JP2019519519A5 - - Google Patents
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- Publication number
- JP2019519519A5 JP2019519519A5 JP2018560887A JP2018560887A JP2019519519A5 JP 2019519519 A5 JP2019519519 A5 JP 2019519519A5 JP 2018560887 A JP2018560887 A JP 2018560887A JP 2018560887 A JP2018560887 A JP 2018560887A JP 2019519519 A5 JP2019519519 A5 JP 2019519519A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mutation
- mammal
- subject
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000035772 mutation Effects 0.000 claims description 13
- 241000124008 Mammalia Species 0.000 claims description 10
- 201000001441 melanoma Diseases 0.000 claims description 9
- 244000144972 livestock Species 0.000 claims description 7
- KSERXGMCDHOLSS-LJQANCHMSA-N n-[(1s)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1h-pyrrole-2-carboxamide Chemical compound C1=NC(NC(C)C)=CC(C=2C=C(NC=2)C(=O)N[C@H](CO)C=2C=C(Cl)C=CC=2)=C1Cl KSERXGMCDHOLSS-LJQANCHMSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 230000001394 metastastic effect Effects 0.000 claims description 5
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 5
- 241000282412 Homo Species 0.000 claims description 4
- 102000043136 MAP kinase family Human genes 0.000 claims description 4
- 108091054455 MAP kinase family Proteins 0.000 claims description 4
- 241000288906 Primates Species 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000003981 vehicle Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021214205A JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919551P | 2013-12-20 | 2013-12-20 | |
| US15/161,137 US20160317519A1 (en) | 2013-12-20 | 2016-05-20 | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| US15/161,137 | 2016-05-20 | ||
| PCT/US2017/033843 WO2017201532A1 (en) | 2013-12-20 | 2017-05-22 | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021214205A Division JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519519A JP2019519519A (ja) | 2019-07-11 |
| JP2019519519A5 true JP2019519519A5 (https=) | 2020-06-25 |
| JP7427212B2 JP7427212B2 (ja) | 2024-02-05 |
Family
ID=53403903
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560887A Active JP7427212B2 (ja) | 2013-12-20 | 2017-05-22 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2021214205A Withdrawn JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A Pending JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A Pending JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021214205A Withdrawn JP2022034068A (ja) | 2013-12-20 | 2021-12-28 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2024108968A Pending JP2024133638A (ja) | 2013-12-20 | 2024-07-05 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
| JP2026001737A Pending JP2026053745A (ja) | 2013-12-20 | 2026-01-07 | 非ｅｒｋ ｍａｐｋ経路阻害剤耐性のがんを処置するための方法および組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20160317519A1 (https=) |
| EP (2) | EP3458056B1 (https=) |
| JP (4) | JP7427212B2 (https=) |
| KR (2) | KR20190009804A (https=) |
| CN (2) | CN109475541A (https=) |
| AU (3) | AU2017267804B2 (https=) |
| BR (1) | BR112018073786A2 (https=) |
| CA (1) | CA3024703A1 (https=) |
| CL (1) | CL2018003282A1 (https=) |
| ES (1) | ES3056393T3 (https=) |
| IL (2) | IL294056A (https=) |
| MX (2) | MX392121B (https=) |
| RU (1) | RU2018145048A (https=) |
| SG (1) | SG11201810287RA (https=) |
| WO (2) | WO2015095842A2 (https=) |
| ZA (2) | ZA201808480B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613743B1 (en) | 2008-01-04 | 2022-03-16 | Intellikine, LLC | Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| WO2015095842A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| BR112018012255A2 (pt) * | 2015-12-18 | 2018-12-04 | Ignyta Inc | método para tratar câncer |
| WO2017180581A1 (en) * | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| WO2017180817A1 (en) * | 2016-04-15 | 2017-10-19 | Musc Foundation For Research Development | Treatment of septicemia and ards with erk inhibitors |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| AU2018269982B2 (en) * | 2017-05-16 | 2024-06-13 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical BRAF mutations |
| WO2019084459A1 (en) * | 2017-10-26 | 2019-05-02 | Xynomic Pharmaceuticals, Inc. | CRYSTALLINE SALTS AND FORMS OF B-RAF KINASE INHIBITOR |
| CN112218634A (zh) * | 2018-04-09 | 2021-01-12 | G1治疗公司 | 具有驱动致癌突变的癌症的治疗 |
| CN110656172A (zh) * | 2019-01-14 | 2020-01-07 | 南方医科大学珠江医院 | 一种预测小细胞肺癌对ep化疗方案敏感性的分子标志物及试剂盒 |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| CN114981298B (zh) * | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| KR102697384B1 (ko) * | 2022-01-13 | 2024-08-22 | 팔라디바이오텍 주식회사 | 리셉터 티로신 키나제 저해제를 탐색하는 방법 |
| CN115177622B (zh) * | 2022-07-19 | 2024-09-17 | 中南大学湘雅二医院 | 多个化合物在制备治疗骨髓增殖性肿瘤的药物中的应用 |
| WO2026020045A1 (en) * | 2024-07-17 | 2026-01-22 | 4M Therapeutics Inc. | N-desmethyl ruboxistaurin as a rsk inhibitor for therapeutic use |
| WO2026030476A1 (en) * | 2024-07-30 | 2026-02-05 | Genentech, Inc. | Precision medicine for optimal dosage of combined therapies systems and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE220114T1 (de) | 1993-03-19 | 2002-07-15 | Sequenom Inc | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
| US6140053A (en) | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US7439016B1 (en) | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| US7601497B2 (en) | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| GB0320059D0 (en) | 2003-08-27 | 2003-10-01 | Solexa Ltd | A method of sequencing |
| LT3305776T (lt) * | 2004-05-14 | 2020-01-10 | Vertex Pharmaceuticals Incorporated | Pirolo junginiai kaip erk baltymo kinazės inhibitoriai, ir farmacinės kompozicijos su šiais junginiais |
| US7582623B2 (en) | 2004-05-20 | 2009-09-01 | The Regents Of The University Of California | Photoactive metal nitrosyls for blood pressure regulation and cancer therapy |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| CA2609387A1 (en) * | 2005-05-27 | 2006-11-30 | Bayer Healthcare Ag | Combination therapy comprising diaryl ureas for treating diseases |
| WO2010062546A1 (en) | 2008-10-27 | 2010-06-03 | Qiagen Gaithersburg Inc. | Fast results hybrid capture assay on an automated platform |
| KR20120046018A (ko) | 2010-10-04 | 2012-05-09 | 삼성테크윈 주식회사 | 단일 뉴클레오티드 다형성의 실시간 ｐｃｒ 검출 |
| WO2012125848A2 (en) | 2011-03-16 | 2012-09-20 | Baylor College Of Medicine | A method for comprehensive sequence analysis using deep sequencing technology |
| DK2884979T3 (da) | 2012-08-17 | 2019-09-02 | Hoffmann La Roche | Kombinationsbehandlinger mod melanom omfattende indgivelse af cobimetinib og vemurafenib |
| EP2953622B1 (en) | 2013-02-11 | 2021-03-24 | Abraxis BioScience, LLC | Methods of treating melanoma |
| EP2958592A1 (en) | 2013-02-22 | 2015-12-30 | F. Hoffmann-La Roche AG | Methods of treating cancer and preventing drug resistance |
| WO2015095833A1 (en) | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Treatment of hematologic cancers |
| WO2015095842A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| CA3240745A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatment using combinations of erk and raf inhibitors |
| WO2015095834A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using erk1/2 and bcl-2 family inhibitors |
| JP6543612B2 (ja) * | 2014-03-04 | 2019-07-10 | 浩文 山本 | 大腸癌の治療剤、及び大腸癌患者の予後の予測方法 |
| WO2016025649A1 (en) * | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a dot1l inhibitor and related methods |
| AU2016211246B2 (en) * | 2015-01-30 | 2020-08-27 | Biomed Valley Discoveries, Inc. | Crystalline forms of C21H22CI2N4O2 |
| JP7180977B2 (ja) * | 2015-01-30 | 2022-11-30 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | 結晶性Ｃ２１Ｈ２２Ｃｌ２Ｎ４Ｏ２マロン酸塩 |
-
2014
- 2014-12-19 WO PCT/US2014/071749 patent/WO2015095842A2/en not_active Ceased
-
2016
- 2016-05-20 US US15/161,137 patent/US20160317519A1/en not_active Abandoned
-
2017
- 2017-05-22 EP EP17800334.9A patent/EP3458056B1/en active Active
- 2017-05-22 CN CN201780044255.XA patent/CN109475541A/zh active Pending
- 2017-05-22 BR BR112018073786-0A patent/BR112018073786A2/pt not_active Application Discontinuation
- 2017-05-22 ES ES17800334T patent/ES3056393T3/es active Active
- 2017-05-22 MX MX2018014231A patent/MX392121B/es unknown
- 2017-05-22 KR KR1020187037187A patent/KR20190009804A/ko not_active Ceased
- 2017-05-22 JP JP2018560887A patent/JP7427212B2/ja active Active
- 2017-05-22 RU RU2018145048A patent/RU2018145048A/ru not_active Application Discontinuation
- 2017-05-22 CA CA3024703A patent/CA3024703A1/en active Pending
- 2017-05-22 IL IL294056A patent/IL294056A/en unknown
- 2017-05-22 US US16/302,955 patent/US11246859B2/en active Active
- 2017-05-22 SG SG11201810287RA patent/SG11201810287RA/en unknown
- 2017-05-22 AU AU2017267804A patent/AU2017267804B2/en active Active
- 2017-05-22 IL IL263108A patent/IL263108B/en unknown
- 2017-05-22 KR KR1020237004648A patent/KR20230025941A/ko not_active Ceased
- 2017-05-22 WO PCT/US2017/033843 patent/WO2017201532A1/en not_active Ceased
- 2017-05-22 CN CN202510671199.9A patent/CN120501744A/zh active Pending
- 2017-05-22 EP EP25207698.9A patent/EP4653055A3/en active Pending
- 2017-10-30 US US15/797,593 patent/US10881646B2/en active Active
-
2018
- 2018-11-19 CL CL2018003282A patent/CL2018003282A1/es unknown
- 2018-11-20 MX MX2022005473A patent/MX2022005473A/es unknown
- 2018-12-14 ZA ZA2018/08480A patent/ZA201808480B/en unknown
-
2020
- 2020-10-23 US US17/078,255 patent/US20210038587A1/en active Pending
- 2020-12-11 ZA ZA2020/07734A patent/ZA202007734B/en unknown
-
2021
- 2021-12-23 US US17/561,076 patent/US12599593B2/en active Active
- 2021-12-28 JP JP2021214205A patent/JP2022034068A/ja not_active Withdrawn
-
2023
- 2023-07-11 AU AU2023204587A patent/AU2023204587B2/en active Active
-
2024
- 2024-07-05 JP JP2024108968A patent/JP2024133638A/ja active Pending
-
2025
- 2025-06-19 AU AU2025204585A patent/AU2025204585A1/en active Pending
-
2026
- 2026-01-07 JP JP2026001737A patent/JP2026053745A/ja active Pending
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