JP7422666B2 - 睡眠時無呼吸を治療するための方法および組成物 - Google Patents

睡眠時無呼吸を治療するための方法および組成物 Download PDF

Info

Publication number
JP7422666B2
JP7422666B2 JP2020542075A JP2020542075A JP7422666B2 JP 7422666 B2 JP7422666 B2 JP 7422666B2 JP 2020542075 A JP2020542075 A JP 2020542075A JP 2020542075 A JP2020542075 A JP 2020542075A JP 7422666 B2 JP7422666 B2 JP 7422666B2
Authority
JP
Japan
Prior art keywords
oxybutynin
composition
atomoxetine
enantiomeric excess
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020542075A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021516218A (ja
Inventor
ジー. ミラー,ローレンス
ウォール,バリー
ジェイ. ルンスマン,ウォルター
Original Assignee
アプニメッド,インコーポレイテッド(デラウェア)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプニメッド,インコーポレイテッド(デラウェア) filed Critical アプニメッド,インコーポレイテッド(デラウェア)
Publication of JP2021516218A publication Critical patent/JP2021516218A/ja
Priority to JP2023183525A priority Critical patent/JP2023181322A/ja
Application granted granted Critical
Publication of JP7422666B2 publication Critical patent/JP7422666B2/ja
Priority to JP2025138640A priority patent/JP2025159230A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2020542075A 2018-01-30 2019-01-30 睡眠時無呼吸を治療するための方法および組成物 Active JP7422666B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023183525A JP2023181322A (ja) 2018-01-30 2023-10-25 睡眠時無呼吸を治療するための方法および組成物
JP2025138640A JP2025159230A (ja) 2018-01-30 2025-08-22 睡眠時無呼吸を治療するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862623892P 2018-01-30 2018-01-30
US62/623,892 2018-01-30
PCT/US2019/015781 WO2019152475A1 (en) 2018-01-30 2019-01-30 Methods and compositions for treating sleep apnea

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023183525A Division JP2023181322A (ja) 2018-01-30 2023-10-25 睡眠時無呼吸を治療するための方法および組成物

Publications (2)

Publication Number Publication Date
JP2021516218A JP2021516218A (ja) 2021-07-01
JP7422666B2 true JP7422666B2 (ja) 2024-01-26

Family

ID=65441079

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020542075A Active JP7422666B2 (ja) 2018-01-30 2019-01-30 睡眠時無呼吸を治療するための方法および組成物
JP2023183525A Pending JP2023181322A (ja) 2018-01-30 2023-10-25 睡眠時無呼吸を治療するための方法および組成物
JP2025138640A Pending JP2025159230A (ja) 2018-01-30 2025-08-22 睡眠時無呼吸を治療するための方法および組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023183525A Pending JP2023181322A (ja) 2018-01-30 2023-10-25 睡眠時無呼吸を治療するための方法および組成物
JP2025138640A Pending JP2025159230A (ja) 2018-01-30 2025-08-22 睡眠時無呼吸を治療するための方法および組成物

Country Status (27)

Country Link
US (6) US11911351B2 (https=)
EP (2) EP3746126B1 (https=)
JP (3) JP7422666B2 (https=)
KR (2) KR102874891B1 (https=)
CN (2) CN111670050A (https=)
AU (2) AU2019214891B2 (https=)
BR (1) BR112020015316A2 (https=)
CA (1) CA3089712A1 (https=)
DK (1) DK3746126T3 (https=)
EA (1) EA202091597A1 (https=)
ES (1) ES2991425T3 (https=)
FI (1) FI3746126T3 (https=)
HR (1) HRP20241412T1 (https=)
HU (1) HUE068505T2 (https=)
IL (1) IL276247A (https=)
LT (1) LT3746126T (https=)
MA (1) MA52861B1 (https=)
MD (1) MD3746126T2 (https=)
MX (2) MX2020008086A (https=)
PL (1) PL3746126T3 (https=)
PT (1) PT3746126T (https=)
RS (1) RS66104B1 (https=)
SG (1) SG11202007226UA (https=)
SI (1) SI3746126T1 (https=)
SM (1) SMT202400400T1 (https=)
UA (1) UA129618C2 (https=)
WO (1) WO2019152475A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEAP202416602A (en) * 2017-04-28 2024-10-10 Brigham & Womens Hospital Inc Methods and compositions for treating sleep apnea
CN118557736A (zh) 2019-02-08 2024-08-30 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物
US20220362221A1 (en) * 2019-11-04 2022-11-17 Apnimed, Inc. (Delaware) Combination pharmacological interventions for multiple mechanisms of obstructive sleep apnea
WO2022069250A1 (en) 2020-09-30 2022-04-07 Koninklijke Philips N.V. Methods and systems for performing dose titration
AU2022231133A1 (en) * 2021-03-04 2023-09-21 Apnimed, Inc. (Delaware) Combination of reboxetine and a muscarinic receptor antagonist (mra) for use in treating sleep apnea
WO2022204228A1 (en) * 2021-03-24 2022-09-29 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
EP4334281A1 (en) 2021-05-04 2024-03-13 Apnimed, Inc. (Delaware) Solid forms of (r)-oxybutynin d-malate
US20240277719A1 (en) * 2021-06-17 2024-08-22 Apnimed, Inc. (Delaware) Norepinephrine reuptake inhibitors for treating sleep apnea
KR20240124995A (ko) 2021-12-22 2024-08-19 바이엘 악티엔게젤샤프트 수면 무호흡의 치료를 위한 a2-아드레날린수용체 하위유형 c (알파-2c) 길항제와 노르에피네프린 재흡수 억제제의 조합물
CA3259602A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of an .alpha.2-adrenoceptor subtype c (alpha-2c) antagonists with a muscarinic receptor antagonist for the treatment of sleep apnea
EP4522149A1 (en) * 2022-05-13 2025-03-19 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
KR20250000641A (ko) * 2023-06-27 2025-01-03 주식회사 아스트로젠 수면장애 및/또는 수면장애 관련 질환을 예방, 개선 또는 치료하는 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523382A (ja) 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
JP2012176958A (ja) 2012-04-20 2012-09-13 Watson Pharmaceuticals Inc (r)−オキシブチニンおよび(r)−デスエチルオキシブチニンによる平滑筋機能亢進の処置
JP2020517719A (ja) 2017-04-28 2020-06-18 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 睡眠時無呼吸を治療する方法及び組成物

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL124473C (https=) 1960-07-26
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE69636393T2 (de) 1995-10-24 2006-12-07 Grünenthal GmbH Montirelin zur verhinderung der schlafapnoe
US20020155113A1 (en) 2001-03-13 2002-10-24 Miyoung Chun Methods for treating or preventing cardiovascular disorders by modulating metalloprotease function
US20030060513A1 (en) 2001-09-27 2003-03-27 Arneric Stephen P. Pharmaceutical composition
US20030185882A1 (en) * 2001-11-06 2003-10-02 Vergez Juan A. Pharmaceutical compositions containing oxybutynin
US20040235925A1 (en) 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
JP2006524708A (ja) 2003-04-25 2006-11-02 インディヴァス ファーマシューティカルズ,インコーポレーテッド 塩化トロスピウムの投与により連続睡眠を促進するための方法
PT1696931E (pt) 2003-12-22 2009-06-12 Acadia Pharm Inc Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
US20060039866A1 (en) 2004-08-20 2006-02-23 Cypress Bioscience, Inc. Method for treating sleep-related breathing disorders
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1827450A4 (en) 2004-11-17 2009-04-22 Cypress Bioscience Inc METHOD FOR REDUCING THE SIDE EFFECTS OF TREATMENT WITH MIRTAZAPINE
CN101132777A (zh) 2004-12-20 2008-02-27 科利吉姆制药公司 用于睡眠障碍的药物组合物
US20080009538A1 (en) 2005-03-21 2008-01-10 Phil Skolnick Methods and compositions for the treatment of urinary incontinence
CA2603920A1 (en) 2005-04-15 2006-10-26 The Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
US20070021927A1 (en) 2005-07-21 2007-01-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Selective resonance of chemical structures
FR2889811B1 (fr) 2005-08-19 2009-10-09 Sanofi Aventis Sa Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique.
PL2083811T3 (pl) 2006-11-22 2017-05-31 Clinical Research Associates, Llc Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu
WO2008122019A1 (en) 2007-04-02 2008-10-09 Cypress Biosciences, Inc. Improving the tolerability of both mirtazapine and reboxetine by using them in combination
EP2142183A2 (en) 2007-04-09 2010-01-13 Sepracor Inc. Methods and compositions comprising desvenlafaxine or duloxetine for treating sleep-related breathing disorders
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US20090048233A1 (en) 2007-08-16 2009-02-19 Cypress Biosciences, Inc. Enhancing the Tolerability of a Seratonin Antagonist and a NSRI, a SNRI or a RIMA by Using Them in Combination
AR069875A1 (es) 2007-12-21 2010-02-24 Eurand Inc Composiciones de temazepam para tabletas de desintegracion oral y metodo de preparacion
US20100204058A1 (en) 2009-01-28 2010-08-12 Howard Yuan-Hao Chang Profiling for Determination of Response to Treatment for Inflammatory Disease
EP2552205A4 (en) 2010-04-01 2014-01-01 Theravida Inc PROCESS FOR INCREASING SLEEP QUALITY
JP2014503593A (ja) 2011-01-28 2014-02-13 ファンタスティック・メディカル・リサーチ・インスティテュート・エルエルシー 閉塞性睡眠時無呼吸を処置するための方法
DK2964185T3 (da) 2013-03-05 2022-02-14 Requis Pharmaceuticals Inc Præparater til behandlingen af søvnrelaterede luftvejslidelser
US20170304286A1 (en) 2014-10-24 2017-10-26 Launx Biomedical Co., Ltd. New indication of paroxetine pharmaceutical composition for treating cancer
MX373319B (es) 2015-04-27 2020-06-13 Arena Pharm Inc Derivados de hexahidro-[1-4]diazepino[6,7,1-hi]indol-8-carboxamida como agonistas del receptor 5-ht2c y el uso de los mismos en el tratamiento de enfermedades relacionadas con dicho receptor.
ES2925951T3 (es) 2015-07-22 2022-10-20 John Hsu Composición que comprende un agente terapéutico y un estimulante respiratorio y métodos para su uso
WO2017031319A1 (en) 2015-08-18 2017-02-23 Massachusetts Institute Of Technology Noradrenergic drug treatment of obstructive sleep apnea
AR114350A1 (es) 2018-01-31 2020-08-26 Res Institute At Nationwide Children’S Hospital Terapia genética para la distrofia muscular de cinturas del tipo 2c
CN118557736A (zh) 2019-02-08 2024-08-30 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523382A (ja) 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
JP2012176958A (ja) 2012-04-20 2012-09-13 Watson Pharmaceuticals Inc (r)−オキシブチニンおよび(r)−デスエチルオキシブチニンによる平滑筋機能亢進の処置
JP2020517719A (ja) 2017-04-28 2020-06-18 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 睡眠時無呼吸を治療する方法及び組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Atomoxetine and Oxybutynin in Obstructive Sleep Apnea (ATOSA) / Study NCT02908529 on Date: January 17, 2018 (v3),ClinicalTrials.gov archive [online],U. S. National Library of Medicine,2018年01月17日,https://clinicaltrials.gov/ct2/history/NCT02908529?A=3&B=3&C=merged#StudyPageTop
The Journal of Pharmacology and Experimental Therapeutics,1991年,Vol.256, No.2,p.562-567

Also Published As

Publication number Publication date
US11911351B2 (en) 2024-02-27
RS66104B1 (sr) 2024-11-29
ES2991425T3 (es) 2024-12-03
KR20200115598A (ko) 2020-10-07
KR20250156197A (ko) 2025-10-31
MX2024001713A (es) 2024-02-20
EP4445951A3 (en) 2025-01-08
EP3746126B1 (en) 2024-07-31
CN118384147A (zh) 2024-07-26
JP2021516218A (ja) 2021-07-01
US20220378724A1 (en) 2022-12-01
JP2025159230A (ja) 2025-10-17
SMT202400400T1 (it) 2024-11-15
KR102874891B1 (ko) 2025-10-21
EP4445951A2 (en) 2024-10-16
HRP20241412T1 (hr) 2024-12-20
LT3746126T (lt) 2024-10-25
US20250186371A1 (en) 2025-06-12
UA129618C2 (uk) 2025-06-18
BR112020015316A2 (pt) 2020-12-08
US20210038541A1 (en) 2021-02-11
AU2019214891A1 (en) 2020-08-20
WO2019152475A1 (en) 2019-08-08
EA202091597A1 (ru) 2020-10-22
SI3746126T1 (sl) 2025-01-31
US20240390299A1 (en) 2024-11-28
MA52861A (fr) 2021-05-05
MA52861B1 (fr) 2024-09-30
JP2023181322A (ja) 2023-12-21
HUE068505T2 (hu) 2024-12-28
MX2020008086A (es) 2021-02-15
US20240156753A1 (en) 2024-05-16
IL276247A (en) 2020-09-30
AU2024227631A1 (en) 2024-11-14
CN111670050A (zh) 2020-09-15
SG11202007226UA (en) 2020-08-28
PT3746126T (pt) 2024-10-21
EP3746126A1 (en) 2020-12-09
FI3746126T3 (fi) 2024-10-10
AU2019214891B2 (en) 2024-08-01
US20260027070A1 (en) 2026-01-29
CA3089712A1 (en) 2019-08-08
PL3746126T3 (pl) 2024-12-16
DK3746126T3 (da) 2024-10-07
MD3746126T2 (ro) 2024-12-31
NZ766673A (en) 2025-08-29

Similar Documents

Publication Publication Date Title
JP7422666B2 (ja) 睡眠時無呼吸を治療するための方法および組成物
US20260007618A1 (en) Methods and compositions for treating sleep apnea
US20250114321A1 (en) Methods and compositions for treating sleep apnea
US20230135373A1 (en) Methods and compositions for treating sleep apnea
HK40117857A (en) Methods and compositions for treating sleep apnea
HK40120547A (zh) 用於治疗睡眠呼吸暂停的方法和组合物
HK40031779A (en) Methods and compositions for treating sleep apnea or simple snoring
HK40031779B (en) Methods and compositions for treating sleep apnea or simple snoring
HK40013951A (en) Methods and compositions for treating sleep apnea
OA19434A (en) Methods and compositions for treating sleep apnea.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210426

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220104

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20221021

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230502

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230727

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231025

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20231027

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20231116

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20231218

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240116

R150 Certificate of patent or registration of utility model

Ref document number: 7422666

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350