JP7406511B2 - テルペン化合物の生体触媒的な製造方法 - Google Patents

テルペン化合物の生体触媒的な製造方法 Download PDF

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JP7406511B2
JP7406511B2 JP2020567944A JP2020567944A JP7406511B2 JP 7406511 B2 JP7406511 B2 JP 7406511B2 JP 2020567944 A JP2020567944 A JP 2020567944A JP 2020567944 A JP2020567944 A JP 2020567944A JP 7406511 B2 JP7406511 B2 JP 7406511B2
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seq
amino acid
acid sequence
diphosphate
sequence according
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JP2021524261A (ja
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シャルク ミヒェル
ロッチ レティツィア
ソリス エスカランテ ダニエル
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Firmenich SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/07—Diphosphoric monoester hydrolases (3.1.7)
    • C12Y301/07003—Monoterpenyl-diphosphatase (3.1.7.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2020567944A 2018-07-10 2019-07-10 テルペン化合物の生体触媒的な製造方法 Active JP7406511B2 (ja)

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JP2023212519A JP7717142B2 (ja) 2018-07-10 2023-12-15 テルペン化合物の生体触媒的な製造方法

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EP18182783 2018-07-10
EP18182783.3 2018-07-10
PCT/EP2019/068609 WO2020011883A1 (en) 2018-07-10 2019-07-10 Method for biocatalytic production of terpene compounds

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JP2021524261A JP2021524261A (ja) 2021-09-13
JP7406511B2 true JP7406511B2 (ja) 2023-12-27

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US (1) US11214775B2 (enExample)
EP (1) EP3821023A1 (enExample)
JP (2) JP7406511B2 (enExample)
CN (1) CN112334581B (enExample)
BR (1) BR112020024197A2 (enExample)
MX (1) MX2020012933A (enExample)
WO (1) WO2020011883A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024029002A (ja) * 2018-07-10 2024-03-05 フイルメニツヒ ソシエテ アノニム テルペン化合物の生体触媒的な製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12378579B2 (en) 2020-03-06 2025-08-05 Board Of Trustees Of Michigan State University Method to produce the anti-microbial diterpenoid leubethanol and related serrulatane-type diterpenes
US20240327875A1 (en) * 2021-07-16 2024-10-03 Amyris, Inc. Novel enzymes for the production of e-copalol
WO2024256472A2 (en) 2023-06-12 2024-12-19 Firmenich Sa Preparation of terpenoid compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500307A (ja) 1998-03-12 2004-01-08 ウイスコンシン　アラムナイ　リサーチ　フオンデーシヨン 癌治療のためのモノテルペノイド誘導体
WO2017001641A1 (en) 2015-06-30 2017-01-05 Firmenich S.A. Production of manool
CN107119001A (zh) 2017-04-26 2017-09-01 福建师范大学 基因工程化类球红细菌及其制备方法和法尼醇的生产方法

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
CN104031945B (zh) 2008-01-29 2017-08-11 弗门尼舍有限公司 生产香紫苏醇的方法
KR102636404B1 (ko) * 2016-06-15 2024-02-13 경상국립대학교산학협력단 터펜 알코올 또는 그 유도체의 제조 방법
BR112020024197A2 (pt) 2018-07-10 2021-02-17 Firmenich S/A método para produção biocatalítica de compostos de terpeno

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500307A (ja) 1998-03-12 2004-01-08 ウイスコンシン　アラムナイ　リサーチ　フオンデーシヨン 癌治療のためのモノテルペノイド誘導体
WO2017001641A1 (en) 2015-06-30 2017-01-05 Firmenich S.A. Production of manool
CN107119001A (zh) 2017-04-26 2017-09-01 福建师范大学 基因工程化类球红细菌及其制备方法和法尼醇的生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biotechnology Journal，2016年，Vol. 11，pp. 1291-1297，DOI: 10.1002/biot.201600250
ChemBioChem，2017年，Vol. 18, No. 21，pp. 2104-2109，DOI: 10.1002/cbic.201700445

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024029002A (ja) * 2018-07-10 2024-03-05 フイルメニツヒ ソシエテ アノニム テルペン化合物の生体触媒的な製造方法
JP7717142B2 (ja) 2018-07-10 2025-08-01 フイルメニツヒ ソシエテ アノニム テルペン化合物の生体触媒的な製造方法

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WO2020011883A1 (en) 2020-01-16
CN112334581B (zh) 2024-11-12
JP2021524261A (ja) 2021-09-13
MX2020012933A (es) 2021-02-15
US20210222138A1 (en) 2021-07-22
US11214775B2 (en) 2022-01-04
JP7717142B2 (ja) 2025-08-01
EP3821023A1 (en) 2021-05-19
JP2024029002A (ja) 2024-03-05
BR112020024197A2 (pt) 2021-02-17
CN112334581A (zh) 2021-02-05

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