JP7452918B2 - マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの分化誘導方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ - Google Patents

マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの分化誘導方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ Download PDF

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JP7452918B2
JP7452918B2 JP2023569552A JP2023569552A JP7452918B2 JP 7452918 B2 JP7452918 B2 JP 7452918B2 JP 2023569552 A JP2023569552 A JP 2023569552A JP 2023569552 A JP2023569552 A JP 2023569552A JP 7452918 B2 JP7452918 B2 JP 7452918B2
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macrophage
cells
macrophages
stimulating factor
colony stimulating
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JPWO2023120673A5 (https=
JPWO2023120673A1 (https=
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博満 原
信英 松本
憲司 豊永
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Kagoshima University NUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2023569552A 2021-12-22 2022-12-22 マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの分化誘導方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ Active JP7452918B2 (ja)

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JP2024020753A JP2024040454A (ja) 2021-12-22 2024-02-15 マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの培養方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ

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JP2021208420 2021-12-22
JP2021208420 2021-12-22
PCT/JP2022/047472 WO2023120673A1 (ja) 2021-12-22 2022-12-22 マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの培養方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ

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JPWO2023120673A1 JPWO2023120673A1 (https=) 2023-06-29
JPWO2023120673A5 JPWO2023120673A5 (https=) 2024-01-19
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JP2024020753A Pending JP2024040454A (ja) 2021-12-22 2024-02-15 マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの培養方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017136014A (ja) 2016-02-03 2017-08-10 富士ソフト株式会社 Ｍ２様マクロファージ組成物の製造方法、およびｍ２様マクロファージ組成物原料
JP2017523814A (ja) 2014-08-08 2017-08-24 アレクトル エルエルシー 抗ｔｒｅｍ２抗体及びその使用方法
JP2018522556A (ja) 2015-07-23 2018-08-16 コリア リサーチ インスティチュート オブ ケミカル テクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃｈｅｍｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ 脂肪細胞とマクロファージの三次元共培養方法
JP2021513329A (ja) 2018-01-31 2021-05-27 アレクター リミテッド ライアビリティ カンパニー 抗ｍｓ４ａ４ａ抗体及びその使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015047125A (ja) 2013-09-02 2015-03-16 テルモ株式会社 マクロファージの分化誘導剤およびそれを用いるマクロファージの分化誘導方法
AU2016334051B2 (en) * 2015-10-06 2023-10-26 Alector Llc Anti-TREM2 antibodies and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017523814A (ja) 2014-08-08 2017-08-24 アレクトル エルエルシー 抗ｔｒｅｍ２抗体及びその使用方法
JP2018522556A (ja) 2015-07-23 2018-08-16 コリア リサーチ インスティチュート オブ ケミカル テクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃｈｅｍｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ 脂肪細胞とマクロファージの三次元共培養方法
JP2017136014A (ja) 2016-02-03 2017-08-10 富士ソフト株式会社 Ｍ２様マクロファージ組成物の製造方法、およびｍ２様マクロファージ組成物原料
JP2021513329A (ja) 2018-01-31 2021-05-27 アレクター リミテッド ライアビリティ カンパニー 抗ｍｓ４ａ４ａ抗体及びその使用方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BMC Immunology，2021年05月，22:30
Cell，2017年，Vol.169，pp.1276-1290
Cell，2019年，Vol.178，pp.686-698
Diabetes，2015年，Vol.64，pp.117-127
Nature Communications，2021年04月，Vol.12, No.1，Article No.2299
The Journal of Immunology，2010年，Vol.184， pp.6522-6528

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US20250059509A1 (en) 2025-02-20
EP4455275A4 (en) 2026-03-18
JP2024040454A (ja) 2024-03-25
EP4455275A1 (en) 2024-10-30
WO2023120673A1 (ja) 2023-06-29
JPWO2023120673A1 (https=) 2023-06-29

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