CN113453713A - 用于治疗癌症的具有修饰的b5r基因的溶瘤痘苗病毒 - Google Patents

用于治疗癌症的具有修饰的b5r基因的溶瘤痘苗病毒 Download PDF

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CN113453713A
CN113453713A CN201980081698.5A CN201980081698A CN113453713A CN 113453713 A CN113453713 A CN 113453713A CN 201980081698 A CN201980081698 A CN 201980081698A CN 113453713 A CN113453713 A CN 113453713A
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vaccinia virus
gene
virus
virus vector
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王尧河
袁明
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Queen Mary University of London
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    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980081698.5A 2018-10-10 2019-10-10 用于治疗癌症的具有修饰的b5r基因的溶瘤痘苗病毒 Pending CN113453713A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1816547.2A GB201816547D0 (en) 2018-10-10 2018-10-10 Oncolytic virus for the treatment of cancer
GB1816547.2 2018-10-10
PCT/GB2019/052877 WO2020074902A1 (en) 2018-10-10 2019-10-10 Oncolytic vaccinia virus with modified b5r gene for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN113453713A true CN113453713A (zh) 2021-09-28

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CN201980081698.5A Pending CN113453713A (zh) 2018-10-10 2019-10-10 用于治疗癌症的具有修饰的b5r基因的溶瘤痘苗病毒

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US (1) US12509704B2 (https=)
EP (1) EP3863669A1 (https=)
JP (1) JP7410139B2 (https=)
KR (1) KR102937548B1 (https=)
CN (1) CN113453713A (https=)
CA (1) CA3123973A1 (https=)
GB (1) GB201816547D0 (https=)
WO (1) WO2020074902A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119923267A (zh) * 2022-07-27 2025-05-02 阿斯利康(瑞典)有限公司 表达白介素-12的重组病毒与pd-1/pd-l1抑制剂的组合
WO2025184411A1 (en) 2024-02-27 2025-09-04 Calidi Biotherapeutics (Nevada), Inc. Serum-resistant eev viruses and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170020938A1 (en) * 2014-04-01 2017-01-26 Queen Mary University Of London Oncolytic Vaccinia Virus
US20170340687A1 (en) * 2016-05-30 2017-11-30 Astellas Pharma Inc. Novel genetically engineered vaccinia viruses
WO2018049261A1 (en) * 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364773A (en) 1991-03-07 1994-11-15 Virogenetics Corporation Genetically engineered vaccine strain
US5547862A (en) 1993-07-29 1996-08-20 Ambion Inc. Vectors containing multiple promoters in the same orientation
FR2757178B1 (fr) 1996-12-13 1999-03-05 Centre Nat Rech Scient Utilisation d'un vecteur exprimant l'adn polymerase beta comme medicament
US5955310A (en) 1998-02-26 1999-09-21 Novo Nordisk Biotech, Inc. Methods for producing a polypeptide in a bacillus cell
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
KR100354441B1 (en) 2000-12-27 2002-09-28 Samsung Electronics Co Ltd Method for fabricating spin-on-glass insulation layer of semiconductor device
CA2481304A1 (en) 2002-03-27 2003-10-09 Patrick Hwu Method for treating cancer in humans
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20090148527A1 (en) 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
CA2558771C (en) 2004-03-05 2013-01-08 Benitec, Inc. Multiple promoter expression cassettes for simultaneous delivery of rnai agents
KR101772375B1 (ko) 2005-09-07 2017-08-29 신라젠(주) Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
BRPI0618441B8 (pt) 2005-11-10 2021-07-27 Genvec Inc vetor adenoviral
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US7741273B2 (en) 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
EP2097517B1 (en) 2006-10-16 2014-06-04 Genelux Corporation Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US20090196905A1 (en) 2008-02-06 2009-08-06 Spada Lon T Stabilization of mitochondrial membranes in ocular diseases and conditions
CN101658670A (zh) 2008-08-25 2010-03-03 中国疾病预防控制中心性病艾滋病预防控制中心 基于n1l和b8r基因缺失的痘苗病毒载体的艾滋病疫苗
ES2585242T3 (es) * 2008-09-19 2016-10-04 Etat Francais Représenté Par Le Directeur Central Du Service De Santé Des Armées Cepas virales obtenidas del virus vaccinia Lister VACV-107 y usos de las mismas
EP2199400A1 (en) 2008-12-22 2010-06-23 Emergent Product Development Germany GmbH Single recombination system and methods of use
US20100291182A1 (en) 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
EP2432420A4 (en) 2009-05-18 2018-01-10 Dose Medical Corporation Drug eluting ocular implant
US8580276B2 (en) 2009-06-05 2013-11-12 City Of Hope Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof
ES2362525B8 (es) 2009-10-08 2013-01-03 Azurebio, S.L. Formulación de medicamentos en forma de agujas percutaneas penetrantes.
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US20130071430A1 (en) 2010-04-09 2013-03-21 The University Of Tokyo Microrna-controlled recombinant vaccinia virus and use thereof
JP5996544B2 (ja) 2010-10-15 2016-09-21 クリアサイド・バイオメディカル・インコーポレーテッドＣｌｅａｒｓｉｄｅ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ 眼球アクセス用装置
EP2654715B1 (en) 2010-11-24 2017-01-25 Dose Medical Corporation Drug eluting ocular implant
CN103261420B (zh) 2010-12-16 2016-01-20 诺维信股份有限公司 用于在真菌细胞中表达基因的启动子
CN103110939A (zh) 2012-10-23 2013-05-22 郑州大学 诱导肿瘤特异性免疫的疫苗及其应用
AU2014248460B2 (en) 2013-04-01 2019-04-11 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
WO2017014296A1 (ja) * 2015-07-22 2017-01-26 国立大学法人鳥取大学 ワクシニアウイルスの増殖・伝搬を増強する宿主制御因子

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170020938A1 (en) * 2014-04-01 2017-01-26 Queen Mary University Of London Oncolytic Vaccinia Virus
CN106795527A (zh) * 2014-04-01 2017-05-31 玛丽女王伦敦大学 溶瘤病毒
US20170340687A1 (en) * 2016-05-30 2017-11-30 Astellas Pharma Inc. Novel genetically engineered vaccinia viruses
WO2018049261A1 (en) * 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELIZABETH MATHEW 等: "The extracellular domain of vaccinia virus protein B5R affects plague phenotype, extracellualr enveloped virus release, and intracellular actin tail formation", JOURNAL OF VIROLOGY, vol. 72, no. 3, pages 2430 *

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Publication number Publication date
JP7410139B2 (ja) 2024-01-09
KR20210102196A (ko) 2021-08-19
JP2022502066A (ja) 2022-01-11
GB201816547D0 (en) 2018-11-28
KR102937548B1 (ko) 2026-03-11
US20210332384A1 (en) 2021-10-28
EP3863669A1 (en) 2021-08-18
US12509704B2 (en) 2025-12-30
CA3123973A1 (en) 2020-04-16
WO2020074902A1 (en) 2020-04-16

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