JP7423539B2 - Ｓｇｃ刺激因子の結晶形態 - Google Patents

Ｓｇｃ刺激因子の結晶形態 Download PDF

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JP7423539B2
JP7423539B2 JP2020546378A JP2020546378A JP7423539B2 JP 7423539 B2 JP7423539 B2 JP 7423539B2 JP 2020546378 A JP2020546378 A JP 2020546378A JP 2020546378 A JP2020546378 A JP 2020546378A JP 7423539 B2 JP7423539 B2 JP 7423539B2
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fluorobenzyl
imidazo
trifluoromethyl
pyrazine
triazol
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JP2021515015A (ja
JP2021515015A5 (OSRAM
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ンティ－アデー，クワメ・ダブリュー
プラサード，リーナ・クマリ
ストルツ，トーマス
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ティセント セラピューティクス インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020546378A 2018-03-07 2019-03-07 Ｓｇｃ刺激因子の結晶形態 Active JP7423539B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862639846P 2018-03-07 2018-03-07
US62/639,846 2018-03-07
PCT/US2019/021080 WO2019173551A1 (en) 2018-03-07 2019-03-07 Crystalline forms of an sgc stimulator

Publications (3)

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JP2021515015A JP2021515015A (ja) 2021-06-17
JP2021515015A5 JP2021515015A5 (OSRAM) 2022-03-14
JP7423539B2 true JP7423539B2 (ja) 2024-01-29

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JP2020546378A Active JP7423539B2 (ja) 2018-03-07 2019-03-07 Ｓｇｃ刺激因子の結晶形態

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US (3) US11466015B2 (OSRAM)
EP (1) EP3762389B1 (OSRAM)
JP (1) JP7423539B2 (OSRAM)
KR (1) KR102782810B1 (OSRAM)
CN (1) CN111836812A (OSRAM)
AU (1) AU2019231724B2 (OSRAM)
BR (1) BR112020018212A2 (OSRAM)
CA (1) CA3092683A1 (OSRAM)
CL (5) CL2020002284A1 (OSRAM)
CO (1) CO2020012493A2 (OSRAM)
CR (1) CR20200458A (OSRAM)
EA (1) EA202092109A1 (OSRAM)
ES (1) ES2980256T3 (OSRAM)
IL (1) IL276853B2 (OSRAM)
MA (1) MA54638A (OSRAM)
MX (5) MX2023004856A (OSRAM)
PE (1) PE20210124A1 (OSRAM)
PH (1) PH12020551394A1 (OSRAM)
SG (1) SG11202008641WA (OSRAM)
TW (1) TWI823903B (OSRAM)
WO (1) WO2019173551A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3092683A1 (en) 2018-03-07 2019-09-12 Cyclerion Therapeutics, Inc. Crystalline forms of an sgc stimulator
JP7542518B2 (ja) * 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用
WO2021195403A1 (en) * 2020-03-26 2021-09-30 Cyclerion Therapeutics, Inc. Deuterated sgc stimulators
WO2024131860A1 (zh) * 2022-12-21 2024-06-27 广东东阳光药业股份有限公司 氟取代的吲唑化合物的晶型及其用途
AU2023412228A1 (en) * 2022-12-21 2025-07-03 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
JP7050759B2 (ja) 2016-09-02 2022-04-08 サイクレリオン・セラピューティクス，インコーポレーテッド 縮合二環式ｓｇｃ刺激剤

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JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
KR100720844B1 (ko) 1998-07-08 2007-05-25 사노피-아벤티스 도이칠란트 게엠베하 황 치환된 설포닐아미노카복실산 ｎ-아릴아미드, 이의 제조방법, 및 이를 함유하는 약제학적 제제
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
CA2698332C (en) 2007-09-06 2012-08-21 Merck Sharp & Dohme Corp. Pyrazole derivatives as soluble guanylate cyclase activators
US7947664B2 (en) 2008-01-24 2011-05-24 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
US8741910B2 (en) 2008-11-25 2014-06-03 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN102414194A (zh) 2009-02-26 2012-04-11 默沙东公司 可溶性鸟苷酸环化酶激活剂
WO2011119518A1 (en) 2010-03-25 2011-09-29 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
MA34330B1 (fr) 2010-05-27 2013-06-01 Merck Sharp & Dohme Activateurs de guanylate cyclase soluble
WO2012003405A1 (en) 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
NZ609955A (en) 2010-11-09 2015-05-29 Ironwood Pharmaceuticals Inc Sgc stimulators
CN104822680B (zh) 2012-11-30 2016-10-12 安斯泰来制药株式会社 咪唑并吡啶化合物
CN105339368B (zh) 2013-06-04 2017-08-15 拜耳制药股份公司 3‑芳基‑取代的咪唑并[1,2‑a]吡啶及其用途
CA2961489A1 (en) 2014-09-17 2016-03-24 Glen Robert RENNIE Sgc stimulators
CN107257796A (zh) 2014-12-02 2017-10-17 拜耳医药股份有限公司 取代的吡唑并[1,5‑a]吡啶和咪唑并[1,2‑a]吡嗪及其用途
CA3092683A1 (en) 2018-03-07 2019-09-12 Cyclerion Therapeutics, Inc. Crystalline forms of an sgc stimulator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP7050759B2 (ja) 2016-09-02 2022-04-08 サイクレリオン・セラピューティクス，インコーポレーテッド 縮合二環式ｓｇｃ刺激剤

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CR20200458A (es) 2020-11-09
BR112020018212A2 (pt) 2020-12-29
CA3092683A1 (en) 2019-09-12
JP2021515015A (ja) 2021-06-17
CL2020002284A1 (es) 2020-11-27
TWI823903B (zh) 2023-12-01
WO2019173551A1 (en) 2019-09-12
US11466015B2 (en) 2022-10-11
EA202092109A1 (ru) 2021-03-04
US20250115611A1 (en) 2025-04-10
MX2023004858A (es) 2023-11-24
MX2023004857A (es) 2023-11-24
TW201940487A (zh) 2019-10-16
KR102782810B1 (ko) 2025-03-14
CL2021000301A1 (es) 2021-06-18
KR20200128708A (ko) 2020-11-16
PH12020551394A1 (en) 2021-11-22
AU2019231724A1 (en) 2020-10-08
CN111836812A (zh) 2020-10-27
CL2021003531A1 (es) 2022-08-19
US12122782B2 (en) 2024-10-22
PE20210124A1 (es) 2021-01-19
CL2021003536A1 (es) 2022-08-19
MA54638A (fr) 2021-11-10
MX2023004855A (es) 2023-11-24
EP3762389A1 (en) 2021-01-13
WO2019173551A8 (en) 2020-06-11
US20210115050A1 (en) 2021-04-22
AU2019231724B2 (en) 2024-06-27
MX2023004856A (es) 2023-11-24
SG11202008641WA (en) 2020-10-29
CO2020012493A2 (es) 2020-10-30
EP3762389B1 (en) 2024-02-28
IL276853B1 (en) 2026-01-01
IL276853A (en) 2020-10-29
US20230095799A1 (en) 2023-03-30
CL2021003530A1 (es) 2022-08-19
MX2020009183A (es) 2020-10-08
ES2980256T3 (es) 2024-09-30
IL276853B2 (en) 2026-05-01

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