ES2992792T3 - Intradialytic use of sodium thiosulfate - Google Patents
Intradialytic use of sodium thiosulfate Download PDFInfo
- Publication number
- ES2992792T3 ES2992792T3 ES18764116T ES18764116T ES2992792T3 ES 2992792 T3 ES2992792 T3 ES 2992792T3 ES 18764116 T ES18764116 T ES 18764116T ES 18764116 T ES18764116 T ES 18764116T ES 2992792 T3 ES2992792 T3 ES 2992792T3
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- ES
- Spain
- Prior art keywords
- thiosulfate
- sodium thiosulfate
- dialysate
- enriched
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 title claims abstract description 212
- 235000019345 sodium thiosulphate Nutrition 0.000 title claims abstract description 209
- 238000000034 method Methods 0.000 claims abstract description 64
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims abstract 17
- 239000000243 solution Substances 0.000 claims description 87
- 238000000502 dialysis Methods 0.000 claims description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 49
- 239000007864 aqueous solution Substances 0.000 claims description 46
- 239000012528 membrane Substances 0.000 claims description 45
- 239000002253 acid Substances 0.000 claims description 43
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 42
- 239000008280 blood Substances 0.000 claims description 31
- 210000004369 blood Anatomy 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 25
- 201000001320 Atherosclerosis Diseases 0.000 claims description 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 8
- 208000020832 chronic kidney disease Diseases 0.000 claims description 8
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 8
- 208000010125 myocardial infarction Diseases 0.000 claims description 7
- 206010020772 Hypertension Diseases 0.000 claims description 6
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims description 6
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- 206010002383 Angina Pectoris Diseases 0.000 claims description 4
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 claims description 4
- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
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- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 claims description 4
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- 238000001631 haemodialysis Methods 0.000 abstract description 42
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- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 136
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 27
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 19
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- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 10
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- 239000003112 inhibitor Substances 0.000 description 10
- 229940124597 therapeutic agent Drugs 0.000 description 10
- 238000001514 detection method Methods 0.000 description 9
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 8
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
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- 229910052785 arsenic Inorganic materials 0.000 description 6
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 6
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762468871P | 2017-03-08 | 2017-03-08 | |
| PCT/US2018/021069 WO2018165108A1 (en) | 2017-03-08 | 2018-03-06 | Intradialytic use of sodium thiosulfate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2992792T3 true ES2992792T3 (en) | 2024-12-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18764116T Active ES2992792T3 (en) | 2017-03-08 | 2018-03-06 | Intradialytic use of sodium thiosulfate |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10744156B2 (https=) |
| EP (2) | EP4403215A3 (https=) |
| JP (3) | JP7416622B2 (https=) |
| KR (4) | KR20250007674A (https=) |
| AR (1) | AR111236A1 (https=) |
| AU (1) | AU2018231072B2 (https=) |
| CA (1) | CA3055107A1 (https=) |
| ES (1) | ES2992792T3 (https=) |
| IL (4) | IL268883B (https=) |
| NZ (4) | NZ788158A (https=) |
| PH (1) | PH12019501971A1 (https=) |
| TW (2) | TWI869743B (https=) |
| WO (1) | WO2018165108A1 (https=) |
| ZA (2) | ZA202105781B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL268883B (en) | 2017-03-08 | 2022-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| CN112805238A (zh) | 2018-07-03 | 2021-05-14 | 芬内克制药股份有限公司 | 无水硫代硫酸钠和其调配物 |
| US11850313B2 (en) * | 2019-12-20 | 2023-12-26 | The London Health Sciences Centre Research Inc. | Method and compositions for protecting tissue |
| WO2024092228A2 (en) * | 2022-10-28 | 2024-05-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Localized delivery of sodium thiosulfate nanoparticles to mitigate arterial calcification |
| CN116573782B (zh) * | 2023-04-03 | 2023-11-03 | 迁安市宏奥工贸有限公司 | 脱硫废液的处理方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0218900B1 (en) | 1985-09-10 | 1992-01-22 | Research Corporation Technologies, Inc. | Osmotic agents for peritoneal dialysis |
| US5108767A (en) * | 1991-06-10 | 1992-04-28 | Abbott Laboratories | Liquid nutritional product for persons receiving renal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) * | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| ES2322689T3 (es) * | 1999-09-22 | 2009-06-25 | Advanced Renal Technologies | Uso de un dializado con elevado contenido de citrato. |
| US7022315B2 (en) * | 2000-04-26 | 2006-04-04 | Oregon Health & Science University | Administration of a thiol-based chemoprotectant compound |
| JP4882054B2 (ja) * | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| WO2006001345A1 (ja) | 2004-06-23 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | Ｌ－リジン・クエン酸塩結晶 |
| US20070154570A1 (en) | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7834065B2 (en) | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| AU2010270605B2 (en) | 2009-07-08 | 2014-07-31 | Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals | Sodium thiosulfate-containing pharmaceutical compositions |
| CA2844759A1 (en) | 2011-08-11 | 2013-02-14 | Nathan S. Bryan | Method of measuring and monitoring in vivo nitrite levels |
| WO2013112582A1 (en) | 2012-01-23 | 2013-08-01 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| US9629872B2 (en) * | 2012-05-10 | 2017-04-25 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Sodium thiosulphate for the treatment of ectopic calcifications |
| JP5486069B1 (ja) * | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| WO2016094409A1 (en) * | 2014-12-09 | 2016-06-16 | Villarreal Anna | Methods and devices for female health monitoring |
| IL268883B (en) * | 2017-03-08 | 2022-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| BR112019018861A2 (pt) | 2017-03-08 | 2023-10-10 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Uso de nitrito de sódio, método para manter os níveis fisiológicos de nitrito, prevenir enfarte do miocárdio, prevenir morte súbita cardíaca, prevenir acidente vascular cerebral, doenças cardiovasculares, pressão alta, solução aquosa |
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2018
- 2018-03-06 IL IL268883A patent/IL268883B/en unknown
- 2018-03-06 WO PCT/US2018/021069 patent/WO2018165108A1/en not_active Ceased
- 2018-03-06 ES ES18764116T patent/ES2992792T3/es active Active
- 2018-03-06 EP EP24181083.7A patent/EP4403215A3/en active Pending
- 2018-03-06 KR KR1020247041494A patent/KR20250007674A/ko active Pending
- 2018-03-06 NZ NZ788158A patent/NZ788158A/en unknown
- 2018-03-06 NZ NZ756704A patent/NZ756704A/en unknown
- 2018-03-06 KR KR1020247030238A patent/KR102758644B1/ko active Active
- 2018-03-06 KR KR1020197029238A patent/KR102647836B1/ko active Active
- 2018-03-06 KR KR1020247008181A patent/KR102706439B1/ko active Active
- 2018-03-06 IL IL302827A patent/IL302827B2/en unknown
- 2018-03-06 IL IL312724A patent/IL312724A/en unknown
- 2018-03-06 IL IL295119A patent/IL295119B2/en unknown
- 2018-03-06 NZ NZ797802A patent/NZ797802A/en unknown
- 2018-03-06 JP JP2019548683A patent/JP7416622B2/ja active Active
- 2018-03-06 CA CA3055107A patent/CA3055107A1/en active Pending
- 2018-03-06 EP EP18764116.2A patent/EP3592824B1/en active Active
- 2018-03-06 NZ NZ797803A patent/NZ797803A/en unknown
- 2018-03-06 AU AU2018231072A patent/AU2018231072B2/en active Active
- 2018-03-07 US US15/914,661 patent/US10744156B2/en active Active
- 2018-03-07 AR ARP180100530A patent/AR111236A1/es not_active Application Discontinuation
- 2018-03-07 TW TW111149188A patent/TWI869743B/zh active
- 2018-03-07 TW TW107107748A patent/TWI789378B/zh active
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2019
- 2019-08-28 PH PH12019501971A patent/PH12019501971A1/en unknown
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2020
- 2020-07-13 US US16/927,901 patent/US11116790B2/en active Active
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2021
- 2021-08-09 US US17/397,353 patent/US11779596B2/en active Active
- 2021-08-13 ZA ZA2021/05781A patent/ZA202105781B/en unknown
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2022
- 2022-08-15 ZA ZA2022/09104A patent/ZA202209104B/en unknown
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2023
- 2023-08-29 US US18/239,405 patent/US12370212B2/en active Active
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2024
- 2024-01-04 JP JP2024000105A patent/JP7642878B2/ja active Active
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2025
- 2025-02-26 JP JP2025028476A patent/JP2025084833A/ja active Pending
- 2025-07-02 US US19/258,074 patent/US20250332194A1/en active Pending
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