JP7432643B2 - 眼科製品用の液体組成物 - Google Patents
眼科製品用の液体組成物 Download PDFInfo
- Publication number
- JP7432643B2 JP7432643B2 JP2022055450A JP2022055450A JP7432643B2 JP 7432643 B2 JP7432643 B2 JP 7432643B2 JP 2022055450 A JP2022055450 A JP 2022055450A JP 2022055450 A JP2022055450 A JP 2022055450A JP 7432643 B2 JP7432643 B2 JP 7432643B2
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- liquid composition
- derivative
- zinc
- weight percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 118
- 239000007788 liquid Substances 0.000 title claims description 112
- 229940088594 vitamin Drugs 0.000 claims description 56
- 229930003231 vitamin Natural products 0.000 claims description 56
- 235000013343 vitamin Nutrition 0.000 claims description 56
- 239000011782 vitamin Substances 0.000 claims description 56
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 49
- 239000007853 buffer solution Substances 0.000 claims description 35
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 32
- 150000003751 zinc Chemical class 0.000 claims description 27
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 26
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 24
- 239000004094 surface-active agent Substances 0.000 claims description 22
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 20
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 19
- 239000011576 zinc lactate Substances 0.000 claims description 19
- 235000000193 zinc lactate Nutrition 0.000 claims description 19
- 229940050168 zinc lactate Drugs 0.000 claims description 19
- 229960001763 zinc sulfate Drugs 0.000 claims description 19
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 19
- 239000000126 substance Substances 0.000 claims description 18
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 claims description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 16
- 229930003779 Vitamin B12 Natural products 0.000 claims description 16
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 16
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 16
- 235000019163 vitamin B12 Nutrition 0.000 claims description 16
- 239000011715 vitamin B12 Substances 0.000 claims description 16
- 235000019158 vitamin B6 Nutrition 0.000 claims description 16
- 239000011726 vitamin B6 Substances 0.000 claims description 16
- 229940011671 vitamin b6 Drugs 0.000 claims description 16
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 15
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 claims description 15
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 claims description 15
- 229940013640 flavin mononucleotide Drugs 0.000 claims description 15
- 239000011768 flavin mononucleotide Substances 0.000 claims description 15
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 claims description 15
- 229960002477 riboflavin Drugs 0.000 claims description 15
- 235000002639 sodium chloride Nutrition 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 13
- 229930003427 Vitamin E Natural products 0.000 claims description 13
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims description 13
- 239000011714 flavin adenine dinucleotide Substances 0.000 claims description 13
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 claims description 13
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 13
- 229920002674 hyaluronan Polymers 0.000 claims description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims description 13
- 150000003287 riboflavins Chemical class 0.000 claims description 13
- 235000019165 vitamin E Nutrition 0.000 claims description 13
- 239000011709 vitamin E Substances 0.000 claims description 13
- 229940046009 vitamin E Drugs 0.000 claims description 13
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 11
- 239000010452 phosphate Substances 0.000 claims description 11
- 229930003471 Vitamin B2 Natural products 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 235000019164 vitamin B2 Nutrition 0.000 claims description 10
- 239000011716 vitamin B2 Substances 0.000 claims description 10
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 8
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 8
- 229930003537 Vitamin B3 Natural products 0.000 claims description 8
- 229930003268 Vitamin C Natural products 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 8
- 150000001867 cobalamins Chemical class 0.000 claims description 8
- 150000002814 niacins Chemical class 0.000 claims description 8
- 229960003512 nicotinic acid Drugs 0.000 claims description 8
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 8
- 235000019155 vitamin A Nutrition 0.000 claims description 8
- 239000011719 vitamin A Substances 0.000 claims description 8
- 235000019160 vitamin B3 Nutrition 0.000 claims description 8
- 239000011708 vitamin B3 Substances 0.000 claims description 8
- 150000003697 vitamin B6 derivatives Chemical class 0.000 claims description 8
- 235000019154 vitamin C Nutrition 0.000 claims description 8
- 239000011718 vitamin C Substances 0.000 claims description 8
- 150000003700 vitamin C derivatives Chemical class 0.000 claims description 8
- 150000003712 vitamin E derivatives Chemical class 0.000 claims description 8
- 229940045997 vitamin a Drugs 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 5
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 5
- -1 chelated zinc Chemical compound 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 235000019192 riboflavin Nutrition 0.000 claims description 5
- 239000002151 riboflavin Substances 0.000 claims description 5
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 5
- 239000004246 zinc acetate Substances 0.000 claims description 5
- 239000011592 zinc chloride Substances 0.000 claims description 5
- 235000005074 zinc chloride Nutrition 0.000 claims description 5
- 229960001939 zinc chloride Drugs 0.000 claims description 5
- 239000011746 zinc citrate Substances 0.000 claims description 5
- 235000006076 zinc citrate Nutrition 0.000 claims description 5
- 229940068475 zinc citrate Drugs 0.000 claims description 5
- 239000011670 zinc gluconate Substances 0.000 claims description 5
- 235000011478 zinc gluconate Nutrition 0.000 claims description 5
- 229960000306 zinc gluconate Drugs 0.000 claims description 5
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 229940038879 chelated zinc Drugs 0.000 claims 2
- 229960000314 zinc acetate Drugs 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 description 29
- 238000011156 evaluation Methods 0.000 description 23
- 208000024891 symptom Diseases 0.000 description 23
- 230000035807 sensation Effects 0.000 description 13
- 239000000463 material Substances 0.000 description 9
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 229920000136 polysorbate Polymers 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000002349 favourable effect Effects 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 229940023490 ophthalmic product Drugs 0.000 description 5
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 4
- 239000004327 boric acid Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000004304 visual acuity Effects 0.000 description 4
- IUVCFHHAEHNCFT-INIZCTEOSA-N 2-[(1s)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one Chemical compound C1=C(F)C(OC(C)C)=CC=C1C(C1=C(N)N=CN=C11)=NN1[C@@H](C)C1=C(C=2C=C(F)C=CC=2)C(=O)C2=CC(F)=CC=C2O1 IUVCFHHAEHNCFT-INIZCTEOSA-N 0.000 description 3
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 235000016804 zinc Nutrition 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 description 1
- HMFKFHLTUCJZJO-UHFFFAOYSA-N 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO HMFKFHLTUCJZJO-UHFFFAOYSA-N 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- NTYZDAJPNNBYED-UHFFFAOYSA-M sodium;2-(2-dodecanoyloxypropanoyloxy)propanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O NTYZDAJPNNBYED-UHFFFAOYSA-M 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/74—Carboxylates or sulfonates esters of polyoxyalkylene glycols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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Description
ここで、Rは、ヒドロキシ基、リン酸基及びリン酸基含有関連誘導体である。ビタミンB2誘導体は、例えばフラビンモノヌクレオチド、フラビンアデニンジヌクレオチドであってよいが、これらに限定されない。本開示の1つ又は複数の実施形態において、第1のビタミンは、リボフラビン、フラビンモノヌクレオチド及びその塩、フラビンアデニンジヌクレオチド及びその塩、又はそれらの組み合わせを含む。液体組成物における第1のビタミンの重量パーセント濃度は、1×10-5%~1%であり、好ましくは5×10-5%~0.5%であり、例えば1×10-4%、5×10-4%、1×10-3%、5×10-3%、0.01%、0.05%又は0.1%である。注意すべきこととして、液体組成物における第1のビタミンの重量パーセント濃度が上記範囲又は数値である場合、予期できない技術的効果がもたらされ、後で詳細に説明する。
1.緩衝溶液:緩衝溶液に四ホウ酸ナトリウム、ホウ酸及び塩化ナトリウムが同時に含有される。
2.親水性物質:ヒアルロン酸(Hyaluronic acid)及び平均分子量が400のポリビニルアルコール(PEG 400)。
3.界面活性剤:液体組成物における重量パーセント濃度が0.08%のポリオキシエチレンソルビタンモノオレエート(TWEEN(R) 80)。
4.亜鉛塩:硫酸亜鉛、乳酸亜鉛。
5.ビタミン:ビタミンB6、ビタミンB12、ビタミンE。
Claims (19)
- コンタクトレンズの保存用の液体組成物であって、
緩衝溶液;
前記緩衝溶液に溶解した亜鉛塩、ここで、前記液体組成物における前記亜鉛塩の重量パーセント濃度は、1×10-5%~3%である;
親水性物質、ここで、親水性物質は、平均分子量が400のポリエチレングリコール、または平均分子量が400のポリエチレングリコールとヒアルロン酸との組み合わせを含み、ここで、前記液体組成物における前記親水性物質の重量パーセント濃度は1×10 -3 %~3%である;および
界面活性剤、ここで、界面活性剤はポリオキシエチレンソルビタンモノラウレートを含み、前記液体組成物における前記親水性物質の重量パーセント濃度は1×10 -3 %~2%である、
を含む、前記液体組成物。 - 前記亜鉛塩が、硫酸亜鉛、硫酸亜鉛水和物、グルコン酸亜鉛、乳酸亜鉛、塩化亜鉛、クエン酸亜鉛、キレート化亜鉛、酢酸亜鉛、又はそれらの組み合わせを含む、請求項1に記載の液体組成物。
- 前記緩衝溶液が、ホウ酸塩、リン酸塩、又はそれらの組み合わせを含む、請求項1~2の何れか一項に記載の液体組成物。
- ビタミンを更に含む、請求項1~3の何れか一項に記載の液体組成物。
- 前記ビタミンが、ビタミンA、ビタミンA誘導体、ビタミンB3、ビタミンB3誘導体、ビタミンB6、ビタミンB6誘導体、ビタミンB12、ビタミンB12誘導体、ビタミンC、ビタミンC誘導体、ビタミンE、ビタミンE誘導体、又はそれらの組み合わせを含む、請求項4に記載の液体組成物。
- 前記液体組成物における前記ビタミンの重量パーセント濃度が、1×10-5%~5%である、請求項4~5の何れか一項に記載の液体組成物。
- コンタクトレンズの保存用の液体組成物であって、
緩衝溶液;
前記緩衝溶液に溶解した第1のビタミン、ここで、前記液体組成物における前記第1のビタミンの重量パーセント濃度が、1×10-5%~1%であり、第1のビタミンは、ビタミンB2、ビタミンB2誘導体、又はそれらの組み合わせを含む;
親水性物質、ここで親水性物質は、平均分子量が400のポリエチレングリコール、または平均分子量が400のポリエチレングリコールとヒアルロン酸との組み合わせを含み、ここで、前記液体組成物における前記親水性物質の重量パーセント濃度が、1×10 -3 %~3%である;および
界面活性剤、ここで、界面活性剤はポリオキシエチレンソルビタンモノラウレートを含み、前記液体組成物における前記親水性物質の重量パーセント濃度は1×10 -3 %~2%である、
を含む、前記液体組成物。 - 前記第1のビタミンが、リボフラビン、フラビンモノヌクレオチド及びその塩、フラビンアデニンジヌクレオチド及びその塩、又はそれらの組み合わせを含む、請求項7に記載の液体組成物。
- 前記緩衝溶液が、ホウ酸塩及びリン酸塩を含む、請求項7~8の何れか一項に記載の液体組成物。
- 第2のビタミンを更に含む、請求項7~9の何れか一項に記載の液体組成物。
- 前記第2のビタミンが、ビタミンA、ビタミンA誘導体、ビタミンB3、ビタミンB3誘導体、ビタミンB6、ビタミンB6誘導体、ビタミンB12、ビタミンB12誘導体、ビタミンC、ビタミンC誘導体、ビタミンE、ビタミンE誘導体、又はそれらの組み合わせを含む、請求項10に記載の液体組成物。
- 前記液体組成物における前記第2のビタミンの重量パーセント濃度が、1×10-5%~5%である、請求項10~11の何れか一項に記載の液体組成物。
- コンタクトレンズの保存用の液体組成物であって、
緩衝溶液;
前記緩衝溶液に溶解した亜鉛塩、ここで、前記液体組成物における前記亜鉛塩の重量パーセント濃度は、1×10-5%~3%である;
前記緩衝溶液に溶解した第1のビタミン、ここで、前記液体組成物における前記第1のビタミンの重量パーセント濃度は、1×10-5%~1%であり、第1のビタミンは、ビタミンB2、ビタミンB2誘導体、又はそれらの組み合わせを含む;
親水性物質、ここで、親水性物質は、平均分子量が400のポリビニルアルコール、または平均分子量が400のポリビニルアルコールとヒアルロン酸との組み合わせを含み、ここで、前記液体組成物における前記親水性物質の重量パーセント濃度が、1×10 -3 %~3%である;および
界面活性剤、ここで、界面活性剤はポリオキシエチレンソルビタンモノラウレートを含み、前記液体組成物における前記親水性物質の重量パーセント濃度は1×10 -3 %~2%である、
を含む、前記液体組成物。 - 前記亜鉛塩が、硫酸亜鉛、硫酸亜鉛水和物、グルコン酸亜鉛、乳酸亜鉛、塩化亜鉛、クエン酸亜鉛、キレート化亜鉛、酢酸亜鉛、又はそれらの組み合わせを含む、請求項13に記載の液体組成物。
- 前記第1のビタミンが、リボフラビン、フラビンモノヌクレオチド及びその塩、フラビンアデニンジヌクレオチド及びその塩、又はそれらの組み合わせを含む、請求項13~14の何れか一項に記載の液体組成物。
- 前記緩衝溶液が、ホウ酸塩、リン酸塩、又はそれらの組み合わせを含む、請求項13~15の何れか一項に記載の液体組成物。
- 第2のビタミンを更に含む、請求項13~16の何れか一項に記載の液体組成物。
- 前記第2のビタミンが、ビタミンA、ビタミンA誘導体、ビタミンB3、ビタミンB3誘導体、ビタミンB6、ビタミンB6誘導体、ビタミンB12、ビタミンB12誘導体、ビタミンC、ビタミンC誘導体、ビタミンE、ビタミンE誘導体、又はそれらの組み合わせを含む、請求項17に記載の液体組成物。
- 前記液体組成物における前記第2のビタミンの重量パーセント濃度が、1×10-5%~5%である、請求項17~18の何れか一項に記載の液体組成物。
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JP4987170B1 (ja) | 2011-09-02 | 2012-07-25 | 株式会社メニコン | コンタクトレンズの親水性向上システム及びそれのコンタクトレンズ・パッケージングへの適用 |
US20170151734A1 (en) | 2014-04-01 | 2017-06-01 | Safilens S.R.L. | Method for introducing an active compound into a soft hydrated contact lens |
JP2016133594A (ja) | 2015-01-19 | 2016-07-25 | 株式会社メニコン | コンタクトレンズ用保存液、コンタクトレンズの保存方法及びコンタクトレンズの製造方法 |
JP2017075145A (ja) | 2015-10-15 | 2017-04-20 | ロート製薬株式会社 | 眼科組成物 |
WO2017203550A1 (ja) | 2016-05-26 | 2017-11-30 | 株式会社オフテクス | 加水分解ヒアルロン酸誘導体及びカチオン系殺菌剤を含有するコンタクトレンズ用液剤 |
JP2018005209A (ja) | 2016-06-27 | 2018-01-11 | ペガヴィジョン コーポレーションPegavision Corporation | コンタクトレンズ処理用の溶液及びコンタクトレンズの包装システム |
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US20230037121A1 (en) | 2023-02-02 |
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