JP7410139B2 - 癌治療のための修飾ｂ５ｒ遺伝子を有する腫瘍溶解性ワクシニアウイルス - Google Patents

癌治療のための修飾ｂ５ｒ遺伝子を有する腫瘍溶解性ワクシニアウイルス Download PDF

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JP7410139B2
JP7410139B2 JP2021519114A JP2021519114A JP7410139B2 JP 7410139 B2 JP7410139 B2 JP 7410139B2 JP 2021519114 A JP2021519114 A JP 2021519114A JP 2021519114 A JP2021519114 A JP 2021519114A JP 7410139 B2 JP7410139 B2 JP 7410139B2
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vaccinia virus
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ヤオヘ ワン
ミング ユアン
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クイーン マリー ユニバーシティ オブ ロンドン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • C—CHEMISTRY; METALLURGY
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/5434—IL-12
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Wood Science & Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021519114A 2018-10-10 2019-10-10 癌治療のための修飾ｂ５ｒ遺伝子を有する腫瘍溶解性ワクシニアウイルス Active JP7410139B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1816547.2A GB201816547D0 (en) 2018-10-10 2018-10-10 Oncolytic virus for the treatment of cancer
GB1816547.2 2018-10-10
PCT/GB2019/052877 WO2020074902A1 (en) 2018-10-10 2019-10-10 Oncolytic vaccinia virus with modified b5r gene for the treatment of cancer

Publications (4)

Publication Number Publication Date
JP2022502066A JP2022502066A (ja) 2022-01-11
JPWO2020074902A5 JPWO2020074902A5 (https=) 2022-10-04
JP2022502066A5 JP2022502066A5 (https=) 2022-10-04
JP7410139B2 true JP7410139B2 (ja) 2024-01-09

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JP2021519114A Active JP7410139B2 (ja) 2018-10-10 2019-10-10 癌治療のための修飾ｂ５ｒ遺伝子を有する腫瘍溶解性ワクシニアウイルス

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US (1) US12509704B2 (https=)
EP (1) EP3863669A1 (https=)
JP (1) JP7410139B2 (https=)
KR (1) KR102937548B1 (https=)
CN (1) CN113453713A (https=)
CA (1) CA3123973A1 (https=)
GB (1) GB201816547D0 (https=)
WO (1) WO2020074902A1 (https=)

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WO2025184411A1 (en) 2024-02-27 2025-09-04 Calidi Biotherapeutics (Nevada), Inc. Serum-resistant eev viruses and uses thereof

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US20170340687A1 (en) 2016-05-30 2017-11-30 Astellas Pharma Inc. Novel genetically engineered vaccinia viruses

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KR20210102196A (ko) 2021-08-19
KR102937548B1 (ko) 2026-03-11
JP2022502066A (ja) 2022-01-11
GB201816547D0 (en) 2018-11-28
WO2020074902A1 (en) 2020-04-16
US12509704B2 (en) 2025-12-30
CA3123973A1 (en) 2020-04-16
US20210332384A1 (en) 2021-10-28
EP3863669A1 (en) 2021-08-18
CN113453713A (zh) 2021-09-28

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