JP7423539B2 - Ｓｇｃ刺激因子の結晶形態 - Google Patents

Ｓｇｃ刺激因子の結晶形態 Download PDF

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JP7423539B2
JP7423539B2 JP2020546378A JP2020546378A JP7423539B2 JP 7423539 B2 JP7423539 B2 JP 7423539B2 JP 2020546378 A JP2020546378 A JP 2020546378A JP 2020546378 A JP2020546378 A JP 2020546378A JP 7423539 B2 JP7423539 B2 JP 7423539B2
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fluorobenzyl
imidazo
trifluoromethyl
pyrazine
triazol
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JP2021515015A5 (enExample
JP2021515015A (ja
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ンティ－アデー，クワメ・ダブリュー
プラサード，リーナ・クマリ
ストルツ，トーマス
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ティセント セラピューティクス インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020546378A 2018-03-07 2019-03-07 Ｓｇｃ刺激因子の結晶形態 Active JP7423539B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862639846P 2018-03-07 2018-03-07
US62/639,846 2018-03-07
PCT/US2019/021080 WO2019173551A1 (en) 2018-03-07 2019-03-07 Crystalline forms of an sgc stimulator

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JP2021515015A JP2021515015A (ja) 2021-06-17
JP2021515015A5 JP2021515015A5 (enExample) 2022-03-14
JP7423539B2 true JP7423539B2 (ja) 2024-01-29

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US (3) US11466015B2 (enExample)
EP (1) EP3762389B1 (enExample)
JP (1) JP7423539B2 (enExample)
KR (1) KR102782810B1 (enExample)
CN (1) CN111836812A (enExample)
AU (1) AU2019231724B2 (enExample)
BR (1) BR112020018212A2 (enExample)
CA (1) CA3092683A1 (enExample)
CL (5) CL2020002284A1 (enExample)
CO (1) CO2020012493A2 (enExample)
CR (1) CR20200458A (enExample)
EA (1) EA202092109A1 (enExample)
ES (1) ES2980256T3 (enExample)
IL (1) IL276853B2 (enExample)
MA (1) MA54638A (enExample)
MX (5) MX2020009183A (enExample)
PE (1) PE20210124A1 (enExample)
PH (1) PH12020551394A1 (enExample)
SG (1) SG11202008641WA (enExample)
TW (1) TWI823903B (enExample)
WO (1) WO2019173551A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111836812A (zh) 2018-03-07 2020-10-27 塞科里昂医疗股份有限公司 sGC刺激剂的晶型
US12220414B2 (en) * 2018-07-11 2025-02-11 Tisento Therapeutics Inc. Use of sGC stimulators for the treatment of mitochondrial disorders
US20230130739A1 (en) * 2020-03-26 2023-04-27 Cyclerion Therapeutics, Inc. DEUTERATED sGC STIMULATORS
CN118221651A (zh) * 2022-12-21 2024-06-21 广东东阳光药业股份有限公司 氟取代的吲唑化合物的晶型及其用途
AU2023412228A1 (en) * 2022-12-21 2025-07-03 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof

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WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
JP7050759B2 (ja) 2016-09-02 2022-04-08 サイクレリオン・セラピューティクス，インコーポレーテッド 縮合二環式ｓｇｃ刺激剤

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JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CZ302691B6 (cs) 1998-07-08 2011-09-07 Sanofi - Aventis Deutschland GmbH N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
CN101939053A (zh) 2007-09-06 2011-01-05 默沙东公司 可溶性的鸟苷酸环化酶活化剂
CA2711134A1 (en) 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin ii receptor antagonists
CA2743864A1 (en) 2008-11-25 2010-06-10 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CA2753434C (en) 2009-02-26 2014-07-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US9284301B2 (en) 2010-03-25 2016-03-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
UA107112C2 (uk) 2010-05-27 2014-11-25 Мерк Шарп Енд Доме Корп. Активатори розчинної гуанілатциклази
TWI532737B (zh) 2010-06-30 2016-05-11 艾諾屋製藥公司 可溶性鳥苷酸環化酶（ｓＧＣ）刺激物
WO2012058132A1 (en) 2010-10-28 2012-05-03 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
JP5878546B2 (ja) 2010-11-09 2016-03-08 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激剤
EP2927231B1 (en) 2012-11-30 2017-09-20 Astellas Pharma Inc. Imidazopyridine compounds
US9776997B2 (en) 2013-06-04 2017-10-03 Bayer Pharma Aktiengesellschaft 3-aryl-substituted imidazo[1,2-A]pyridines and their use
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
EP3227286B1 (de) * 2014-12-02 2018-12-26 Bayer Pharma Aktiengesellschaft Substituierte pyrazolo[1,5-a]pyridine und imidazo[1,2-a]pyrazine und ihre verwendung
CN111836812A (zh) 2018-03-07 2020-10-27 塞科里昂医疗股份有限公司 sGC刺激剂的晶型

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP7050759B2 (ja) 2016-09-02 2022-04-08 サイクレリオン・セラピューティクス，インコーポレーテッド 縮合二環式ｓｇｃ刺激剤

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EP3762389B1 (en) 2024-02-28
IL276853B1 (en) 2026-01-01
MA54638A (fr) 2021-11-10
CL2021003536A1 (es) 2022-08-19
KR102782810B1 (ko) 2025-03-14
WO2019173551A8 (en) 2020-06-11
CR20200458A (es) 2020-11-09
CO2020012493A2 (es) 2020-10-30
IL276853B2 (en) 2026-05-01
US20250115611A1 (en) 2025-04-10
AU2019231724A1 (en) 2020-10-08
TWI823903B (zh) 2023-12-01
CL2021000301A1 (es) 2021-06-18
TW201940487A (zh) 2019-10-16
EP3762389A1 (en) 2021-01-13
MX2020009183A (es) 2020-10-08
MX2023004857A (es) 2023-11-24
ES2980256T3 (es) 2024-09-30
CN111836812A (zh) 2020-10-27
US12122782B2 (en) 2024-10-22
IL276853A (en) 2020-10-29
PH12020551394A1 (en) 2021-11-22
CA3092683A1 (en) 2019-09-12
EA202092109A1 (ru) 2021-03-04
CL2020002284A1 (es) 2020-11-27
WO2019173551A1 (en) 2019-09-12
KR20200128708A (ko) 2020-11-16
MX2023004856A (es) 2023-11-24
PE20210124A1 (es) 2021-01-19
US11466015B2 (en) 2022-10-11
MX2023004855A (es) 2023-11-24
CL2021003530A1 (es) 2022-08-19
US20230095799A1 (en) 2023-03-30
MX2023004858A (es) 2023-11-24
BR112020018212A2 (pt) 2020-12-29
JP2021515015A (ja) 2021-06-17
AU2019231724B2 (en) 2024-06-27
CL2021003531A1 (es) 2022-08-19
SG11202008641WA (en) 2020-10-29
US20210115050A1 (en) 2021-04-22

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