JP7403476B2 - 誘導唾液生成のための経口錠剤 - Google Patents
誘導唾液生成のための経口錠剤 Download PDFInfo
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- JP7403476B2 JP7403476B2 JP2020564425A JP2020564425A JP7403476B2 JP 7403476 B2 JP7403476 B2 JP 7403476B2 JP 2020564425 A JP2020564425 A JP 2020564425A JP 2020564425 A JP2020564425 A JP 2020564425A JP 7403476 B2 JP7403476 B2 JP 7403476B2
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- 229940041597 tofranil Drugs 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 229960003688 tropisetron Drugs 0.000 description 1
- UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 description 1
- 229960003232 troxerutin Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- 150000003681 vanadium Chemical class 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- 229960000881 verapamil hydrochloride Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 229940009065 wellbutrin Drugs 0.000 description 1
- 239000008256 whipped cream Substances 0.000 description 1
- 235000019222 white chocolate Nutrition 0.000 description 1
- 235000019220 whole milk chocolate Nutrition 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940020965 zoloft Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Description
ナフィシリン、オキサシリン、バンコマイシン、クリンダマイシン、エリスロマイシン、トリメトプリム-スルファメトキサゾール、リファンピン、シプロフロキサシン、広域ペニシリン、アモキシシリン、ゲンタマイシン、セフトリアゾキソン、セフォタキシム、クロラムフェニコール、クラブナート、スルバクタム、プロベネシド、ドキシサイクリン、スペクチノマイシン、セフィキシム、ペニシリンG、ミノシクリン、ベータ-ラクタマーゼ阻害薬;メジオシリン、ピペラシリン、アズトレオナム、ノルフロキサシン、トリメトプリム、セフタジジム、ダプソン。ハロゲン化ジフェニルエーテル類、例えば、2',4,4'-トリクロロ-2-ヒドロキシジフェニルエーテル(Triclosan)、2,2'-ジヒドロキシ-5,5'-ジブロモ-ジフェニルエーテル。ハロゲン化サリチルアニリド類、例えば、4',5-ジブロモサリチルアニリド、3,4',5-トリクロロ-サリチルアニリド、3,4',5-トリブロモ-サリチルアニリド、2,3,3',5-テトラクロロ-サリチルアニリド、3,3,3',5-テトラクロロ-サリチルアニリド、3,5-ジブロモ-3'-トリフルオロメチル-サリチルアニリド、5-n-オクタノイル-3'-トリフルオロメチル-サリチルアニリド、3,5-ジブロモ-4'-トリフルオロメチル-サリチルアニリド、3,5-ジブロモ-3'-トリフルオロメチル-サリチルアニリド(Flurophene)。安息香酸エステル類、例えば、メチル-p-ヒドロキシ安息香酸エステル、エチル-p-ヒドロキシ安息香酸エステル、プロピル-p-ヒドロキシ安息香酸エステル、ブチル-p-ヒドロキシ安息香酸エステル。ハロゲン化カルバニリド類、例えば、3,4,4'-トリクロロカルバニリド、3-トリフルオロメチル-4,4'-ジクロロカルバニリド、又は3,3,4'-トリクロロカルバニリド。フェノール化合物類(フェノール及びその同族体、モノ-及びポリ-アルキル及び芳香族ハロ-フェノール及びそれらの同族体を含む)、例えば、フェノール、2-メチル-フェノール、3-メチル-フェノール、4-メチル-フェノール、4-エチル-フェノール、2,4-ジメチル-フェノール、2,5-ジメチル-フェノール、3,4-ジメチル-フェノール、2,6-ジメチル-フェノール、4-n-プロピル-フェノール、4-n-ブチル-フェノール、4-n-アミル-フェノール、4-tert-アミル-フェノール、4-n-ヘキシル-フェノール、4-n-ヘプチル-フェノール、2-メトキシ-4-(2-プロペニル)-フェノール(オイゲノール)、2-イソプロピル-5-メチル-フェノール(Thymol)、モノ-及びポリ-アルキル-及びアラルキル-ハロフェノール、メチル-p-クロロフェノール、エチル-p-クロロフェノール、n-プロピル-p-クロロフェノール、n-ブチル-p-クロロフェノール、n-アミル-p-クロロフェノール、sec-アミル-p-クロロフェノール、n-ヘキシル-p-クロロフェノール、シクロヘキシル-p-クロロフェノール、n-ヘプチル-p-クロロフェノール、n-オクチル-p-クロロフェノール、o-クロロフェノール、メチル-o-クロロフェノール、エチル-o-クロロフェノール、n-プロピル-o-クロロフェノール、n-ブチル-o-クロロフェノール、n-アミル-o-クロロフェノール、tert-アミル-o-クロロフェノール、n-ヘキシル-o-クロロフェノール、n-ヘプチル-o-クロロフェノール、p-クロロフェノール、o-ベンジル-p-クロロフェノール、o-ベンジル-m-メチル-p-クロロフェノール、o-ベンジル-m,m-ジメチル-p-クロロフェノール、o-フェニルエチル-p-クロロフェノール、o-フェニルエチル-m-メチル-p-クロロフェノール、3-メチル-p-クロロフェノール、3,5-ジメチル-p-クロロフェノール、6-エチル-3-メチル-p-クロロフェノール、6-n-プロピル-3-メチル-p-クロロフェノール、6-iso-プロピル-3-メチル-p-クロロフェノール、2-エチル-3,5-ジメチル-p-クロロフェノール、6-sec-ブチル-3-メチル-p-クロロフェノール、2-iso-プロピル-3,5-ジメチル-p-クロロフェノール、6-ジエチルメチル-3-メチル-p-クロロフェノール、6-iso-プロピル-2-エチル-3-メチル-p-クロロフェノール、2-sec-アミル-3,5-ジメチル-p-クロロフェノール、2-ジエチルメチル-3,5-ジメチル-p-クロロフェノール、6-sec-オクチル-3-メチル-p-クロロフェノール、p-ブロモフェノール、メチル-p-ブロモフェノール、エチル-p-ブロモフェノール、n-プロピル-p-ブロモフェノール、n-ブチル-p-ブロモフェノール、n-アミル-p-ブロモフェノール、sec-アミル-p-ブロモフェノール、n-ヘキシル-p-ブロモフェノール、シクロヘキシル-p-ブロモフェノール、o-ブロモフェノール、tert-アミル-o-ブロモフェノール、n-ヘキシル-o-ブロモフェノール、n-プロピル-m,m-ジメチル-o-ブロモフェノール、2-フェニル-フェノール、4-クロロ-2-メチル-フェノール、4-クロロ-3-メチル-フェノール、4-クロロ-3,5-ジメチル-フェノール、2,4-ジクロロ-3,5-ジメチル-フェノール、3,4,5,6-テトラブロモ-2-メチルフェノール、5-メチル-2-ペンチルフェノール4-イソプロピル-3-メチルフェノール5-クロロ-2-ヒドロキシジフェニル-メタン。レソルシノール及びその誘導体、例えば、レソルシノール、メチル-レソルシノール、エチル-レソルシノール、n-プロピル-レソルシノール、n-ブチル-レソルシノール、n-アミル-レソルシノール、n-ヘキシル-レソルシノール、n-ヘプチル-レソルシノール、n-オクチル-レソルシノール、n-ノニル-レソルシノール、フェニル-レソルシノール、ベンジル-レソルシノール、フェニルエチル-レソルシノール、フェニルプロピル-レソルシノール、p-クロロベンジル-レソルシノール、5-クロロ-2,4-ジヒドロキシジフェニル-メタン、4'-クロロ-2,4-ジヒドロキシジフェニル-メタン、5-ブロモ-2,4-ジヒドロキシジフェニル-メタン、4"-ブロモ-2,4-ジヒドロキシジフェニル-メタン。ビスフェノール化合物類、例えば、ビスフェノールA、2,2'-メチレン-ビス-(4-クロロフェノール)、2,2'-メチレン-ビス-(3,4,6-トリクロロフェノール)(ヘキサクロロフェン)、2,2'-メチレン-ビス-(4-クロロ-6-ブロモフェノール)、ビス-(2-ヒドロキシ-3,5-ジクロロフェニル)-スルフィド、ビス-(2-ヒドロキシ-5-クロロベンジル)-スルフィドである。
i)粒子集団を含み、粒子集団が直接圧縮性(DC)及び非直接圧縮性(非DC)糖アルコール粒子を含む経口錠剤を得る工程と、
ii)錠剤を咀嚼し、それにより、錠剤中の複数の離散した非DC領域により誘導される口腔中唾液を生成させる工程と
を含む方法に関する。
i)粒子集団を含み、粒子集団が直接圧縮性(DC)及び非直接圧縮性(非DC)糖アルコール粒子を含む経口錠剤を得る工程と、
ii)錠剤を咀嚼し、それにより、口内乾燥を緩和又は処置する工程と
を含む方法に関する。
i)粒子集団を含み、粒子集団が直接圧縮性(DC)及び非直接圧縮性(非DC)糖アルコール粒子を含む経口錠剤を得る工程と、
ii)錠剤を咀嚼し、それにより、口腔中で唾液を生成させる工程と、
iii)誘導唾液と共に、1種又は複数の丸剤を嚥下する工程と
を含む方法に関する。
2層錠剤の調製
上のTable 1A(表1)及び1B(表2)並びに2(表3)に示されている組成物をそれぞれ、実施例1~12、13~24及び25~36に概説されているとおりの組成物を有する2層錠剤に加工する。言い換えると、実施例1~12は、Table 1A(表1)及び1B(表2)による第1の層を備え、第2層が主にDCマルチトールをベースとする2層錠剤である。実施例13~24では、第2の層は主にDCキシリトールをベースとする。実施例25~36では、第2の層は主に、Table 2(表3)に示されているとおりのDCイソマルトをベースとする。
HPC:ヒドロキシプロピルセルロース。Ashland社製のKlucel Nutra D
非DCキシリトール:Dupont社製のXivia C
非顆粒化ソルビトール:Cargill社製のPharmSorbidex
非DCイソマルト:Beneo Paltinit社製のIsomalt GS
非DCマンニトール:Roquette社製のPearlitol
非DCマルチトール:Roquette社製のMaltisorb. P200
非DCエリトリトール:Cargill社製のZerose 16952
DCエリトリトール - Cargill社製のZerose 16966
DCキシリトール - Dupont社製のXylitab 200
DCイソマルト - Beneo Paltinit社製のIsomalt DC 101
DCマンニトール - Roquette社製のPearlitol SD200
DCマルチトール - Roquette社製のSweetpearl 300 DC
DCイソマルト - Beneo Paltinit社製のIsomalt DC 101
非DCエリトリトール:Cargill社製のZerose 16952
HPC:ヒドロキシプロピルセルロース。Ashland社製のKlucel Nutra D
DC CaCO3:Scora社製のScoralite 97 PVP
各実施例39~41では、原料を1600ミクロン篩で篩い掛けし、次いで、Table 3B(表5)の例示の組成物に従って適正量に秤量する。
ISX2は、ソルビトール実施例14を指し、
ISX3は、非DCイソマルト実施例15を指し、
ISX4は、非DCエリトリトール実施例16を指し、
ISX5は、非DCマンニトール実施例17を指し、
ISX6は、非DCマルチトール実施例18を指す。
ODT錠剤を含む2層錠剤の調製
種々の濃度の非DC糖アルコールを含む調製
種々の濃度の非DC糖アルコールを含む調製
上のTable 4(表7)、4B(表8)、5(表9)及び6(表10)に示されている組成物をそれぞれ、実施例42~50及び43Bに概説されているとおりの組成物で2層錠剤に加工する。
HPC:ヒドロキシプロピルセルロース。Ashland社製のKlucel Nutra D
非DCキシリトール:Dupont社製のXivia C
非顆粒化ソルビトール:Cargill社製のPharmSorbidex
非DCイソマルト:Beneo Paltinit社製のIsomalt GS
非DCマンニトール:Roquette社製のPearlitol
非DCマルチトール:Roquette社製のMaltisorb. P200
非DCエリトリトール:Cargill社製のZerose 16952
DCエリトリトール - Cargill社製のZerose 16966
DCキシリトール - Dupont社製のXylitab 200
DCイソマルト - Beneo Paltinit社製のIsomalt DC 101
DCマンニトール - Roquette社製のPearlitol SD200
DCマルチトール - Roquette社製のSweetpearl 300 DC
DC CaCO3:Scora社製のScoralite 97 PVP
Pearlitol Flashは、Roquette社の商標である。
微結晶質セルロース(MCC): FMC社製のAvicel PH-105
クロスポビドン:BASF社製のKollidon CL-SF
上の2層実施例42~50及び43Bをウォータリング作用に関して、試験パネルが時間-強度評価構成(time-intensity evaluation set-up)で評価した。ウォータリング作用は、試験パネルにより知覚されるウォータリング作用、すなわち、経口投与及び試験開始の際のウォータリング作用の全体的な印象である。
異なる粒径分布を有する粉末の調製
非DCキシリトール:Dupont社製のXivia C
非DCイソマルト:Beneo Paltinit社製のIsomalt GS
非DCエリトリトール:Cargill社製のZerose 16952
上の粉末実施例51~59が試験パネルにより、経口投与の際に生成した唾液の合計質量に関して評価された。
画分を、再現可能な値が得られるように、中断せずに連続的な手順で試験した。粉末1.0gの画分を容器に秤量した。この試験では、試験者は、試験が開始される前に唾液を嚥下するように指示され、試験中は嚥下を許されなかった。粉末を舌の舌先1/3に置き、頭部を正面に保持し、試験中は嚥下を許されなかった。試験者は、1分当たり約60回の頻度で粉末を咀嚼した。60秒後に、生成した唾液を収集し、唾液の質量を記録した。新たな試験を行う前に、口腔を水ですすぎ、次の試験の前に4分の時間間隔を守った。一連の2回の試験が試験者で行われた。
第1に、これらの結果は明らかに、唾液生成について、非DCエリトリトール(実施例59)が、非DCキシリトール(実施例56)と比較して、非DCイソマルト(実施例53)よりも更に良好な最良の結果をもたらしたことを示す。非DCエリトリトールは試験期間中の唾液の合計生成量については最良の結果を示したが、キシリトール及びイソマルトの結果は両方とも、非常に有利なレベルであったことが特記される。
第2に、これらの結果はまた非常に有利なことに、3種の非DC糖アルコールのすべてについて、500ミクロン超の粒径が、500ミクロン未満と比較して、唾液生成について特に有利であることを示す。500ミクロン超の粒径分布を有する非DCエリトリトール(実施例58)で最良の結果が得られ、キシリトールはより低い値(実施例55)であり、イソマルトが最も低かったが(実施例52)、まだ非常に有利な値であった。
種々の糖アルコールを有する粉末の調製
非DCキシリトール:Dupont社製のXivia C
非DCイソマルト:Beneo Paltinit社製のIsomalt GS
非DCエリトリトール:Cargill社製のZerose 16952
上の粉末実施例60~62が試験パネルにより、経口投与の際に生成する唾液の合計質量に関して評価された。
粉末1.0gの画分を容器に秤量した。この試験では、8人の試験者は、試験が開始される前に唾液を嚥下するように指示された。粉末を舌の舌先1/3に置き、頭部を正面に保持し、試験中は嚥下を許されなかった。試験者は、1分当たり約60回の頻度で粉末を咀嚼した。60秒後に、生成した唾液を収集し、唾液の質量を記録した。新たな試験を行う前に、口腔を水ですすぎ、次の試験の前に4分の時間間隔を守った。一連の2回の試験が試験者で行われた。したがって、合計16の試験サンプルが各原料粉末について生じた。各試験者に、6つのサンプルを試験シリーズで試験させた。各試験シリーズ間に少なくとも30分の間隔が求められた。
非DCイソマルト:Beneo Paltinit社製のIsomalt GS
非DCエリトリトール:Cargill社製のZerose 16952
上の粉末実施例63~66が試験パネルにより、経口投与の際に生成した唾液の合計質量に関して評価された。
粉末1.0gの画分を容器に秤量した。この試験では、8人の試験者は、試験が開始される前に唾液を嚥下するように指示された。粉末を舌の舌先1/3に置き、頭部を正面に保持し、試験中は嚥下を許されなかった。試験者は、1分当たり約60回の頻度で粉末を咀嚼した。60秒後に、生成した唾液を収集し、唾液の質量を記録した。新たな試験を行う前に、口腔を水ですすぎ、次の試験の前に4分の時間間隔を守った。一連の2回の試験が試験者で行われた。したがって、合計16の試験サンプルが各原料粉末について生じた。各試験者に、6つのサンプルを試験シリーズで試験させた。各試験シリーズ間に少なくとも30分の間隔が求められた。
第1に、これらの結果は非常に有利なことに、2種の非DC糖アルコールについて、500ミクロン超の粒径が、500ミクロン未満と比較して特に有利であることを示す。500ミクロン超の粒径分布を有する非DCエリトリトール(実施例66)で最良の結果が得られ、イソマルトが最も低かったが(実施例64)、まだ許容可能な値であった。
第2に、結果は、唾液の生成が非DCイソマルトと比較して非DCエリトリトールで最高であったことを示した。
CaCO3を含む2層錠剤の調製
歯みがき剤を含む2層錠剤の調製
クリーンラベル/天然成分を含む2層錠剤の調製
20 経口錠剤
21 上部モジュール
22 下部モジュール
30 経口錠剤
31 上部モジュール
32 下部モジュール
33 中間モジュール
40 部分、最終経口錠剤
41 非DC糖アルコール粒子、非DC粒子
42 DC粒子
51 非DC粒子
52 DC粒子
60 錠剤
61 非DC糖アルコール粒子
62 DC粒子、DC糖アルコール粒子
63 DC粒子、DC糖アルコール粒子
Claims (18)
- 粒子集団を含む咀嚼用経口錠剤であって、前記粒子集団が、i)ソルビトール、エリトリトール、キシリトール、ラクチトール、マルチトール、マンニトール、イソマルト、及びそれらの組合せの直接圧縮性(DC)粒子からなる群から選択される直接圧縮性(DC)糖アルコール粒子、ならびにii)エリトリトール、マルチトール、キシリトール、イソマルト、ラクチトール、マンニトール、及びそれらの組合せの非直接圧縮性(非DC)粒子からなる群から選択される非直接圧縮性(非DC)糖アルコール粒子を含み、前記経口錠剤中の複数の離散した非DC領域が、非DC粒子を含み、前記非DC領域は、DC糖アルコール粒子の間に分布しており、前記非DC領域が、前記経口錠剤の咀嚼の際に誘導唾液生成をもたらし、前記粒子集団が前記経口錠剤の第1のモジュールに錠剤化されており、前記経口錠剤の第2のモジュール中に錠剤化されている第2の粒子集団と組み合わされており、前記経口錠剤の前記第2のモジュールが非DC糖アルコール粒子を含まない、経口錠剤。
- 前記経口錠剤の前記第2のモジュールが組成において前記経口錠剤の前記第1のモジュールとは異なる、請求項1に記載の経口錠剤。
- 前記経口錠剤の前記第2のモジュールが、前記経口錠剤の経口崩壊モジュールである、請求項1又は2に記載の経口錠剤。
- 前記非DC領域が前記経口錠剤の第1のモジュールに均等に分布している、請求項1から3のいずれか一項に記載の経口錠剤。
- 前記非DC糖アルコール粒子の少なくとも20質量%が500μm超の粒径を有する、請求項1から4のいずれか一項に記載の経口錠剤。
- 前記非DC糖アルコール粒子が、エリトリトール、マルチトール、キシリトール、イソマルト、マンニトール、及びそれらの組合せの非DC粒子からなる群から選択される、請求項1から5のいずれか一項に記載の経口錠剤。
- 前記非DC糖アルコール粒子が、エリトリトール、マルチトール、キシリトール、イソマルト、及びそれらの組合せの非DC粒子からなる群から選択される、請求項1から6のいずれか一項に記載の経口錠剤。
- 前記第2の粒子集団が、ソルビトール、エリトリトール、キシリトール、ラクチトール、マルチトール、マンニトール、イソマルト、及びそれらの組合せのDC粒子からなる群から選択されるDC糖アルコール粒子を含む、請求項1から7のいずれか一項に記載の経口錠剤。
- 前記非DC糖アルコール粒子を前記経口錠剤の少なくとも10質量%の量、例えば前記経口錠剤の少なくとも20質量%の量、例えば前記経口錠剤の少なくとも30質量%の量で含む、請求項1から8のいずれか一項に記載の経口錠剤。
- 前記DC糖アルコール粒子を前記経口錠剤の少なくとも10質量%の量、例えば前記経口錠剤の少なくとも20質量%の量、例えば前記経口錠剤の少なくとも30質量%の量で含む、請求項1から9のいずれか一項に記載の経口錠剤。
- 前記DC糖アルコール粒子の部分を形成している結合剤以外の1種又は複数の結合剤を、前記経口錠剤の0.1~6質量%の量で含む、請求項1から10のいずれか一項に記載の経口錠剤。
- 0.2から1.2の間、例えば0.3から0.7の間の前記非DC糖アルコール粒子と前記DC糖アルコール粒子との間の質量比を有する、請求項1から11のいずれか一項に記載の経口錠剤。
- 少なくとも1種の粘度調整剤を更に含む、請求項1から12のいずれか一項に記載の経口錠剤。
- 活性成分、例えば医薬品活性成分を含む、請求項1から13のいずれか一項に記載の経口錠剤。
- 磨歯剤及び/又は歯みがき剤を前記経口錠剤の少なくとも0.1質量%の量で含む、請求項1から14のいずれか一項に記載の経口錠剤。
- 請求項1から15のいずれか一項に記載の経口錠剤を含む医療用具であって、前記医療用具が口内乾燥の緩和又は処置で使用するためのものである、医療用具。
- 請求項1から15のいずれか一項に記載の経口錠剤を含む医療用具であって、前記医療用具が嚥下障害の緩和又は処置で使用するためのものである、医療用具。
- 医薬品活性成分を口腔中に送達するための方法で使用するための、請求項1から15のいずれか一項に記載の経口錠剤を含む組成物あって、前記方法が、
i)ガム基剤を含む粒子をさらに含む、請求項1から15のいずれか一項に記載の経口錠剤を得る工程と、
ii)前記経口錠剤を咀嚼し、それにより、前記経口錠剤の複数の離散した非DC領域により誘導される口腔中唾液を生成させる工程と、
iii)咀嚼により、前記経口錠剤から水不溶性構成成分を含有する凝集性残留物を得る工程と
を含む、組成物。
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PCT/DK2019/050152 WO2019219142A1 (en) | 2018-05-17 | 2019-05-15 | An oral tablet for induced saliva generation |
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US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
JP6840849B2 (ja) | 2016-11-18 | 2021-03-10 | フェルティン ファルマ アー/エス | 別個の結合剤及びエリスリトールを含む錠剤 |
US11058641B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
US20190350858A1 (en) | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
RU2770035C1 (ru) | 2018-05-17 | 2022-04-14 | Фертин Фарма А/С | Таблетированная жевательная резинка, подходящая для активных фармацевтических ингредиентов |
US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
US11135157B2 (en) | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
US11096895B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
CN113710235B (zh) | 2019-04-17 | 2024-03-29 | 诺狄更斯公司 | 经口大麻素片剂 |
-
2018
- 2018-05-17 US US15/982,758 patent/US11096894B2/en active Active
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2019
- 2019-05-15 PL PL19729175.0T patent/PL3773511T3/pl unknown
- 2019-05-15 CN CN201980032458.6A patent/CN112118834B/zh active Active
- 2019-05-15 DK DK19729175.0T patent/DK3773511T3/da active
- 2019-05-15 ES ES19729175T patent/ES2926159T3/es active Active
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Also Published As
Publication number | Publication date |
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AU2019269879B2 (en) | 2022-07-21 |
DK3773511T3 (da) | 2022-08-22 |
CN112118834B (zh) | 2024-01-02 |
WO2019219142A1 (en) | 2019-11-21 |
EP3773511A1 (en) | 2021-02-17 |
KR20210010856A (ko) | 2021-01-28 |
MX2020012280A (es) | 2022-11-17 |
US20190350859A1 (en) | 2019-11-21 |
ES2926159T3 (es) | 2022-10-24 |
BR112020023173A2 (pt) | 2021-02-09 |
CN112118834A (zh) | 2020-12-22 |
EP3773511B1 (en) | 2022-07-06 |
PL3773511T3 (pl) | 2022-10-10 |
CA3097055A1 (en) | 2019-11-21 |
EP4088716A1 (en) | 2022-11-16 |
US11096894B2 (en) | 2021-08-24 |
CA3097055C (en) | 2022-08-02 |
JP2021524438A (ja) | 2021-09-13 |
AU2019269879A1 (en) | 2020-10-22 |
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