JP7378167B2 - 8‐シクロペンチル‐7‐オキソ‐2‐(4‐ピペラジン‐1‐イル‐フェニルアミノ)‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐6‐カルボニトリル及び同化合物の増殖性障害の治療における使用 - Google Patents
8‐シクロペンチル‐7‐オキソ‐2‐(4‐ピペラジン‐1‐イル‐フェニルアミノ)‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐6‐カルボニトリル及び同化合物の増殖性障害の治療における使用 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Description
別段の定義のない限り、本明細書中で使用される技術用語及び科学用語は全て、本発明が属する分野の当業者が一般に理解しているのと同じ意味を有する。
本発明の化合物は、塩の形態をとることができる。「塩」という用語は、本発明の化合物である式Iの化合物の付加塩を包含する。「薬学的に許容可能な塩」という用語は、医薬としての適用において有用性をもたらす範囲内の毒性プロファイルを有する塩を指す。とはいえ薬学的に許容不可能な塩が、本発明の実行における有用性、例えば本発明の化合物の合成、精製又は製剤化の処理過程における有用性を備えた特性、例えば高結晶度を有する場合もある。
下記の実施例1は、式Iの化合物及びその塩の合成のための方法を提供する。本発明の塩及び中間体を含む化合物はその反応混合物から分離され、標準的な技法、例えば濾過、液液抽出、固相抽出、蒸留、再結晶、又はフラッシュカラムクロマトグラフィ若しくはHPLCを含むクロマトグラフィによって、精製されることが可能である。式Iの化合物又はその塩の精製のための好ましい方法は、好ましくは結晶形態の化合物又はその塩を形成するために、溶媒から該化合物又は塩を結晶化させることを含む。結晶化に続いて、結晶化溶媒を蒸発以外の処理手順、例えば濾過又は傾瀉によって取り除き、次いで好ましくは結晶を純粋な溶媒(又は純粋な溶媒の混合物)を使用して洗浄する。結晶化のための好ましい溶媒には、水、アルコール、特に4個以下の炭素原子を含有するアルコールであって例えばメタノール、エタノール、イソプロパノール、及びブタン‐1‐オール、ブタン‐2‐オール、及び2‐メチル‐2‐プロパノールなど、エーテル、例えばジエチルエーテル、ジイソプロピルエーテル、t‐ブチルメチルエーテル、1,2‐ジメトキシエタン、テトラヒドロフラン及び1,4‐ジオキサン、カルボン酸、例えばギ酸及び酢酸、並びに炭化水素系溶媒、例えばペンタン、ヘキサン、トルエン、並びにこれらの混合物、特に水性エタノールのような水性混合物が挙げられる。その他の可能な溶媒には酢酸エチルが挙げられる。純粋な溶媒であって好ましくは少なくとも分析等級のもの、より好ましくは製薬等級のものが使用されることが好ましい。本発明の処理手順の好ましい実施形態では、生成物はそのようにして分離される。式Iの本発明の化合物又はその塩、及びこれらの医薬組成物において、式Iの化合物又はその塩は好ましくは結晶形態であるか又は結晶形態から調製され、好ましくはそのような処理手順によって調製されたものである。
8‐シクロペンチル‐7‐オキソ‐2‐(4‐ピペラジン‐1‐イル‐フェニルアミノ)‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐6‐カルボニトリル及びその薬学的に許容可能な塩は、多種多様な投薬剤形で投与可能である。本発明の化合物は、薬学的に許容可能な担体と組み合わせて、医薬組成物の形態で投与されてもよい。そのような製剤中の有効成分は、0.1~99.99重量パーセントを構成することができる。「薬学的に許容可能な担体」とは、製剤の他の成分と共存可能であり、かつ被投与者に対して有害でない任意の担体、希釈剤又は添加剤を意味する。
本発明の別の実施形態によれば、細胞増殖性障害、特にがんに罹患している個体を治療する方法であって、有効な量の式Iの少なくとも1つ化合物又はその薬学的に許容可能な塩を、単独で、又は薬学的に許容可能な担体と組み合わせて、前記個体に投与することを含む方法が提供される。
副腎のがん、例えば神経芽細胞腫、が挙げられる。
本発明の1つの実施形態によれば、式Iの化合物及びその薬学的に許容可能な塩は、1以上の特定の抗がん剤に対して耐性の腫瘍細胞を有している薬物耐性がんの患者に投与することができる。
式Iの化合物の合成スキームは
4‐(4‐アミノフェニル)‐ピペラジン‐1‐カルボン酸tert‐ブチルエステル(1.2g、3.96mmol)をトルエン(25mL)に溶解して10分間撹拌した。8‐シクロペンチル‐2‐メタンスルフィニル‐7‐オキソ‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐6‐カルボニトリル(1.0g、3.31mmol)を上記の溶液に加え、10mLのトルエンでフラスコを洗い、70~80℃に加熱して4時間維持した。質量分析計でモニタリングが行われた反応の完了後、反応混合物を室温まで冷却して一晩放置した。形成された固体を濾別し、トルエン(20mL)で洗浄し、真空下で乾燥させた。収量は1.56g(91%)であった。
Mass: m/z 516.10
4‐[4‐(6‐シアノ‐8‐シクロペンチル‐7‐オキソ‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐2‐イル‐アミノ)‐フェニル]‐ピペラジン‐1‐カルボン酸tert‐ブチルエステル(0.75g、14.5mmol)をジクロロメタン(90mL)に溶解して0℃に冷却した。この冷却された撹拌中の溶液に、30mLのジクロロメタンに溶解した19.41g(170.23mmol)のトリフルオロ酢酸を冷却された溶液に30分間かけてゆっくり加え、0℃に4時間維持した。質量分析計でモニタリングが行われた反応の完了後、溶媒を室温にて真空下で蒸発させ、残留物をジエチルエーテル(100mL)で希釈して0℃で15分間撹拌した。形成された固体を濾別し、ジエチルエーテル(50mL)で洗浄し、真空下で乾燥させてそのまま次のステップで使用した。粗収量は0.85g(定量値)であった。
Mass: m/z 416.10(質量分析は遊離塩基として示している。)
8‐シクロペンチル‐7‐オキソ‐2‐(4‐ピペラジン‐1‐イル‐フェニルアミノ)‐7,8‐ジヒドロ‐ピリド[2,3‐d]ピリミジン‐6‐カルボニトリルトリフルオロ酢酸(0.045g)を水(15mL)に溶解して10分間撹拌した。この溶解した溶液を濾過して0℃に冷却した。7%の水酸化ナトリウム溶液(6~7滴)を加えて溶液のpHを7.0~7.5に調整し、該溶液を0℃に1時間維持した。形成された固体を濾別し、水(5mL)で洗浄し、真空下で乾燥させて一晩放置した。収量は0.020g(57.1%)であった。
Mass: m/z 416.10
パルボシクリブは以下の構造
化合物を、4種のがん細胞株すなわちDU145(ヒト前立腺がん)、GRANTA‐519(ヒトB細胞リンパ腫)、HeLa(ヒト子宮頸がん)、及びK‐562(ヒト慢性骨髄性白血病)で試験した。驚いたことに、ON123580は、ヒトB細胞リンパ腫細胞を含む4種の細胞株全てについて強力な細胞毒性薬であった。
ウシ胎児血清(FBS)、(ExCell Bio、カタログ番号FND500。-20℃で保管)。
* 1×100mL CellTiter‐Glo(登録商標)バッファー
* 1×バイアル CellTiter‐Glo(登録商標)基質(凍結乾燥品)
a. CellTiter‐Gloバッファーを解凍して使用前に室温にする。
便宜上、CellTiter‐Gloバッファーを解凍して使用前に最大48時間まで室温で保管してもよい。
b. 凍結乾燥状態のCellTiter‐Glo基質を使用前に室温にする。
c. 適正量(100mL)のCellTiter‐GloバッファーをCellTiter‐Glo基質が入った褐色ボトルに移して、凍結乾燥酵素/基質混合物を再構成する。これでCellTiter‐Glo試薬が作られる。
注:CellTiter‐Gloバッファーのボトルの液体全量をCellTiter‐Glo基質バイアルに加えればよい。
d. 穏やかに渦流混合し、旋回混合することにより、又は内容物を転倒混和することにより混合して、均一な溶液を得る。CellTiter‐Glo基質は1分未満で容易に溶解するはずである。
1. 対数増殖期に細胞を採取してCount‐star(登録商標)を用いて細胞を計数する。
2. それぞれの培地を用いて細胞の濃度を4.44×104個/mLに調整する。
3. 90μLの細胞懸濁液を2枚の96ウェルプレート(プレートA及びB)に加えて最終的な細胞密度を4×103個/ウェルとする。(細胞の濃度はデータベース又は密度最適化アッセイに従って調整する。)
1)T0での読み取り用にプレートAの各ウェルに10μLの培地を添加する。
2)プレート及びその内容物をRTでおよそ30分間平衡化する。
3)50μLのCellTiter‐Glo(CTG)試薬を各ウェルに添加する。
4)内容物をオービタルシェーカーで5分間混合して細胞溶解を誘導する。
5)プレートをRTで20分間インキュベートして発光シグナルを安定させる。
注:温度勾配、細胞播種のムラ又はマルチウェルプレートのエッジ効果により、標準プレート内で不均一な発光シグナルがもたらされる可能性がある。
6)EnVision(登録商標)マルチラベルリーダ(Multi Label Reader)を使用して発光(T0)を記録する。
1)被験物質の10×溶液を調製する(最も高い作業用濃度を培地中100μMの被験物質として3.16倍系列希釈で9用量レベルとする。出発時の薬物濃度はDMSO中に40mMで最終希釈物の薬物濃度は4μMとした)。
2)シスプラチンの10×参照用対照溶液を調製する(最も高い作業用濃度を培地中100μMとして3.16倍系列希釈とした。(出発時のシスプラチン(ホスピーラ・オーストラリア(Hospira Australia)製)の濃度を3.33mMとして)最終希釈物の薬物濃度は細胞培養培地中に100nMとした)。
3)被験物質及び参照用対照いずれについても10μL(10×)薬物溶液をプレートBの各ウェルに(各薬物濃度につき3連で)分注する。(培地中のDMSO終濃度:0.25%[v/v])。
4)この試験用プレートBを37℃で5%CO2の加湿型インキュベータで72時間インキュベートし、次いでCTGアッセイにより計測する。
5)プレート及びその内容物をRTでおよそ30分間平衡化する。
6)50μLのCellTiter‐Glo試薬を各ウェルに添加する。
7)内容物をオービタルシェーカーで5分間混合して細胞溶解を誘導する。
8)プレートをRTで20分間インキュベートして発光シグナルを安定させる。
注:温度勾配、細胞播種のムラ又はマルチウォール(multiwall)プレートのエッジ効果により、標準プレート内で不均一な発光シグナルがもたらされる可能性がある。
9)発光を記録する。
Claims (17)
- 式I
- 式I
- 異常な細胞増殖によってもたらされる状態を治療するための医薬組成物であって、有効量の請求項1に記載の化合物又はその薬学的に許容可能な塩を含み、投与を必要とする対象者に投与される、前記医薬組成物。
- 前記状態はがんであり、前記対象者はヒトである、請求項3に記載の医薬組成物。
- 前記がんは、卵巣がん、子宮頸がん、子宮がん、膣がん、乳がん、前立腺がん、睾丸がん、肺がん、腎臓がん、結腸直腸がん、胃がん、副腎がん、口腔がん、食道がん、肝臓がん、胆嚢がん、骨がん、白血病、リンパ腺がん、眼がん、皮膚がん、及び脳腫瘍から選択される、請求項4に記載の医薬組成物。
- がんは、急性骨髄性白血病、慢性骨髄性白血病、急性リンパ性白血病、及び慢性リンパ性白血病から選択される、請求項5に記載の医薬組成物。
- 前記がんはリンパ腫である、請求項4に記載の医薬組成物。
- 前記リンパ腫はB細胞非ホジキンリンパ腫である、請求項7に記載の医薬組成物。
- 前記リンパ腫はマントル細胞リンパ腫である、請求項8に記載の医薬組成物。
- 前記対象者はヒトであり、細胞増殖性障害は、新生児血管腫症、二次性進行性多発性硬化症、アテローム性動脈硬化、慢性進行性骨髄変性疾患、神経線維腫症、神経節神経腫症、ケロイド形成、骨パジェット病、乳房線維嚢胞病、子宮筋腫、ペイロニー病、デュピュイトラン病、再狭窄症、良性増殖性乳房疾患、良性前立腺過形成、X連鎖リンパ球増殖性障害、移植後リンパ球増殖性障害、黄斑変性症、網膜症、増殖性硝子体網膜症、及び非がん性リンパ球増殖性障害からなる群から選択される、請求項3に記載の医薬組成物。
- 哺乳動物においてキナーゼ活性を阻害するための医薬組成物であって、治療上有効な量の請求項1に記載の化合物、又はその薬学的に許容可能な塩を含み、そのような治療を必要とする患者に投与される、前記医薬組成物。
- 前記患者は、乳がん、多発性骨髄腫、B細胞リンパ腫、前立腺がん、又は子宮頸がんに罹患しているヒトである、請求項11に記載の医薬組成物。
- がんに侵された個体においてがん細胞のアポトーシスを誘導するための医薬組成物であって、有効量の請求項1に記載の化合物、又はその塩を含み、前記個体に投与される、前記医薬組成物。
- 前記個体は、乳がん、多発性骨髄腫、B細胞リンパ腫、前立腺がん、及び子宮頸がんから選択されたがんに侵されたヒトである、請求項13に記載の医薬組成物。
- 前記がんは、乳がん、多発性骨髄腫、B細胞リンパ腫、前立腺がん、及び子宮頸がんから選択される、請求項5に記載の医薬組成物。
- 前記がんは乳がんである、請求項5に記載の医薬組成物。
- がんは、ホルモン受容体陽性であり、ヒト上皮成長因子受容体2陰性の進行性又は転移性の乳がんである、請求項16に記載の医薬組成物。
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JP2024010072A (ja) | 2024-01-23 |
US20220002293A1 (en) | 2022-01-06 |
JP2022520300A (ja) | 2022-03-30 |
EP3880206A1 (en) | 2021-09-22 |
CN112969463A (zh) | 2021-06-15 |
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