JP7401166B2 - 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 - Google Patents
抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 Download PDFInfo
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- JP7401166B2 JP7401166B2 JP2021529521A JP2021529521A JP7401166B2 JP 7401166 B2 JP7401166 B2 JP 7401166B2 JP 2021529521 A JP2021529521 A JP 2021529521A JP 2021529521 A JP2021529521 A JP 2021529521A JP 7401166 B2 JP7401166 B2 JP 7401166B2
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- antibody
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- btn3a
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A61K2239/50—Colon
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/58—Prostate
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023204480A JP7825605B2 (ja) | 2018-08-01 | 2023-12-04 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
| JP2025160594A JP2026016397A (ja) | 2018-08-01 | 2025-09-26 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306050 | 2018-08-01 | ||
| EP18306050.8 | 2018-08-01 | ||
| EP19153992 | 2019-01-28 | ||
| EP19153992.3 | 2019-01-28 | ||
| PCT/EP2019/070693 WO2020025703A1 (en) | 2018-08-01 | 2019-07-31 | Anti-btn3a antibodies and their use in treating cancer or infectious disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204480A Division JP7825605B2 (ja) | 2018-08-01 | 2023-12-04 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021533204A JP2021533204A (ja) | 2021-12-02 |
| JP2021533204A5 JP2021533204A5 (https=) | 2022-08-05 |
| JPWO2020025703A5 JPWO2020025703A5 (https=) | 2022-08-05 |
| JP7401166B2 true JP7401166B2 (ja) | 2023-12-19 |
Family
ID=67470408
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021529521A Active JP7401166B2 (ja) | 2018-08-01 | 2019-07-31 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
| JP2023204480A Active JP7825605B2 (ja) | 2018-08-01 | 2023-12-04 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
| JP2025160594A Pending JP2026016397A (ja) | 2018-08-01 | 2025-09-26 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204480A Active JP7825605B2 (ja) | 2018-08-01 | 2023-12-04 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
| JP2025160594A Pending JP2026016397A (ja) | 2018-08-01 | 2025-09-26 | 抗btn3a抗体及びがん又は感染性障害の処置におけるその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11987631B2 (https=) |
| EP (2) | EP4650007A3 (https=) |
| JP (3) | JP7401166B2 (https=) |
| KR (1) | KR102949202B1 (https=) |
| CN (2) | CN118459590A (https=) |
| AU (2) | AU2019312831B2 (https=) |
| BR (1) | BR112021001776A2 (https=) |
| CA (2) | CA3275403A1 (https=) |
| CL (1) | CL2021000258A1 (https=) |
| DK (1) | DK3830119T3 (https=) |
| ES (1) | ES3060430T3 (https=) |
| FI (1) | FI3830119T3 (https=) |
| HR (1) | HRP20260034T1 (https=) |
| IL (1) | IL280563B2 (https=) |
| LT (1) | LT3830119T (https=) |
| MX (1) | MX2021001268A (https=) |
| RS (1) | RS67711B1 (https=) |
| SG (1) | SG11202101038SA (https=) |
| SI (1) | SI3830119T1 (https=) |
| SM (1) | SMT202600072T1 (https=) |
| WO (1) | WO2020025703A1 (https=) |
| ZA (1) | ZA202100819B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230183346A1 (en) * | 2016-02-26 | 2023-06-15 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antibodies having specificity for btla and uses thereof |
| HRP20260034T1 (hr) * | 2018-08-01 | 2026-02-27 | Imcheck Therapeutics | Anti-btn3a antitijela i njihova upotreba u liječenju raka ili infektivnih poremećaja |
| AU2022293581A1 (en) * | 2021-06-18 | 2024-01-25 | Therini Bio, Inc. | ANTIBODIES WHICH BIND HUMAN FIBRIN OR FIBRINOGEN γC DOMAIN AND METHODS OF USE |
| TW202313695A (zh) | 2021-09-15 | 2023-04-01 | 法商感應檢查療法公司 | 抗btn3a抗體在製備用於治療腫瘤的藥物的用途 |
| WO2023052541A1 (en) | 2021-09-30 | 2023-04-06 | Imcheck Therapeutics | Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy |
| JP2024539893A (ja) | 2021-10-27 | 2024-10-31 | イムチェック セラピューティクス エスエーエス | 感染性障害を治療する方法で使用するためのブチロフィリン(btn)3a活性化抗体 |
| KR20240149438A (ko) | 2022-02-27 | 2024-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | Cd277 및 종양-항원에 대한 이중특이적 항체 |
| WO2024074498A1 (en) | 2022-10-04 | 2024-04-11 | Imcheck Therapeutics | Combination of a btn3a activating antibody, a bcl2 inhibitor and hypomethylating agent for use in treating cancer |
| JP2026506893A (ja) | 2023-02-23 | 2026-02-27 | イムチェック セラピューティクス エスエーエス | Btn3a活性化抗体と免役チェックポイント阻害剤の併用 |
| TW202506731A (zh) | 2023-04-27 | 2025-02-16 | 法商感應檢查療法公司 | 治療多重抗藥性細菌感染之方法 |
| WO2024261239A1 (en) | 2023-06-23 | 2024-12-26 | Imcheck Therapeutics | Bispecific antibodies targeting btn3a and the pd-1/pd-l1 inhibitory axis |
| WO2025031287A1 (zh) * | 2023-08-04 | 2025-02-13 | 江苏恒瑞医药股份有限公司 | Btn3a结合蛋白及其医药用途 |
| WO2025223116A1 (en) * | 2024-04-24 | 2025-10-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-btn3a antibodies and uses thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503852A (ja) | 2009-09-06 | 2013-02-04 | プロトエービー リミテッド | Hsp65由来のペプチド6に特異的なヒト化抗体、その方法及び使用 |
| JP2013535190A (ja) | 2010-07-15 | 2013-09-12 | シノベックス コーポレーション | カドヘリン−11のec1ドメインを標的とするヒト化抗体ならびに関連組成物および方法 |
| JP2014503522A (ja) | 2010-12-15 | 2014-02-13 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 抗cd277抗体およびその使用 |
| US20150353643A1 (en) | 2013-09-24 | 2015-12-10 | Universite De La Mediterranee - Aix-Marseille Ii | Anti-cd277 antibodies and uses thereof |
| JP2017521097A (ja) | 2014-06-27 | 2017-08-03 | シー・2・エヌ・ダイアグノスティクス・エル・エル・シー | ヒト化抗タウ抗体 |
Family Cites Families (22)
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