JP7408389B2 - 真核細胞の増殖制御方法 - Google Patents

真核細胞の増殖制御方法 Download PDF

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JP7408389B2
JP7408389B2 JP2019530766A JP2019530766A JP7408389B2 JP 7408389 B2 JP7408389 B2 JP 7408389B2 JP 2019530766 A JP2019530766 A JP 2019530766A JP 2019530766 A JP2019530766 A JP 2019530766A JP 7408389 B2 JP7408389 B2 JP 7408389B2
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cell density
time
target
tank
control logic
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JP2020504601A (ja
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クリスティアン ハーケマイヤー
ハイノ ビュンテマイヤー
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019530766A 2016-12-21 2017-12-20 真核細胞の増殖制御方法 Active JP7408389B2 (ja)

Priority Applications (1)

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JP2022144236A JP2022177117A (ja) 2016-12-21 2022-09-12 真核細胞の増殖制御方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16205982.8 2016-12-21
EP16205982 2016-12-21
PCT/EP2017/083886 WO2018115161A1 (en) 2016-12-21 2017-12-20 Growth control of eukaryotic cells

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JP2022144236A Division JP2022177117A (ja) 2016-12-21 2022-09-12 真核細胞の増殖制御方法

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JP2020504601A JP2020504601A (ja) 2020-02-13
JP7408389B2 true JP7408389B2 (ja) 2024-01-05

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JP2019530766A Active JP7408389B2 (ja) 2016-12-21 2017-12-20 真核細胞の増殖制御方法
JP2022144236A Pending JP2022177117A (ja) 2016-12-21 2022-09-12 真核細胞の増殖制御方法

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US (1) US20200063086A1 (pl)
EP (1) EP3559203B1 (pl)
JP (2) JP7408389B2 (pl)
CN (1) CN110023482B (pl)
ES (1) ES2848701T3 (pl)
HR (1) HRP20210163T1 (pl)
PL (1) PL3559203T3 (pl)
SI (1) SI3559203T1 (pl)
WO (1) WO2018115161A1 (pl)

Families Citing this family (8)

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WO2020041454A1 (en) * 2018-08-21 2020-02-27 Lonza Ltd A process for creating reference data for predicting concentrations of quality attributes
US10775395B2 (en) * 2018-10-18 2020-09-15 Arctoris Limited System and method of performing a biological experiment with adaptive cybernetic control of procedural conditions
EP3699261A1 (en) * 2019-02-20 2020-08-26 Sartorius Stedim Biotech GmbH Bioprocess device assembly and inoculation method
JP7210355B2 (ja) * 2019-03-27 2023-01-23 株式会社エビデント 細胞観察システム、コロニー生成位置推定方法、推論モデル生成方法、およびプログラム
JP2020162549A (ja) * 2019-03-29 2020-10-08 味の素株式会社 制御装置、制御方法およびプログラムならびに有機化合物の製造方法
BR112022007624A2 (pt) * 2019-10-25 2022-07-12 Regeneron Pharma Sistema para controlar um processo de trem de sementes, e, método de autoinoculação de um biorreator
US20240182843A1 (en) * 2022-12-02 2024-06-06 Vanderbil University Variable-volume chemostat and applications thereof
JP2024081079A (ja) * 2022-12-05 2024-06-17 横河電機株式会社 細胞培養制御システム、細胞培養制御方法及び細胞培養制御プログラム

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003235544A (ja) 2002-02-20 2003-08-26 Hitachi Ltd 生体細胞の培養制御方法及び培養装置の制御装置並びに培養装置
JP2008526203A (ja) 2004-12-29 2008-07-24 バイオジェン・アイデック・エムエイ・インコーポレイテッド バイオリアクタープロセス制御システムおよび方法

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Publication number Priority date Publication date Assignee Title
JPH0644863B2 (ja) * 1987-01-29 1994-06-15 理化学研究所 細胞の高密度連続培養の立ち上げ方法
JPH07184634A (ja) * 1993-12-28 1995-07-25 Ajinomoto Co Inc 微生物好気培養における培養方法及び装置
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
WO2008118500A1 (en) * 2007-03-27 2008-10-02 Wafergen, Inc. Nutrient perfusion plate with heater & gas exchange for high content screening
BR112012000242B1 (pt) * 2009-07-06 2019-07-09 Genentech Inc Métodos para cultivo em batelada de células eucariontes
US8580554B2 (en) * 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
US20150247210A1 (en) * 2014-02-28 2015-09-03 Asl Analytical, Inc. Methods for Continuous Monitoring and Control of Bioprocesses
BR112016025013B1 (pt) * 2014-04-28 2022-09-20 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V Processo para cultivo de célula regulado por densidade celular para a produção de células eucarióticas e/ou um produto derivado de célula eucariótica, método para a preparação de extrato livre de célula para uma tradução in vitro, método para geração de uma linhagem celular estável, e método para geração de material de células vegetais na forma de um pacote de células multicamada não tecidual, estruturado e poroso privado de meio e para manutenção subsequente do referido pacote de células

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003235544A (ja) 2002-02-20 2003-08-26 Hitachi Ltd 生体細胞の培養制御方法及び培養装置の制御装置並びに培養装置
JP2008526203A (ja) 2004-12-29 2008-07-24 バイオジェン・アイデック・エムエイ・インコーポレイテッド バイオリアクタープロセス制御システムおよび方法

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Publication number Publication date
HRP20210163T1 (hr) 2021-03-19
EP3559203B1 (en) 2020-12-02
JP2020504601A (ja) 2020-02-13
CN110023482A (zh) 2019-07-16
US20200063086A1 (en) 2020-02-27
ES2848701T3 (es) 2021-08-11
JP2022177117A (ja) 2022-11-30
EP3559203A1 (en) 2019-10-30
CN110023482B (zh) 2023-05-02
PL3559203T3 (pl) 2021-05-31
WO2018115161A1 (en) 2018-06-28
SI3559203T1 (sl) 2021-03-31

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