JP7416622B2 - チオ硫酸ナトリウムの透析中の使用 - Google Patents
チオ硫酸ナトリウムの透析中の使用 Download PDFInfo
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- JP7416622B2 JP7416622B2 JP2019548683A JP2019548683A JP7416622B2 JP 7416622 B2 JP7416622 B2 JP 7416622B2 JP 2019548683 A JP2019548683 A JP 2019548683A JP 2019548683 A JP2019548683 A JP 2019548683A JP 7416622 B2 JP7416622 B2 JP 7416622B2
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- JP
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- Prior art keywords
- dialysate
- thiosulfate
- spiked
- pharmaceutical
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 claims description 78
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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| JP2025028476A JP2025084833A (ja) | 2017-03-08 | 2025-02-26 | チオ硫酸ナトリウムの透析中の使用 |
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| US201762468871P | 2017-03-08 | 2017-03-08 | |
| US62/468,871 | 2017-03-08 | ||
| PCT/US2018/021069 WO2018165108A1 (en) | 2017-03-08 | 2018-03-06 | Intradialytic use of sodium thiosulfate |
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| JP2020510680A JP2020510680A (ja) | 2020-04-09 |
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| IL268883B (en) | 2017-03-08 | 2022-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| CN112805238A (zh) | 2018-07-03 | 2021-05-14 | 芬内克制药股份有限公司 | 无水硫代硫酸钠和其调配物 |
| US11850313B2 (en) * | 2019-12-20 | 2023-12-26 | The London Health Sciences Centre Research Inc. | Method and compositions for protecting tissue |
| WO2024092228A2 (en) * | 2022-10-28 | 2024-05-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Localized delivery of sodium thiosulfate nanoparticles to mitigate arterial calcification |
| CN116573782B (zh) * | 2023-04-03 | 2023-11-03 | 迁安市宏奥工贸有限公司 | 脱硫废液的处理方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| JP2015516407A (ja) | 2012-05-10 | 2015-06-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 異所性石灰化の治療のためのチオ硫酸ナトリウム |
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| EP0218900B1 (en) | 1985-09-10 | 1992-01-22 | Research Corporation Technologies, Inc. | Osmotic agents for peritoneal dialysis |
| US5108767A (en) * | 1991-06-10 | 1992-04-28 | Abbott Laboratories | Liquid nutritional product for persons receiving renal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) * | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| ES2322689T3 (es) * | 1999-09-22 | 2009-06-25 | Advanced Renal Technologies | Uso de un dializado con elevado contenido de citrato. |
| US7022315B2 (en) * | 2000-04-26 | 2006-04-04 | Oregon Health & Science University | Administration of a thiol-based chemoprotectant compound |
| JP4882054B2 (ja) * | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
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| US20070154570A1 (en) | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7834065B2 (en) | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| AU2010270605B2 (en) | 2009-07-08 | 2014-07-31 | Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals | Sodium thiosulfate-containing pharmaceutical compositions |
| CA2844759A1 (en) | 2011-08-11 | 2013-02-14 | Nathan S. Bryan | Method of measuring and monitoring in vivo nitrite levels |
| WO2013112582A1 (en) | 2012-01-23 | 2013-08-01 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP5486069B1 (ja) * | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| WO2016094409A1 (en) * | 2014-12-09 | 2016-06-16 | Villarreal Anna | Methods and devices for female health monitoring |
| IL268883B (en) * | 2017-03-08 | 2022-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| BR112019018861A2 (pt) | 2017-03-08 | 2023-10-10 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Uso de nitrito de sódio, método para manter os níveis fisiológicos de nitrito, prevenir enfarte do miocárdio, prevenir morte súbita cardíaca, prevenir acidente vascular cerebral, doenças cardiovasculares, pressão alta, solução aquosa |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| JP2015516407A (ja) | 2012-05-10 | 2015-06-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 異所性石灰化の治療のためのチオ硫酸ナトリウム |
Non-Patent Citations (1)
| Title |
|---|
| Int J Artif Organs,2014年,Vol.37, No.4,pp.308-314 |
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| AU2024203603B2 (en) | Intradialytic use of sodium thiosulfate | |
| TWI915123B (zh) | 包含硫代硫酸鈉之醫藥組合物 | |
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