CN112334581B - 生物催化产生萜烯化合物的方法 - Google Patents

生物催化产生萜烯化合物的方法 Download PDF

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Publication number
CN112334581B
CN112334581B CN201980043113.0A CN201980043113A CN112334581B CN 112334581 B CN112334581 B CN 112334581B CN 201980043113 A CN201980043113 A CN 201980043113A CN 112334581 B CN112334581 B CN 112334581B
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seq
amino acid
acid sequence
terpene
diphosphate
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Chinese (zh)
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CN112334581A (zh
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M·沙尔克
L·洛奇
D·索利斯艾斯卡兰特
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Firmenich SA
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Firmenich SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/07—Diphosphoric monoester hydrolases (3.1.7)
    • C12Y301/07003—Monoterpenyl-diphosphatase (3.1.7.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201980043113.0A 2018-07-10 2019-07-10 生物催化产生萜烯化合物的方法 Active CN112334581B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18182783 2018-07-10
EP18182783.3 2018-07-10
PCT/EP2019/068609 WO2020011883A1 (en) 2018-07-10 2019-07-10 Method for biocatalytic production of terpene compounds

Publications (2)

Publication Number Publication Date
CN112334581A CN112334581A (zh) 2021-02-05
CN112334581B true CN112334581B (zh) 2024-11-12

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CN201980043113.0A Active CN112334581B (zh) 2018-07-10 2019-07-10 生物催化产生萜烯化合物的方法

Country Status (7)

Country Link
US (1) US11214775B2 (enExample)
EP (1) EP3821023A1 (enExample)
JP (2) JP7406511B2 (enExample)
CN (1) CN112334581B (enExample)
BR (1) BR112020024197A2 (enExample)
MX (1) MX2020012933A (enExample)
WO (1) WO2020011883A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020024197A2 (pt) * 2018-07-10 2021-02-17 Firmenich S/A método para produção biocatalítica de compostos de terpeno
US12378579B2 (en) 2020-03-06 2025-08-05 Board Of Trustees Of Michigan State University Method to produce the anti-microbial diterpenoid leubethanol and related serrulatane-type diterpenes
US20240327875A1 (en) * 2021-07-16 2024-10-03 Amyris, Inc. Novel enzymes for the production of e-copalol
WO2024256472A2 (en) 2023-06-12 2024-12-19 Firmenich Sa Preparation of terpenoid compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303654B1 (en) * 1998-03-12 2001-10-16 Wisconsin Alumni Research Foundation Acyclic monoterpenoid derivatives
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
CN104031945B (zh) 2008-01-29 2017-08-11 弗门尼舍有限公司 生产香紫苏醇的方法
GB201601249D0 (en) * 2016-01-22 2016-03-09 Firmenich & Cie Production of manool
KR102636404B1 (ko) * 2016-06-15 2024-02-13 경상국립대학교산학협력단 터펜 알코올 또는 그 유도체의 제조 방법
CN107119001B (zh) * 2017-04-26 2019-07-19 福建师范大学 基因工程化类球红细菌及其制备方法和法尼醇的生产方法
BR112020024197A2 (pt) 2018-07-10 2021-02-17 Firmenich S/A método para produção biocatalítica de compostos de terpeno

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Farnesol production in Escherichia coli through the construction of a farnesol biosynthesis pathway - application of PgpB and YbjG phosphatases";Chonglong Wang;《Biotechnology Journal》;第1-22页 *
"Identification of Chimeric αβγ Diterpene Synthases Possessing both TypeII Terpene Cyclase and Prenyltransferase Activities";Takaaki Mitsuhashi;《ChemBioChem》;第1-8页 *

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Publication number Publication date
WO2020011883A1 (en) 2020-01-16
JP2021524261A (ja) 2021-09-13
MX2020012933A (es) 2021-02-15
US20210222138A1 (en) 2021-07-22
US11214775B2 (en) 2022-01-04
JP7406511B2 (ja) 2023-12-27
JP7717142B2 (ja) 2025-08-01
EP3821023A1 (en) 2021-05-19
JP2024029002A (ja) 2024-03-05
BR112020024197A2 (pt) 2021-02-17
CN112334581A (zh) 2021-02-05

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