JP7418323B2 - 遠赤および近ｉｒ範囲におけるシアニンフルオロフォアの配座の束縛 - Google Patents

遠赤および近ｉｒ範囲におけるシアニンフルオロフォアの配座の束縛 Download PDF

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JP7418323B2
JP7418323B2 JP2020510560A JP2020510560A JP7418323B2 JP 7418323 B2 JP7418323 B2 JP 7418323B2 JP 2020510560 A JP2020510560 A JP 2020510560A JP 2020510560 A JP2020510560 A JP 2020510560A JP 7418323 B2 JP7418323 B2 JP 7418323B2
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JP2020531497A5 (enExample
JP2020531497A (ja
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マーティン ジェイ． シュナーマン，
メーガン エス． ミチー，
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US Department of Health and Human Services
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2020510560A 2017-08-24 2018-08-24 遠赤および近ｉｒ範囲におけるシアニンフルオロフォアの配座の束縛 Active JP7418323B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762549566P 2017-08-24 2017-08-24
US62/549,566 2017-08-24
PCT/US2018/047876 WO2019040825A1 (en) 2017-08-24 2018-08-24 CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN A FAR RED RANGE AND CLOSE INFRARED

Publications (3)

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JP2020531497A JP2020531497A (ja) 2020-11-05
JP2020531497A5 JP2020531497A5 (enExample) 2021-09-24
JP7418323B2 true JP7418323B2 (ja) 2024-01-19

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JP2020510560A Active JP7418323B2 (ja) 2017-08-24 2018-08-24 遠赤および近ｉｒ範囲におけるシアニンフルオロフォアの配座の束縛

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US (2) US10994029B2 (enExample)
EP (1) EP3655408B1 (enExample)
JP (1) JP7418323B2 (enExample)
WO (1) WO2019040825A1 (enExample)

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US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
US11130986B2 (en) 2015-05-20 2021-09-28 Quantum-Si Incorporated Method for isolating target nucleic acid using heteroduplex binding proteins
WO2018118997A2 (en) 2016-12-19 2018-06-28 Quantum-Si Incorporated Polymerizing enzymes for sequencing reactions
CA3059211A1 (en) 2017-05-05 2018-11-08 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
KR102626317B1 (ko) 2017-07-24 2024-01-18 퀀텀-에스아이 인코포레이티드 고강도 표지된 반응물 조성물 및 서열분석 방법
GB201715684D0 (en) 2017-09-28 2017-11-15 Univ Gent Means and methods for single molecule peptide sequencing
EP3752486A4 (en) 2018-02-15 2022-07-06 Children's National Medical Center Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems
EP3820943A1 (en) 2018-07-13 2021-05-19 Quantum-si Incorporated Biconjugatable labels and methods of use
WO2020041743A1 (en) 2018-08-23 2020-02-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Water soluble novel cyanine fluorophore with tunable properties between near ir and swir region for in vivo imaging
TWI863941B (zh) 2018-11-15 2024-12-01 美商寬騰矽公司 用於蛋白質定序之方法及組合物
CN113614097A (zh) 2019-01-23 2021-11-05 宽腾矽公司 高强度标记的反应物组合物和测序方法
EP3976771A1 (en) 2019-06-28 2022-04-06 Quantum-si Incorporated Polymerizing enzymes for sequencing reactions
KR102207333B1 (ko) * 2019-09-09 2021-01-27 성균관대학교산학협력단 4중 연속 고리 화합물의 신규한 제조방법
BR112022006682A2 (pt) 2019-10-11 2022-07-12 Quantum Si Inc Modificação de superfície na fase de vapor
WO2021086985A1 (en) 2019-10-29 2021-05-06 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
JP2023512634A (ja) 2020-01-21 2023-03-28 クアンタム－エスアイ インコーポレイテッド Ｃ末端の選択的標識のための化合物および方法
WO2021236983A2 (en) 2020-05-20 2021-11-25 Quantum-Si Incorporated Methods and compositions for protein sequencing
WO2021252639A1 (en) * 2020-06-09 2021-12-16 University Of Cincinnati Implantable device for organ operation modulation
WO2022139292A1 (ko) * 2020-12-21 2022-06-30 에스에프씨 주식회사 리포터 및 이의 용도
WO2023153739A1 (ko) * 2022-02-10 2023-08-17 에스에프씨 주식회사 신규한 화합물 및 이의 용도
WO2026052826A1 (en) 2024-09-09 2026-03-12 Roche Diagnostics Gmbh Methods for producing fluorescent dyes

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2002508428A (ja) 1997-12-17 2002-03-19 カーネギー メロン ユニヴァーシティ 硬化トリメチンシアニン色素
JP2005536623A (ja) 2002-05-10 2005-12-02 カーネギー・メロン・ユニヴァーシティ 官能基を含有するキラルインドール中間体およびそれらの蛍光シアニン染料

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US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
EP1163372A4 (en) 1999-03-24 2002-10-02 Princeton Separations CHEMICALLY REACTIVE CYANINE DYES AND DERIVATIVES IN A LEVEL
KR101158329B1 (ko) 2010-07-16 2012-06-22 충북대학교 산학협력단 자동 지폐 검사를 위한 형광 패턴 추출 장치 및 방법
US9349964B2 (en) 2010-12-24 2016-05-24 Lg Chem, Ltd. Organic light emitting diode and manufacturing method thereof
WO2012173369A2 (ko) 2011-06-13 2012-12-20 주식회사 엘지화학 신규한 화합물 및 이를 이용한 유기 전자 소자
WO2016072984A1 (en) 2014-11-05 2016-05-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A new class of stable heptamethine cyanine fluorophores and biomedical applications thereof
WO2017027721A1 (en) 2015-08-12 2017-02-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near-ir light-cleavable conjugates and conjugate precursors
JP7042254B2 (ja) 2016-08-11 2022-03-25 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 近赤外光開裂性コンジュゲートおよびコンジュゲート前駆体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508428A (ja) 1997-12-17 2002-03-19 カーネギー メロン ユニヴァーシティ 硬化トリメチンシアニン色素
JP2005536623A (ja) 2002-05-10 2005-12-02 カーネギー・メロン・ユニヴァーシティ 官能基を含有するキラルインドール中間体およびそれらの蛍光シアニン染料

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US11707537B2 (en) 2023-07-25
US10994029B2 (en) 2021-05-04
US20200179536A1 (en) 2020-06-11
US20210220490A1 (en) 2021-07-22
EP3655408B1 (en) 2021-07-14
WO2019040825A1 (en) 2019-02-28
EP3655408A1 (en) 2020-05-27
JP2020531497A (ja) 2020-11-05

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