JP7427212B2 - 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 - Google Patents
非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 Download PDFInfo
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- JP7427212B2 JP7427212B2 JP2018560887A JP2018560887A JP7427212B2 JP 7427212 B2 JP7427212 B2 JP 7427212B2 JP 2018560887 A JP2018560887 A JP 2018560887A JP 2018560887 A JP2018560887 A JP 2018560887A JP 7427212 B2 JP7427212 B2 JP 7427212B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021214205A JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919551P | 2013-12-20 | 2013-12-20 | |
| US15/161,137 US20160317519A1 (en) | 2013-12-20 | 2016-05-20 | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| US15/161,137 | 2016-05-20 | ||
| PCT/US2017/033843 WO2017201532A1 (en) | 2013-12-20 | 2017-05-22 | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021214205A Division JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519519A JP2019519519A (ja) | 2019-07-11 |
| JP2019519519A5 JP2019519519A5 (https=) | 2020-06-25 |
| JP7427212B2 true JP7427212B2 (ja) | 2024-02-05 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560887A Active JP7427212B2 (ja) | 2013-12-20 | 2017-05-22 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2021214205A Withdrawn JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A Pending JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A Pending JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021214205A Withdrawn JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A Pending JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A Pending JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非erk mapk経路阻害剤耐性のがんを処置するための方法および組成物 |
Country Status (16)
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|---|---|
| US (5) | US20160317519A1 (https=) |
| EP (2) | EP3458056B1 (https=) |
| JP (4) | JP7427212B2 (https=) |
| KR (2) | KR20190009804A (https=) |
| CN (2) | CN109475541A (https=) |
| AU (3) | AU2017267804B2 (https=) |
| BR (1) | BR112018073786A2 (https=) |
| CA (1) | CA3024703A1 (https=) |
| CL (1) | CL2018003282A1 (https=) |
| ES (1) | ES3056393T3 (https=) |
| IL (2) | IL294056A (https=) |
| MX (2) | MX392121B (https=) |
| RU (1) | RU2018145048A (https=) |
| SG (1) | SG11201810287RA (https=) |
| WO (2) | WO2015095842A2 (https=) |
| ZA (2) | ZA201808480B (https=) |
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| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| WO2015095842A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| BR112018012255A2 (pt) * | 2015-12-18 | 2018-12-04 | Ignyta Inc | método para tratar câncer |
| WO2017180581A1 (en) * | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| WO2017180817A1 (en) * | 2016-04-15 | 2017-10-19 | Musc Foundation For Research Development | Treatment of septicemia and ards with erk inhibitors |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| AU2018269982B2 (en) * | 2017-05-16 | 2024-06-13 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical BRAF mutations |
| WO2019084459A1 (en) * | 2017-10-26 | 2019-05-02 | Xynomic Pharmaceuticals, Inc. | CRYSTALLINE SALTS AND FORMS OF B-RAF KINASE INHIBITOR |
| CN112218634A (zh) * | 2018-04-09 | 2021-01-12 | G1治疗公司 | 具有驱动致癌突变的癌症的治疗 |
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| CN114981298B (zh) * | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| KR102697384B1 (ko) * | 2022-01-13 | 2024-08-22 | 팔라디바이오텍 주식회사 | 리셉터 티로신 키나제 저해제를 탐색하는 방법 |
| CN115177622B (zh) * | 2022-07-19 | 2024-09-17 | 中南大学湘雅二医院 | 多个化合物在制备治疗骨髓增殖性肿瘤的药物中的应用 |
| WO2026020045A1 (en) * | 2024-07-17 | 2026-01-22 | 4M Therapeutics Inc. | N-desmethyl ruboxistaurin as a rsk inhibitor for therapeutic use |
| WO2026030476A1 (en) * | 2024-07-30 | 2026-02-05 | Genentech, Inc. | Precision medicine for optimal dosage of combined therapies systems and methods of use thereof |
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| WO2015095833A1 (en) | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Treatment of hematologic cancers |
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