Anti-microbial composition |
BR112014017530A8 (pt) | 2012-01-19 | 2017-07-04 | Procter & Gamble | métodos para alisamento de rugas e imperfeições da textura da pele |
CN103170004B (zh) | 2012-04-23 | 2016-08-31 | 佛山市优特医疗科技有限公司 | 一种制备含银纤维伤口敷料的方法 |
US20160024667A1 (en) | 2012-10-16 | 2016-01-28 | GenEon Technologies LLC | Electrochemical activation of water |
KR20150097560A (ko) | 2012-12-13 | 2015-08-26 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 식물성 항균 조성물 |
WO2014147643A2 (en) | 2013-03-19 | 2014-09-25 | Tata Consultancy Services Limited | Portable apparatus for treatment of water and method thereof |
JP6416227B2 (ja) | 2013-05-22 | 2018-10-31 | ソノマ ファーマシューティカルズ、インコーポレイテッド | 安定化次亜塩素酸溶液及びその使用 |
US10687536B2 (en) | 2013-06-27 | 2020-06-23 | Microlin, Llc | Disposable wipes for energized treatment agent |
WO2015002932A1 (en) | 2013-07-01 | 2015-01-08 | Puricoe, Inc. | Antimicrobial compositions comprising hypochlorous acid and silver |
US20160330969A1 (en) | 2013-10-23 | 2016-11-17 | John F. O'Connell, JR. | Antimicrobial compositions and articles |
US9597353B2 (en) | 2013-10-24 | 2017-03-21 | Reoxcyn Discoveries Group, Inc. | Redox signaling gel formulation |
US20150119245A1 (en) | 2013-10-25 | 2015-04-30 | EIJ Industries, Inc. | Method for Producing Shelf Stable Hypochlorous Acid Solutions |
US20150125543A1 (en) | 2013-11-07 | 2015-05-07 | Simple Science Limited | Gel disinfecting composition |
US11027032B2 (en) * | 2014-01-08 | 2021-06-08 | Carefusion 2200, Inc. | Systems, methods, and devices for sterilizing antiseptic solutions |
TW201538181A (zh) | 2014-03-19 | 2015-10-16 | Pures Biotech Co Ltd | 用於潤滑保濕消毒滅菌之半流體組成物及其使用方法 |
MX2016013198A (es) | 2014-04-30 | 2017-01-16 | Kimberly Clark Co | Uso del extracto de undaria para reducir los signos de envejecimiento de la piel. |
US9585820B2 (en) | 2014-05-20 | 2017-03-07 | Avon Products, Inc. | Laponite clay in cosmetic and personal care products |
EP3028568A1 (en) | 2014-12-05 | 2016-06-08 | Desinfeccion Profesional, S.L. | Biocidal composition with dual inmediate and remnant activity |
US9839602B2 (en) | 2014-12-16 | 2017-12-12 | Momentive Performance Materials Inc. | Personal care compositions containing crosslinked silicone polymer networks and their method of preparation |
US9801805B2 (en) | 2014-12-16 | 2017-10-31 | Momentive Performance Materials Inc. | Personal care composition comprising silicone network |
WO2016100543A2 (en) | 2014-12-16 | 2016-06-23 | Puricore, Inc. | Hypochlorous acid formulations and methods for treating skin conditions |
US9956151B2 (en) | 2015-03-05 | 2018-05-01 | Avon Products, Inc. | Methods for treating skin |
GB2541407A (en) | 2015-08-17 | 2017-02-22 | Xanadox Tech Ltd | Improvements relating to disinfectant solutions |
US10485827B2 (en) | 2016-01-19 | 2019-11-26 | Rdg Holdings, Inc. | Topical eye serum compositions, methods or preparing, and methods of use |
US20170290789A1 (en) | 2016-04-11 | 2017-10-12 | Frank DiCosmo | Wound irrigation solutions |
US9474768B1 (en) | 2016-05-18 | 2016-10-25 | Reoxcyn Discoveries Group, Inc. | Lubricant formulations |
US9833471B1 (en) | 2016-09-15 | 2017-12-05 | Reoxcyn Discoveries Group, Inc. | Hypochlorous acid-based hand sanitizer |
AU2018294246A1 (en) | 2017-06-28 | 2020-02-13 | Collidion, Inc. | Compositions, methods and uses for cleaning, disinfecting and/or sterilizing |
-
2018
- 2018-06-28 AU AU2018294246A patent/AU2018294246A1/en active Pending
- 2018-06-28 KR KR1020207002562A patent/KR20200034722A/ko not_active Application Discontinuation
- 2018-06-28 SG SG11201912534SA patent/SG11201912534SA/en unknown
- 2018-06-28 CN CN201880054035.XA patent/CN111032060A/zh active Pending
- 2018-06-28 US US16/022,673 patent/US10412968B2/en active Active
- 2018-06-28 MX MX2019015822A patent/MX2019015822A/es unknown
- 2018-06-28 EP EP18823261.5A patent/EP3645017A4/en active Pending
- 2018-06-28 WO PCT/US2018/040155 patent/WO2019006217A1/en unknown
- 2018-06-28 BR BR112019028093-6A patent/BR112019028093A2/pt unknown
- 2018-06-28 JP JP2020521481A patent/JP7471218B2/ja active Active
- 2018-06-28 CA CA3067855A patent/CA3067855A1/en active Pending
-
2019
- 2019-08-14 US US16/540,733 patent/US10750748B2/en active Active
- 2019-08-14 US US16/540,707 patent/US10750747B2/en active Active
- 2019-12-19 IL IL271623A patent/IL271623A/en unknown
-
2020
- 2020-01-27 ZA ZA2020/00532A patent/ZA202000532B/en unknown
- 2020-08-17 US US16/994,862 patent/US20200375189A1/en active Pending
- 2020-08-17 US US16/994,847 patent/US11974573B2/en active Active
-
2023
- 2023-07-12 JP JP2023114670A patent/JP2023139074A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524475A (ja) | 1998-09-11 | 2002-08-06 | サーファシン ディベロップメント カンパニー, エルエルシー | 局所経皮抗菌組成物 |
JP5068408B2 (ja) | 1999-12-13 | 2012-11-07 | エシコン・インコーポレイテッド | 深部浸透性抗菌剤組成物 |
JP2009528360A (ja) | 2006-02-28 | 2009-08-06 | ベクトン・ディキンソン・アンド・カンパニー | 抗菌性組成物及び固定型カテーテルのための方法 |
JP2017515886A (ja) | 2014-03-28 | 2017-06-15 | ガーマ ヘルスケア リミテッドGama Healthcare Ltd | 液体抗菌組成物 |
Non-Patent Citations (2)
Title |
---|
杉中茂之,食品工場での有害微生物対策と洗浄除菌剤,その開発事例,日本醸造協会誌,日本,公益財団法人日本醸造協会,2013年03月15日,vol. 108, No. 3,pp. 141-155 |
第5版 消毒剤マニュアル -消毒剤の特徴・使用法・使用上の留意点-, [online],2012年02月01日,pp. 15-198,[2022.04.28検索], インターネット,<URL: https://www.kenei-pharm.com/cms/wp-content/uploads/2016/11/shoudokukannrenn_03.pdf> |
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AU2018294246A1 (en) | 2020-02-13 |
EP3645017A1 (en) | 2020-05-06 |
MX2019015822A (es) | 2022-09-05 |
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