JP7432361B2 - ヒトインスリンまたはそのアナログのアシル化誘導体 - Google Patents

ヒトインスリンまたはそのアナログのアシル化誘導体 Download PDF

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Publication number
JP7432361B2
JP7432361B2 JP2019503703A JP2019503703A JP7432361B2 JP 7432361 B2 JP7432361 B2 JP 7432361B2 JP 2019503703 A JP2019503703 A JP 2019503703A JP 2019503703 A JP2019503703 A JP 2019503703A JP 7432361 B2 JP7432361 B2 JP 7432361B2
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human insulin
zinc complex
acylated derivative
insulin analog
group
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JP2019526537A (ja
JP2019526537A5 (https=
Inventor
徳玉 劉
宏偉 王
亮 趙
菲菲 王
翔 曾
涛 王
亜里 王
雨▲ルゥ▼ 戴
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Jiangsu Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Pharmaceutical Co Ltd
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Priority to JP2022066071A priority Critical patent/JP2022095872A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2019503703A 2016-08-02 2017-08-01 ヒトインスリンまたはそのアナログのアシル化誘導体 Active JP7432361B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022066071A JP2022095872A (ja) 2016-08-02 2022-04-13 ヒトインスリンまたはそのアナログのアシル化誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201610625257 2016-08-02
CN201610625257.5 2016-08-02
CN201610779132 2016-08-31
CN201610779132.8 2016-08-31
PCT/CN2017/095377 WO2018024186A1 (zh) 2016-08-02 2017-08-01 一种人胰岛素或其类似物的酰化衍生物

Related Child Applications (1)

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JP2022066071A Division JP2022095872A (ja) 2016-08-02 2022-04-13 ヒトインスリンまたはそのアナログのアシル化誘導体

Publications (3)

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JP2019526537A JP2019526537A (ja) 2019-09-19
JP2019526537A5 JP2019526537A5 (https=) 2020-07-02
JP7432361B2 true JP7432361B2 (ja) 2024-02-16

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JP2019503703A Active JP7432361B2 (ja) 2016-08-02 2017-08-01 ヒトインスリンまたはそのアナログのアシル化誘導体
JP2022066071A Pending JP2022095872A (ja) 2016-08-02 2022-04-13 ヒトインスリンまたはそのアナログのアシル化誘導体

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JP2022066071A Pending JP2022095872A (ja) 2016-08-02 2022-04-13 ヒトインスリンまたはそのアナログのアシル化誘導体

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Country Link
US (1) US10815287B2 (https=)
EP (1) EP3495384A4 (https=)
JP (2) JP7432361B2 (https=)
CN (2) CN108463468B (https=)
TW (1) TWI747929B (https=)
WO (1) WO2018024186A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021512124A (ja) * 2018-02-01 2021-05-13 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Ｊｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． ヒトインスリンアナログのアシル化誘導体を含有する医薬組成物及びその調製方法
CN111094572B (zh) 2018-02-09 2023-04-04 江苏恒瑞医药股份有限公司 一种密码子优化的人胰岛素类似物前体基因和信号肽基因
EP3805257A4 (en) 2018-05-24 2022-03-16 Jiangsu Hengrui Medicine Co., Ltd. METHOD OF PRODUCTION OF A PRECURSOR OF RECOMBINANT HUMAN INSULIN OR ANALOGUE THEREOF
KR20210102347A (ko) 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
CN118754967A (zh) 2019-12-30 2024-10-11 甘李药业股份有限公司 胰岛素衍生物
TW202229324A (zh) * 2020-11-27 2022-08-01 大陸商江蘇恒瑞醫藥股份有限公司 製備胰島素或其類似物的醯化衍生物的方法
CN112939771A (zh) * 2021-01-28 2021-06-11 宁夏蓝博思化学技术有限公司 长链烷基二酸单叔丁酯的制备方法
CN115385843A (zh) * 2021-05-24 2022-11-25 广东东阳光药业有限公司 一种新型的酰化胰岛素类似物
AU2022300061A1 (en) 2021-06-25 2024-02-01 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin-containing pharmaceutical composition
US20250340610A1 (en) 2022-01-28 2025-11-06 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin
CN117756914B (zh) * 2023-12-15 2024-09-03 瀚晖制药有限公司 依柯胰岛素的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009522231A (ja) 2005-12-28 2009-06-11 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
JP2015501819A (ja) 2011-12-15 2015-01-19 シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドＳｈａｎｇｈａｉ Ｈｅｎｇｒｕｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ヒト・インスリン類似体及びそのアシル化誘導体

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PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
EP1132404A3 (en) 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
CN1163574A (zh) * 1994-11-17 1997-10-29 伊莱利利公司 酰化的胰岛素类似物
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
AU2003208316A1 (en) * 2002-03-13 2003-09-22 Novo Nordisk A/S Minimising body weight gain in insulin treatment
DK2275439T3 (da) 2003-08-05 2014-05-12 Novo Nordisk As Hidtil ukendte insulinderivater
CA2531988C (en) 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
JP5721432B2 (ja) 2007-08-15 2015-05-20 ノボ・ノルデイスク・エー／エス アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン
HUE032284T2 (en) * 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
US8935928B2 (en) * 2011-10-10 2015-01-20 Lockheed Martin Corporation Integrated air-cycle refrigeration and power generation system
CN106496322A (zh) 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 人胰岛素或其类似物的酰化衍生物的制备方法
KR20180105236A (ko) * 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법

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JP2009522231A (ja) 2005-12-28 2009-06-11 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
JP2015501819A (ja) 2011-12-15 2015-01-19 シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドＳｈａｎｇｈａｉ Ｈｅｎｇｒｕｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ヒト・インスリン類似体及びそのアシル化誘導体

Also Published As

Publication number Publication date
CN108463468A (zh) 2018-08-28
US10815287B2 (en) 2020-10-27
EP3495384A4 (en) 2020-02-26
EP3495384A1 (en) 2019-06-12
JP2019526537A (ja) 2019-09-19
CN114478747A (zh) 2022-05-13
CN108463468B (zh) 2022-03-04
TWI747929B (zh) 2021-12-01
JP2022095872A (ja) 2022-06-28
WO2018024186A1 (zh) 2018-02-08
US20190169257A1 (en) 2019-06-06
TW201805300A (zh) 2018-02-16
CN114478747B (zh) 2024-06-14

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